We are now well above 75k exomes and thousands of phenotypes. Work is going very well; we have made major inroads towards understanding the genetic basis of several diseases but have focused largely on immune and cardiometabolic traits in the main. Our first major publication was CLAMMS, by far the most efficient versatile and scalable exome-specific CNV caller out there. Additional publications are in review and I will put the link up when the articles go live. Here's to another great year of great science!
I'm delighted to announce today that I'll soon be starting a new position in the Regeneron Genetics Center as Manager, Statistical Genetics! Will post some updates over the coming months. The overall aim of the company's work will be to leverage human genetics, through exome and related studies and numerous collaborations, to inform on new drug targets. See here for original press release and here for the company's website. Very excited about the challenges and opportunities that lie ahead.
Given that I'm moving to New York, I say "Excelsior!"
Big big news this week in nature. I was a small part of this work. I believe there's still about 15-20 years ahead before we have new families of genetics-informed drugs for schizophrenia, but this is a major advance. It's sort of a human genome project for schizophrenia, identifying a large number of the genes implicated in the condition and setting forth an initial road map for drug development.
To give you a context of how rapid we got here:
Other media appearances:
NY Times article here
BBC article here
Time article here
Boston Globe article here
Science news article here
The Scientist article here
LA Times news article here
Check it out here: http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.2742.html
Broad blog post here: http://www.broadinstitute.org/blog/rooting-out-schizophrenia
Article in science daily: http://newsle.com/article/0/89916905/
Once of my resolutions will be to actually update this site at a reasonable rate...
Workwise, on the immediate horizon are:
- lots of new GWAS significant candidates for schizophrenia will be published by the Swedish Schizophrenia consortium and then later by the PGC (psychiatric GWAS consortium)
- the Swedish group are also working on copy-number variation in about 11,000 individuals. Some interesting results have emerged so far but we're a few months off a viable paper. Stay tuned.
(follow @codushlaine on Twitter for work updates)
- some big motorcycle trips planned - Ohio and Atlanta
- I'm the best man for my brother's wedding in August, in Poland, whoohoo!
- Working full time at the Broad now, going very well
- Working on pooled sequencing data this week
- got my 23andme results...very exciting!
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