Autodigestion by Pancreatic Digestive Enzymes Leads to Death. Blockade of Pancreatic Digestive Enzymes in the Intestine Reduces Mortality in Shock ... Abstract
Acute Insulin Resistance in Shock is due to Cleavage of the Insulin Receptor by Digestive Enzymes. Abstract
Vasopressure Drug Resistance in Shock is due to Adrenergic Receptor Cleavage by Digestive Enzymes. Abstract
The Repulsive Odor in the Breath during Shock is due to Autodigestion Abstract
Mucin as a Barrier for Pancreatic Digestive Enzymes - If this barrier is breached you may be digested by your own pancreatic enzymes... Read more
Patients in Septic Shock degrade proteins and generate numerous peptides. A high abundance of peptides preducts death. Text
Leptin-Resistance and Loss of Satiety
Loss of Satiety and Desire to Eat During High Fat Diet is due to Proteolytic Cleavage of the Leptin Receptor in the Brain. Abstract. An example for proteolytic receptor cleavage in the metabolic syndrome causing co-morbidites. Link
Gastrointestinal Injury in Infants Due to Formula Feeding:
A Mechanism for Asperger’s Spectrum Syndrome?
We uncovered a mechanism in-vitro for potential injury to intestine and other tissues of an infant due to formula feeding Read more
PMID: 23007028, PMID:24840512, PMID: 26230900
Caveolae as Fluid Shear Stress Shelters. Abstract
Investigate and minimize Autodigestion
as Mechanism for human diseases, aging and death.
We develop bioengineering tools to identify cellular and molecular mechanisms that lead to tissue and organ dysfunction by digestive enzymes.
We design new clinical trials to minimize cell dysfunctions and tissue destruction by digestive enzymes.