Dr. Cristina Murga Montesinos

Dr. Cristina Murga 

Associate Professor

Departamento de Biología Molecular




Link to a series of microvideos that respond to eight important questions about Cell Biology and explain some of the research lines in our Center (audiovisual project Coordinated by Cristina Murga in 2016):



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In the area of Biomedicine, I hold ongoing or already finished granted projects on the following subjects:

1.- general cell signaling (GPCR research, survival routes, signaling mechanisms),

2.- molecular bases of certain aspects of cardiovascular disease (cardiac hypertrophy, cardioprotection, hypertension),

3.- molecular bases of insulin resistance, obesity and other pathologies with a metabolic component in transgenic mouse models.

4.- sexual dimorphism in cellular and molecular signaling networks implicated in differential pathological risk between males and females.


Dr. Cristina Murga is natural from Spain and graduated in Biochemistry and Molecular Biology by the Universidad Autónoma de Madrid (UAM). She received a National Graduation award in 1992, and obtained her PhD in 1996 working on G protein Coupled Receptor Kinase subcellular localization by describing a pool of the protein in intracellular membranes that had been previously unappreciated.

Next Dr. Murga performed a postdoctoral stay of  5 years at Dr. Silvio Gutkind's laboratory at the NIH in Bethesda (Maryland, USA) where she characterized the activation of Akt by GPCRs, and also described novel roles of several PI3K isoforms in the transduction of G protein-dependent signals.

Currently she holds an Associate Professorship at the UAM and was deputy director of the Centro de Biología Molecular "Severo Ochoa" until 2019. Her current research interests relate to the cellular and molecular biology of several signal transduction pathways, with particular focus on the physiopathological implications of altered signalling routes.

Dr. Murga has supervised 6 PhD thesis (two more ongoing) and also leads an experimental team with several ongoing research projects granted by the Science Spanish Ministry related to the study of the signaling networks implicated in the development of insulin resistance and in the regulation of obesity and adiposity using murine model systems (aging and high fat feeding) and also human samples. We also study the differential control of cardiovascular risk related to insulin signaling in male versus female mice (sexual dimorphism).

Our group has also 3 patents related to inhibitors of p38 MAPKinase with analgesic and anti-inflammatory effects.