How does O-GlcNAcylation regulate the subcellular localization and 
transcriptional activity of Beta(β)-catenin in Prostate Cancer progression?



To determine specific sites of O-GlcNAcylation of β-catenin.

To determine the effects of O-GlcNAcylation on β-catenin’s function.



To determine the mechanism(s) which regulate the O-GlcNAcylation
of β-catenin.

To assess the universality of β-catenin O-GlcNAcylation.


Terms Defined 

β-catenin is a potent cancer promoting protein of the Wnt signaling pathway that has been implicated in many pediatric and adult cancers.


O-GlcNAcylation is a recently identified and novel post translational modification involving the addition of a single monosaccharide, O-GlcNAc, to serine and threonine residues of nuclear and cytoplasmic proteins.