Speaker: Tetsuya Kobayashi

Date: Mar. 6th (Wed.) 16:00- 17:00

Style: Zoom

Title: Theory and thermodynamics of chemical reaction networks

Abstract: Cells, the fundamental units of life systems, are shaped by the networks of chemical reactions, from which various functions are realized through the dynamics of these reaction networks. Moreover, many of these reactions are considered to be non-equilibrium, making the understanding of the thermodynamic costs and constraints involved in these functions a significant challenge in biophysics. Chemical thermodynamics and chemical kinetics, established almost simultaneously over a century ago, along with the recent developments in stochastic thermodynamics, might suggest that a comprehensive understanding of these areas could have been achieved by now. However, chemical reaction systems fall into the category of interacting particle systems rather than the independent particle systems primarily dealt with in stochastic thermodynamics, encompassing nonlinear properties and having nonlinear constitutive equations for forces and flows. Chemical reaction networks, which encompass various unresolved issues, have recently been the focus of simultaneous and parallel research in multiple fields such as stochastic thermodynamics, systems biology, control theory, algebraic geometry, and large deviation theory. This presentation aims to overview the current state of theories and thermodynamics of chemical reaction networks, considering their historical context, and introduce the information geometric structure of non-equilibrium chemical reaction systems that we propose as an integration of these theoretical studies.