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Transfusion

Pre & Post Transfusion Capillary Blood Flow: https://www.youtube.com/watch?v=wyshSIA5nNk

Transfusion in Trauma

The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. J Trauma. 2007 Oct;63(4):805-13. PMID: 18090009

Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer? Kashuk JL, Moore EE, Johnson JL, Haenel J, Wilson M, Moore JB, Cothren CC, Biffl WL, Banerjee A, Sauaia A. J Trauma. 2008 Aug;65(2):261-70; discussion 270-1. doi: 10.1097/TA.0b013e31817de3e1. PMID: 18695460

Impact of plasma transfusion in trauma patients who do not require massive transfusion. Inaba K, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Teixeira PG, Shulman I, Nelson J, Demetriades D. J Am Coll Surg. 2010 Jun;210(6):957-65. doi: 10.1016/j.jamcollsurg.2010.01.031. Epub 2010 Apr 28. PMID: 20510805

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. Lancet. 2010 Jul 3;376(9734):23-32. doi: 10.1016/S0140-6736(10)60835-5. Epub 2010 Jun 14. PMID: 20554319

Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Arch Surg. 2012 Feb;147(2):113-9. doi: 10.1001/archsurg.2011.287. Epub 2011 Oct 17. PMID: 22006852

The PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study. Holcomb JB, Fox EE, Wade CE; PROMMTT Study Group. J Trauma Acute Care Surg. 2013 Jul;75(1 Suppl 1):S1-2. doi: 10.1097/TA.0b013e3182983876. PMID: 23778505

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group. JAMA. 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203

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  504k v. 1 Dec 8, 2016, 2:05 PM Kit Tainter
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2016 pts, hip fractures, CV dz, equal outcomes for Hb >8 or >10   495k v. 1 Sep 17, 2013, 3:55 AM Kit Tainter
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  636k v. 1 Feb 22, 2015, 10:58 AM Kit Tainter
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  213k v. 1 Jan 28, 2015, 3:41 PM Kit Tainter
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  429k v. 1 May 28, 2014, 11:58 AM Kit Tainter
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PRBCs <10 vs >21 days old after cardiac surgery, no difference in adverse events  582k v. 1 Apr 25, 2015, 11:08 AM Kit Tainter
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Hb 9 vs 7.5 after cardiac surgery, only difference was more 90-day deaths in restrictive group  594k v. 1 Apr 4, 2015, 9:57 PM Kit Tainter
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Cardiac surgery Hb 8 vs 10, similar outcomes  478k v. 1 Feb 4, 2014, 2:26 PM Kit Tainter
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418 pts, Hb > 7 vs > 10, improved mortality (18 vs 23% ns), especially with lower APACHE II and age < 55    173k v. 1 Apr 23, 2014, 10:00 AM Kit Tainter
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198 pts Hb 7 vs 9 showed INCREASED mortality with lower threshold  385k v. 1 Jan 23, 2015, 12:33 PM Kit Tainter
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Hb 7 vs 9, mortality 5% vs 9%   617k v. 1 Nov 6, 2013, 10:45 AM Kit Tainter
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Hb 7 vs 9 in septic shock, no difference in outcomes  569k v. 1 Oct 1, 2014, 9:01 AM Kit Tainter
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  45k v. 1 Dec 8, 2016, 10:57 AM Kit Tainter
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