LIFT -  Lutetium-177, Iodine-131 Fluorine-18 and Technetium-99m are possibly going to be the prime radionuclides to be discussed in the first phase.. there possibly could be many more radioisotopes chiefly especially Y-90, Sm-153, P-32 which could be considered for their therapeutic potentials and Ga-68 for PET applications. Someday we may also further discuss brachytherapy applications using Cs-137, Ir-192, Pd-103 and I-125. Possibly on a later date one of the promising alpha emitting radioisotope for targeted alpha therapy namely Bi-213 might also find a page for itself.

May 31 2015 - The website though far from complete is now open for the public view.. Please give me little more time to get more information related to breast cancer. The good news is that American Cancer Society has some important pages listed in Hindi.. I did find it very interesting.. Now I do not really have to provide the basic breast cancer information in Hindi.. as it is already available on the ACS website. I shall concentrate on recent advances and trends in breast cancer research - my major area of interest shall be Molecular Imaging for Breast Cancer, Quantum dots, and radionuclide therapy applications in cancer.

Maybe some of you would love to read a little more about the Hallmarks of Cancer. Professor Robert Weinberg of MIT first published a comprehensive view on the subject in the journal Cell in the year 2000 and the Next Generation article was published in the same journal in 2011 (The link to his revised article)

What is Cancer ?

Cancer is one of the most dreaded disease that often terminates with the death of the inflicted individual. Cancer is a cell level disease where somehow one of the cell becomes cancerous  and multiplies to develop into a carcinoma or a tumor. The exact reasons for the cell loosing its normal controls and turning into a cancer are not known with much certainty. Some of the cancers are curable if detected early. Some of the cancers may be related to genetic pre-disposition of individuals. A few types of cancers could be related to personal habits such as smoking and occupational exposures to some known carcinogens. 

Professor Sanjiv Sam Gambhir of Stanford University School of Medicine with his deep rooted interests in imaging technologies especially the upcoming with quantum dots, fluorescence based technologies and huge expertise in nuclear medicine imaging esp. the PET with all its added arms like PET/CT PET/MRI and maybe I could include immunoPET and microPET to the league.. should be my guiding factor even if we do not really know each other.. 

These next five years I should be doing just one thing.. read everything about breast cancer.. focus myself on FIBRE i.e. [18F] Fluorine Labelled PET radiopharmaceuticals for Imaging  applications in Breast Cancer Research.. possibly evolve interest in finding a few suitable and sensitive markers for some of the breast cancers.. that could be tagged along to the QDs for non-expensive diagnosis, imaging and therapy (QDIT)
Advancements : Updated May 15 0031
Cancer is not a single disease but really quite a heterogeneous one at molecular level.. even breast cancer subject of my personal interest has quite a few of its own kind.. further there could be subtypes among the specific ones.. to address the issue at molecular or genomic level does raise some hopes yet really just how much is to be seen..  till we get some meaningful data emerging from voluminous sequencing variations.. 

Breast Cancer 
Much of the present research is just trying to get somewhere where one could seek some of the partial answers.. to origins, manifestation and future course of the disease.. to find biomarkers.. to correlate the findings with the treatments.. to monitor the progress and maybe try to understand the recurrence and or metastasis of the primary cancer to new locations..

Who knows that with the advent of quantum dots we may just start to order the events with a bit more certainty.. though the present expensive and in-depth research does open up hopes of our better understanding the disease yet in most cases personal complete sequencing of the genome could probably never be in place for a country like say India or Pakistan.. we would really need to come down to single or maybe fewer than 4-5 tests mostly interdependent or related in some ways to get the best out of breast cancer DNA.. Targeting breast cancer stem cell could be that last hope to find a cure.. 

Molecular pathways (or rather portraits to sound similar ) associated with breast cancer were reviewed in Nature by the Cancer Genome Atlas Network in 2012.. There were such vast statistical differences that it may look herculean task to derive some meaningful data from there yet that alone is probably the way.. that is only the beginning.. we have to start assigning meanings and assembling events possibly with their interplay rather than seeing or looking at them singly.. amplifications to me appear to be more significant than may be the SNPs though SNPs themselves or similar variations could be at the backbone of the amplifications.. the proteomic part also seems to be as much significant.. it isn't a chance that we have ER /PR and HER2 positive cancers to begin with.. to me it appears that the role of these receptors fades and maybe they are sort of thrusted out of the evolving cell in follow up of more events which now could be mutations which probably were not present to begin with but emerged after interventions.. 

With the advancements in science specifically molecular biology and bioinformatics our understanding of cancer has definitely improved over the last decade. I am still afraid if the malignant type could be controlled over long periods yet the quality of life and management of cancer patients  has made tremendous progress at least in few of the cancers. Breast Cancer does fall in that category though the availability and accessibility of such treatment comes at some high cost. It would still take some time for these rapid advancement to reach common citizen. A knowledge about better personal management of one's cancer could sure make an impact in the quality of life and extending disease/progression free survival of an individual.

