Dr. Cristina Murga Montesinos

Dr. Cristina Murga 

Vicedirector, Centro de Biología Molecular “Severo Ochoa”. 

Associate Professor. 

Departamento de Biología Molecular


Link to a series of microvideos that respond to eight important questions about Cell Biology and explain some of the research lines in our center (audiovisual project Coordinated by Cristina Murga in 2016):



Updated global Research and Teaching profile

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- Implication of GRK2 in adiposity, obesity and glucose intolerance-related diseases.

- Cell signaling regulation by GRK2 involved in cardiac hypertrophy and vascular function.

In the area of Biomedicine, I hold ongoing or already finished granted projects on the following subjects:

1.- general cell signaling (GPCR research, survival routes, signaling mechanims),

2.- molecular basis of cardiovascular disease (cardiac hypertrophy, cardioprotection, hypertension),

3.- molecular basis of diabetes / obesity and metabolic diseases (resistance to develop obesity and insulin resistance in several transgenic mouse models).


Dr. Cristina Murga is natural from Spain and graduated in Biochemistry and Molecular Biology by the Universidad Autónoma de Madrid (UAM). She received a National Graduation award in 1992, and obtained her PhD in 1996 working on G protein Coupled Receptor Kinase subcellular localization by describing a pool of the protein in intracellular membranes that had been previously unappreciated

Next Dr. Murga performed a postdoctoral stay of  5 years at Dr. Silvio Gutkind's laboratory at the NIH in Bethesda (Maryland, USA) where she characterized the activation of Akt by GPCRs, and also described novel roles of several PI3K isoforms in the transduction of G protein-dependent signals. 

Currently she holds an Associate Professorship at the UAM and is deputy director of the Centro de Biología Molecular "Severo Ochoa". Her current research interests relate to the cellular and molecular biology of several signal transduction pathways, with particular focus on the physiopathological implications of altered signalling routes in which the kinase GRK2 is implicated. 

Dr. Murga has already  supervised four PhD thesis (two more ongoing) and also leads a research team with several ongoing research projects granted by the European Foundation for the Study of Diabetes, the Fundación Ramón Areces and the MINECO Spanish Ministry related to the study of the implications of GRK2 in the development of insulin resistance, control of insulin signaling and in the regulation of obesity and adiposity using murine model systems (aging and high fat feeding) and also in human samples. The goup has also patented inhibitors of p38 MAPK with analgesic and anti-inflammatory effects.