The 7th EUROECOTOX newsletter has been published and can be downloaded at http://bit.ly/euroecotox-enl-7. The main feature is a report by Adam Lillicrap (NIVA) and Teresa Norberg-King (US EPA) on the Animal Alternatives Advisory Group (AAAG) meeting, held during the 2014 SETAC Europe annual meeting in Basel, to discuss progress in the state of the science within animal alternatives for environmental toxicity testing.
The sixth EUROECOTOX newsletter has been published and can be downloaded at http://bit.ly/euroecotox-enl06. It covers the future plans for the network, the final activities of the FP7 project consortium, projects on alternative methods in ecotoxicology and announcements of upcoming related events. We hope that you will find this edition useful and informative; your feedback and suggestions are always welcome.
Article explores European perspective on alternatives to animal testing for environmental hazard identification and risk assessment.
Authored by members of the EUROECOTOX Consortium, this article in Regulatory Toxicology and Pharmacology explores European perspective on alternatives to animal testing for environmental hazard identification and risk assessment:
Scholz S, Sela E, Blaha L, Braunbeck T, Galay-Burgos M, García-Franco
M, Guinea J. Klüver N, Schirmer K, Tanneberger K, Tobor-Kaplon M,
Witters H, Belanger S, Benfenati E, Creton S, Cronin MTD, Eggen RIL,
Embry M, Ekman D, Gourmelon A, Halder M, Hardy B, Hartung T, Hubesch B,
Jungmann D, Lampi MA, Lee L, Léonard M, Küster E, Lillicrap A,
Luckenbach T, Murk AJ, Navas JM, Peijnenburg W, Repetto G, Salinas E,
Schüürmann G, Spielmann H, Tollefsen KE, Walter-Rohde S, Whale G,
Wheeler JR, Winter MJ. 2013.
Link to publisher's website: http://bit.ly/ecetoc-art-2013-scholz-et-al
Tests with vertebrates are an integral part of environmental hazard identification and risk assessment of chemicals, plant protection products, pharmaceuticals, biocides, feed additives and effluents. These tests raise ethical and economic concerns and are considered as inappropriate for assessing all of the substances and effluents that require regulatory testing. Hence, there is a strong demand for replacement, reduction and refinement strategies and methods. However, until now alternative approaches have only rarely been used in regulatory settings. This review provides an overview on current regulations of chemicals and the requirements for animal tests in environmental hazard and risk assessment. It aims to highlight the potential areas for alternative approaches in environmental hazard identification and risk assessment. Perspectives and limitations of alternative approaches to animal tests using vertebrates in environmental toxicology, i.e. mainly fish and amphibians, are discussed. Free access to existing (proprietary) animal test data, availability of validated alternative methods and a practical implementation of conceptual approaches such as the Adverse Outcome Pathways and Integrated Testing Strategies were identified as major requirements towards the successful development and implementation of alternative approaches. Although this article focusses on European regulations, its considerations and conclusions are of global relevance.
It includes the latest news of the project activities, announcements, the mapping out future course of EUROECOTOX Network and in focus article about Non-testing approaches and 3Rs in Environmental Risk Assessment (ERA).
Please click here to download it.
The first edition of PiLAS (Perspectives in Laboratory Animal Science) is now available online. The aim of PiLAS is to improve the quality of discussion about animal experimentation and alternative approaches, by offering bio-scientists in all relevant fields an opportunity to share their expertise, knowledge and ideas concerning these and other issues raised by laboratory animal use.
Rresearchers involved in laboratory animal work, the search for alternatives, veterinary science, or any other relevant area, may read, and respond to, the articles in each issue. Contributions would also be welcome.
Your comments can be submitted by using the form on the website, or by contacting email@example.com by email.