Cancer is too much of a multi-disciplinary research subject in nature - depending on too many broad subjects of Cell Biology (chromosomes, cellular organization, membranes and cytogenetics, cell-environment interactions), Molecular Biology (The gene, DNA, RNA, Proteins their regulations, chemistry and structures), Bioinformatics (Computer Applications for DNA and protein sequences), Chemotherapy (Chemistry of rational drug design). In many cases surgery, pathology, radiology and even radiotherapy also play a significant role. I understand it is a bit too late for me to get directly involved and make any significant contributions yet I believe someday someone with available time and inclination to do so might find the information here somewhat useful.  

There has been a tremendous body of work in our fight against cancers, and maybe there has been a great national and philanthropic funding towards our understanding of the dreaded disease compared to past , say before the structure of DNA became known in 1953. Yet Cancer has not provided much clues to its origin and complete cure. Cancer Prevention is a far fetched dream and I believe it seems impractical given the surroundings a human living cell faces in the modern world of scientific and technological advancement and with ageing, with our present knowledge we can at best manage it as well as we can. True we have substantially advanced our knowledge and the quality of life among cancer patients notably in prolongation of survival in several patients with many different types of cancer, however, the battle against cancer is far from over. I hastily add though that some of the cancers if detected early and if treated adequately may appear as if treated and cured permanently. Breast cancer (among major cancer types) is likely to fall in this special category in very near future. This could possibly explain my interest in the subject besides the obvious Dr. Mittra connection. 

What interests me about Cancer ? 

I would first like to understand more about the management of cancer of atleast one kind and identify conditions that could help Physicians help their patients help themselves in fighting the disease with right perspective. Secondly there is every likelihood that I would develop cancer someday owing to my exposure to tobacco in the form of smoking. I can not remain blind to the overwhelming cases of tobacco being indicative of chances of individuals developing cancers of one kind or the other.. 

The other reasons are of philanthropic nature.. I would consider myself fortunate if I could help spread awareness about Cancer for the benefit of those who may suffer with cancer. 

What are the aims and objectives of this website?

The aims and objective are to provide links to articles and cancer related websites. Much information and facts are available in scientific and medical literature and now on the internet. Much of it is available in English and one still needs to  know where to exactly looks for right information. Since my introduction to Cancer had initiated with Dr. Indraneel Mittra. This website would primarily provide links and/or information related to his body of work on Breast Cancer.

I might also focus on Chronic Myeloid leukemia (CML) later.  

I would be glad if I could devote some time to present a few articles on Cancer in Hindi for a better understanding by a large section of people in India. When and on what aspects would I be able to provide useful articles in Hindi can not be said with much certainty. I do intend to approach National Cancer Institute and International Atomic Energy Agency on this subject and maybe find time or means to translate some of the much incredible information available on their websites into Hindi.

The Role of BRIT

I would try to include links to radiation therapy for cancer treatment and possibly give some insights on brachytherapy. BRIT supplies Cobalt Teletherapy Sources (CTS) for external beam radiation therapy for Bhabhatron and other teletherapy machines in treatment of cancer. The use of other radioisotopes used in diagnostic practices prevalent in Nuclear Medicine for management of Cancer could also find some space here.

Abhaya - July 11 2012
 My interactions with Cancer dates back to over 20 years when I was staying at Anand Bhavan and when I first met Dr. Indraneel Mittra. Dr. Mittra was the top breast cancer surgeon and expert at Tata Memorial Hospital. Two young sons of Dr. Mittra, Bikram and Arjun used to come to 15 Anand Bhavan to play with me. I did visit his Department of Laboratory Medicine at the seventh floor of TMH. I did interact with Dr. Alka Redkar and Dr. Dilip Bandopadhyay on a couple of occasions.

For some reasons I moved to Anushakti Nagar and the cancer connection almost came to a halt. I had ventured into a computer language Prolog and wanted to be of some help to Dr. Mittra in some ways. I had thought of designing a Cancer counselling program for cancer patients in the country, his initial reaction was  little furious.. I remember he had said we do not have vitamins and medicines for patients and I was thinking of counselling. Somehow it reminded me of Dr. Bhaskar Banerjee of Anand. Later he did ask me to look up into the Statistics software and if I could be of some help to the Computer centre at TMH for its utilization. I was then working at Navi Mumbai and usually returned home late. A good opportunity to work with an FRCS had fizzled out.

I dedicate this website to Cancer especially to Breast Cancer  as practised by Professor Mittra. I know it is too late for me to make some useful contributions yet I shall try to put my best foot forward in the defence against Cancer.

Subpages (1): TMC_Hindi