MyoSim version 2.4 and later can run simulations with parameters that depend on the prevailing half-sarcomere length. Specifically, parameter y can be scaled from its initial value y0 by the factor r as follows y = y0 * (1 + r * (hsl - initial_hsl)/initial_hsl)) where hsl is the current half-sarcomere length and initial_hsl is the half-sarcomere length at the beginning of the simulation. The r values are set for each simulation using MyoSim normal's approach for adjustable parameters. See further down this page for an example. Thin filament parameters
Rate constants You can make the parameter for a rate function length-dependent using the tag ld_rate@x@y. Note that this modification slows down the simulations because the rate matrix has to be recalculated every iteration. Examples Assume:
With these values
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Variables >