Research

G-Quadruplex.

Summary.

Telomeres are a region of repetitive sequences at the end of a cromosomes which protect the end of the cromosome from deterioration.

As DNA replicates, and after a series of divisions, the last part of the cell becomes weaker until eventually, the life of the cell is not viable anymore.

This process does not happen inside the carcinogenic embryonic cells because there is a protein called “telomerase”at the end of the chromosomes, which avoids telomerers from becoming smaller, allowing the reproduction of the cell. By this way, the cell can freely split up indefinitely.

Telomerase is present in the 80-90 per cent of known cancers and other illness such as Falconi’s anaemia, Werner syndrome and chromosome X-fragile syndrome.

After consulting many scientific journals, web pages, and specialists in this field, we have been able to say that the process of telomerase inhibition would be possible at prestigious universities and centres dedicated to scientific research, which posses the necessary resources.

Most inhibitions have been carried out through the acion of G-Quadruplex, that are nucleic acid sequences that are rich in guanine and are capable of forming a four-stranded structure. This quadruple chain which forms DNA is capable of slowing down or even stopping the telomerase from advancing, as if it were a "Knot", acting as an inhibitory structure.

These studies show that G-Quadruplex does not possess great stability in the telomeric DNA strand. For this reason the application of this molecule is not feasible in most of the cases studied. Moreover, the known ligants that have been used to stabilize the molecule have turned out to be toxic for the cell, which further complicates the scientific task at hand of obtaining an effective inhibiton.

G-Quadruplex [Document 1 & Document 2] is not only present in the DNA multiplying process, but also in the transcription, recombination and translation during secondary processes.

[Document 1]