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Darartu Gamada

Project Summary
When kidney disease causes renal failure, a patient must receive either dialysis treatments or a transplant kidney. This study reports genetic and molecular mechanisms that lead to antibody-mediated rejection (ABMR) after kidney transplantation. The Gene Expression Omnibus was used to identify differentially expressed genes in ABMR compared to acute cellular rejection (ACR), kidney damage but no rejection (NR), and healthy kidney transplants (control). R-script was written to cross match genes identified for the ABMR group with genes identified for ACR, NR, and control groups to isolate genes specific to ABMR. Given interest in determining if Kruppel-like factor 4 (KLF4) is a viable biomarker for ABMR, R-script was written to cross-match genes specific to ABMR with genes regulated by KLF4; results support the case for KLF4 as a biomarker for ABMR. To understand functions of identified genes, the top ten biological pathways and ontologies for ABMR genes were identified using Enrichr libraries. Finally, genes specific to ABMR were correlated with experimentally vetted drug candidates in the LINCS L1000 dataset from which the top ten drug candidates for ABMR were generated. This work may lead to the development of treatments for kidney rejection.
Darartu Uchiha

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Honors & Awards
Darartu Gamada (2016) worked in the Department of Medicine at Stony Brook University under the guidance of Dr. Sandeep Mallipattu. Darartu participated in the Twin Cities regional science fair, and her research paper qualified her for the North Central Tri-State JSHS competition. She observed the Minnesota State Science and Engineering fair, and competed in Tri-State JSHS. Darartu will be attending Harvard University.