We are currently working to expand the Ribosomal RNA mutation Database to include mutations in ribosomal proteins and ribosomal factors. The expanded database is entitled The Ribosomal Mutation Database. Please send bibliographic citations for published work to be included in The Ribosomal Mutation Database to the curator via email: firstname.lastname@example.org.
A review of additional mutations in ribosomal RNA, ribosomal proteins and ribosomal factors (Triman, 2007) was published in Advances in Genetics, volume 58, pages 89-119. The ribosomal RNA mutations are organized into lists by molecule and domain. Two lists of ribosomal protein mutations are organized by ribosomal subunit. Factor mutations are listed by ribosomal function: initiation, elongation, release or recycling. We are in the process of providing access to these data from the 2007 review from this searchable database. In the meantime, the 2007 publication should be cited as the most recent reference to the compilation.
Access to the expanded versions of the 16S and 23S Ribosomal RNA Mutation Databases has been improved to permit searches of the lists of alterations for all the data from (1) one specific organism, (2) one specific nucleotide position, (3) one specific phenotype, or (4) a particular author.
The database currently consists of 1024 records, including 485 16S rRNA records from Escherichia coli, 37 16S-like rRNA records from other organisms, 421 23S rRNA records from E. coli, and 81 23S-like records from other organisms. The numbering of positions in all records corresponds to the numbering in E. coli. We welcome any suggested revisions to the database, as well as information about newly characterized 16S or 23S rRNA mutations.
We are grateful to Janan Eppig, Carol Bult, and Debra Krupke from the Bioinformatics Group at the Jackson Laboratory for their expert advice on the use of appropriate database software. This work was supported by the National Science Foundation (MCB-9726951).