We are interested in fundamental aspects of metabolic regulation, particularly how diet and environment influence the co-morbidities of obesity and other energy balance disorders. Recent efforts in our laboratory use modern combinations of mouse and human studies to examine the cell biology within metabolic tissues and identify new modes of endocrine communication in the periphery. Our laboratory receives support from NIH R01DK114356, NIH R01DK138018, and NIH R01DK139397. The Cellular and Molecular Metabolism Core is part of the Houston Nutrition and Obesity Research Center and supported by NIH P30DK144025.