Among the articles in the first edition are:
A Risk Assessment Approach to Severity Classification in Animal Research
David B Morton
Animal Use in Veterinary Education - The Need for a Fourth R: Respect
Animals are More than Tools
Coenraad Hendriksen & Vera Baumans & Bas Blaauboer
Automated Homecage Behavioural Analysis and the Implementation of the Three Rs in Research Involving Mice
Claire A Richardson
Experience of the Use of Table-top Simulators as Alternatives in the Primary Surgical Training of Veterinary Undergraduate Students
Juan Jose Perez-Rivero & Emilio Rendon-Franco
Toward a Humanised Alternative to the Use of Laboratory Animals for Blood-Brain Barrier Research
The Concept, Sources and Incidence of Inhumanity and its Diminution or Removal Through Implementation of the Three Rs
Click here to be taken to the site.
The Organisation for Economic Co-operation and Development (OECD) has officially adopted two test guidelines for test methods to identify substances with the potential to affect the function of the endocrine system. Both test guidelines describe in vitro methods that do not use animals, and the tests are appropriate for use in the U.S. Environmental Protection Agency (EPA) Endocrine Disruptor Screening Program.
The new test guidelines are available on the ICCVAM website:
OECD Test Guideline 457: “BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists.
FRAME is to make early issues of its scientific journal free access, as part of its commitment to sharing knowledge and expertise in the field of the Three Rs. Editorials and abstracts of articles in ATLA (Alternatives to Laboratory Animals) have always been available through the FRAME website, free of charge.
Access to the current issue and the immediately previous one, will still be subscription only, but Volume 38 (2010) and before will now be unlocked so they will be accessible without cost.
Readers will still need to register their name and email address to receive a username and password to gain access, but, once logged in, there will be no further restrictions. Volume 38 is already available, and earlier volumes will be released over the coming weeks.
Here are the contents of the current issue, with links to abstracts and free articles.
A Pilot Study on the Refinement of Acute Inhalation Toxicity Studies: The Isolated Perfused Rat Lung as a Screening Tool for Surface-active Substances
Monika Fischer, Wolfgang Koch, Horst Windt and Clemens Dasenbrock
Statistics of Scientific Procedures on Living Animals 2011: Another Increase in Experimentation, but is there a Shift in Emphasis?
BRNO (Czech Republic), 1-2 October 2012
During the 1st. and 2nd. of October, the EUROECOTOX consortium met in Brno (Czech Republic) for the final project meeting, hosted by partners from the Masaryk University. The meeting provided a forum for discussion and work on the final project deliverables and the existing possibilities for the continuation of the EUROECOTOX network, once the FP7 funding finishes next 30th of November.
Successful 1st European Conference on the Replacement, Reduction and Refinement of Animal Experiments in Ecotoxicology
Last 28th-29th June 2012 the “1st European Conference on the Replacement, Reduction and Refinement of Animal Experiments in Ecotoxicology” was successfully carried out in Dübendorf (Switzerland). The conference was organized by Eawag (Swiss Federal Research Institute of Aquatic Science and Technology), one of the partners of EUROECOTOX, a coordinating action funded by the European Community's Seventh Framework Programme.
The conference provided a good platform for young scientists and experts from academia, industry and regulation in the field of 3Rs of animal tests used in environmental risk assessment. It focused on the current state and future directions of the development, implementation and application of the 3Rs, from bench to acceptance. An exciting programme was put in place based on invited key note speakers and presentations from submitted abstracts. A special key note lecture was given by Susanna Louhimies (DG Environment, European Commission) about the establishment of the 3Rs in European Legislation. About 62% of participants were from academia, 22% from industry and 16% from regulators and stakeholders. A short summary of the conference, programme and abstracts is available from EUROECOTOX DOCUMENTS as EUROECOTOX final conference proceedings.pdf.
The event was co-funded by the European Society of Toxicology in Vitro (ESTIV), who sponsored the participation of ESTIV members and gave two prizes for young scientist’s presentation and poster.
EAWAG Picture Copyright
EURL ECVAM launches a tender for a validation study on in vitro methods that identify chemicals with androgenic or anti-androgenic activity
Generation of data using 'in vitro' test systems to support an EURL ECVAM validation project JRC/IPR/2012/I.2/034/OC.
Also available PDF version of the announcement.
Deadline on October 11th, 2012.