Summit Schedule

The 7th Annual California ALS Research Summit will be held at the Aresty Auditorium, 1450 Biggy Street, Los Angeles, CA 90089, on the campus of the Keck School of Medicine of University of Southern California (USC).

This year’s agenda will be organized around specific themes that are relevant to the consortium as basic science and/or clinical topics.  Each theme will be initiated by a platform talk (30-40 min) followed by an open panel discussion (60 min or more).  The panel will be provided several points to trigger discussion with the expectation of a dialogue between attendees and the panel.  


Summit Schedule (as of 1.5.17)

DAY 1:               Friday, January 13, 2017


7:45 – 8:10 a.m.    Registration and Breakfast   


8:10 – 8:20 a.m.    Welcome to USC, Conference Overview

  • Justin Ichida, PhD,  Local Chair, USC

  • Clive Svendsen, PhD, Chair, California ALS Research Network; Director, RMI, Cedars-Sinai

  • Robert Miller, MD, Medical Director, Forbes Norris ALS Treatment and Research Center, CPMC

  • Fred Fisher, MSW, LCSW, President & CEO, The ALS Association Golden West Chapter

8:20 – 9:40 a.m.      Theme I: Clinical Trials – (20 minutes each)

  • FDA Guidance and New Guidelines – Lucie Bruijn, PhD, The ALS Association

  • BMAA and Edavarone – Robert Miller, MD, Forbes Norris MDA/ALS Research Center; Jean Hubble, MD, VP Medical Affairs, MT Pharma America Ink

  • The assessment of bulbar function: what do the patients have to say? – Richard Smith, MD

  • Retigabine Trial - Brian Wainger, MD, PhD, MGH

9:40 – 10:00 a.m.      Discussion


10:00 – 10:15 a.m.    Break


10:15 – 11:35 a.m.    Theme II: Big Data and ALS  – What are the Prospects?  (20 minutes each)

  • Answer ALS – Clive Svendsen, PhD, Cedars-Sinai

  • Machine Learning – Steve Finkbeiner, MD, PhD, Gladstone Institutes

  • RNA interactions and liquid-liquid phase states in neurodegeneration  – Kenneth S. Kosik, MD, UCSB

  • A Systems Genetics Approach to Neural Repair– Dan Geschwind, MD, PhD, UCLA

11.35 – 11.45 am    Discussion           


11:45 – 12:45 p.m.  Lunch


12:45 – 1:45 p.m.    Theme III: Research – Organ-on-a-chip and Organoids (20 minutes each)

  • 3D Organoids – Ben Novitch, PhD, UCLA

  • Engineering Skeletal Muscle on a Chip – Megan McCain, PhD, USC

  • Dysfunctional bioenergetics and amino acid metabolism in C9orf72 ALS: clues to better models of a diseased neuromuscular junction-on-a-chip – Dhruv Sareen, PhD, Cedars-Sinai


1:45 - 2:00 p.m.     Discussion


2:00 – 2:15 p.m.    Break


2:15 – 3:00 p.m.    Theme IV: Neuroinflammation (20 minutes each)


  • Inflammation and C9orf72 – Robert Baloh, MD, PhD, Cedars-Sinai

  • Role of Microglia in FTD and Neurodegeneration – Eric Huang, MD, PhD, UCSF


3:00 – 3:15 p.m.     Break


3:15 – 4:30 p.m.    Updates from industry (15 minutes each)

  • Verge Genomics – Alice Zhang PhD, CEO

  • Cytokinetics – Jinsy Andrews, MD        

  • Mallincrodkt - Susan VanMeter, Senior Director, Clinical Research at Mallinckrodt Pharmaceuticals, Inc

  • Neuraltis -  Robert Miller, MD, Forbes Norris MDA/ALS Research Center

4:30 – 4:50 p.m.     Panel Discussion:

   Academia-industry collaborations – Opportunities and Challenges


6:00 p.m.               Cocktail Reception at the Millennium Biltmore Hotel, sponsored by Duane Morris, LLP


6:50 p.m.               Special performance by Zora Mihailovich, pianist

  • R. Schumann - Kinderszenen (Scenes from Childhood) Op. 15
  • Riccardo Pick Mangiagalli - Dance d’Olaf - “Deux Lunaires” Op. 33

7:20 p.m.               Dinner begins


7:50 p.m.               Special Presentations
  • Overview of the 21st Century Cures Act  - Vicki Norton and Ryan Smith, Duane Morris, LLP

  • Remembering Jim Barber and the launch of the annual Barber ALS Research Award

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DAY 2:             Saturday, January 14 , 2017

7:45 – 8:15 a.m.    Breakfast at Aresty Auditorium, sponsored by Option Care.


8:15 – 9:15 a.m.    Theme V:  C9ORF and genetics updates (20 minutes each)

  • ASO’s – Don Cleveland, UCSD

  • Drug targets for ALS – Aaron Gitler PhD, Stanford

  • Role of C9ORF72 function in ALS– Justin Ichida, PhD, USC


9:15 9:30 a.m.        Panel discussion


9:30 9:45 a.m.        Break


9:45 10:45 a.m.     Theme VI:  Brain Machine Interfaces (20 mins each)

  • Controlling a robotic arm with a patient’s intentions – Richard Andersen, PhD, Caltech

  • Surgical aspects of brain-machine interfaces – Charles Liu, MD, USC

  • Brain-driven movement of prosthetics in monkeys and humans - Maryam Shanechi, PhD, USC


10:45 – 11:00 a.m.    Panel discussion:  When can brain machine interfaces be used in the clinic?

   

11:00 – 11:15 a.m.    Break


11:15 – 11:45 a.m.   Updates from the California Institute for Regenerative Medicine

  • EXCITING NEWS! A new, approved gene and stem cell therapy trial for ALS
    Lila Collins, PhD, Senior Science Officer, Therapeutics
    Clive Svendsen, PhD, and Robert Baloh, MD, PhD, Cedars Sinai


11:45 – 12:00 p.m.    Rapid Fire Poster Presentations (3 minutes each) - Five will be selected


12:00 –  1:30 p.m.     Lunch / Poster presentation


1:30 – 2:50 p.m.        Theme V: Emerging tools and mechanisms (20 minutes each)


  • Blood Brain Barrier and Neurodegenerative disease – Berislav Zlokovic, MD, PhD, USC

  • ALS and BBB-on-Chip – Samuel Sances, Cedars-Sinai

  • NMJ alterations in C9 flies – Dion Dickman, PhD, USC

  • ALS Stem Cell Models: from Bench to Bedside and Back –  Brian Wainger, MD, PhD, MGH

2:50 – 3:00 p.m.     Break


3:00 – 3:45 p.m.     Keynote Speaker: Larry Goldstein, UCSD

                                      Using stem cells to model and treat neurodegenerative diseases


3:45 – 3:55 p.m.     Presentation of the Barber ALS Research Award


3:55 – 4:15 p.m.     General discussion and new directions for the California ALS Research Network

4:30 – 6:00 p.m.    Ask the Experts: Research Developments”
                                     Educational symposium for public held at CIRM Building

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