Question

How does O-GlcNAcylation regulate the subcellular localization and 
transcriptional activity of Beta(β)-catenin in Prostate Cancer progression?

 

AIM 1

To determine specific sites of O-GlcNAcylation of β-catenin.

To determine the effects of O-GlcNAcylation on β-catenin’s function.

 

AIM 2

To determine the mechanism(s) which regulate the O-GlcNAcylation
of β-catenin.

To assess the universality of β-catenin O-GlcNAcylation.
 

 

 
 
 
Terms Defined 
 
 

β-catenin is a potent cancer promoting protein of the Wnt signaling pathway that has been implicated in many pediatric and adult cancers.

 
 
 
 

O-GlcNAcylation is a recently identified and novel post translational modification involving the addition of a single monosaccharide, O-GlcNAc, to serine and threonine residues of nuclear and cytoplasmic proteins.