Center for

Autodigestion Innovation

Recent Discoveries


Autodigestion by Pancreatic Digestive Enzymes Leads to Death. Blockade of Pancreatic Digestive Enzymes in the Intestine Reduces Mortality in Shock ... Abstract

Acute Insulin Resistance in Shock is due to Cleavage of the Insulin Receptor by Digestive Enzymes. Abstract

Vasopressure Drug Resistance in Shock is due to Adrenergic Receptor Cleavage by Digestive Enzymes. Abstract

The Repulsive Odor in the Breath during Shock is due to Autodigestion Abstract

Mucin as a Barrier for Pancreatic Digestive Enzymes - If this barrier is breached you may be digested by your own pancreatic enzymes... Read more

The first time the life of a severely injured septic patient could be saved by deliberate blockade of the digestive ... Read more. Abstract

Patients in Septic Shock degrade proteins and generate numerous peptides. A high abundance of peptides preducts death. Text

Leptin-Resistance and Loss of Satiety

Loss of Satiety and Desire to Eat During High Fat Diet is due to Proteolytic Cleavage of the Leptin Receptor in the Brain. Abstract. An example for proteolytic receptor cleavage in the metabolic syndrome causing co-morbidites. Link

Gastrointestinal Injury in Infants Due to Formula Feeding:

A Mechanism for Asperger’s Spectrum Syndrome?

We uncovered a mechanism in-vitro for potential injury to intestine and other tissues of an infant due to formula feeding Read more

Breast Milk, Digestive Enzymes and Intestinal Symptoms in Infants

PMID: 23007028, PMID:24840512, PMID: 26230900

More News

Caveolae as Fluid Shear Stress Shelters. Abstract

Our Mission

Investigate and minimize Autodigestion

as Mechanism for human diseases, aging and death.

We develop bioengineering tools to identify cellular and molecular mechanisms that lead to tissue and organ dysfunction by digestive enzymes.

We design new clinical trials to minimize cell dysfunctions and tissue destruction by digestive enzymes.

Microcirculation Slides