My personal research oriented website
Charlotte de Blois
Welcome !
I am doing a Post-Doc in the Physique department of ENS Paris and ESPCI Paris, PSL University, on diffusio-osmotic mixing for blue energy optimization
.
I am looking for an assistant professor/researcher job in academia.
December 2023 : Breaking News
My new paper is out ! Learn more about the work I conducted at ENS de Lyon and université de Lyon, IMAP...
Optical single molecule characterisation of natural and synthetic polymers through nanopores
Charlotte de Blois, Marie Engel, Marie-Amélie Rejou, Bastien Molcrette, Arnaud Favier and Fabien Montel
Nanoscale, Find it here
Nanopore techniques are now widely used to sequence DNA, RNA and even oligopeptide molecules at the base pair level by measuring the ionic current. In order to build a more versatile characterisation system, optical methods for the detection of a single molecule translocating through a nanopore have been developed, achieving very promising results. In this work, we developed a series of tools to interpret the optical signals in terms of the physical behaviour of various types of natural and synthetic polymers, with high throughput. We show that the measurement of the characteristic time of a translocation event gives access to the apparent molecular weight of an object, and allows us to quantify the concentration ratio of two DNA samples of different molecular weights in solution. Using the same tools for smaller synthetic polymers, we were able to obtain information about their molecular weight distribution depending on the synthesis method.
April 2023 : Breaking News
I will be presenting my paper in the Physical Review Journal Club !
Topic: PRFluids Journal Club - April
Time: Apr 28, 2023 03:00 AM Eastern Time (US and Canada) - 9h in France
Join Zoom Meeting:
https://apsphysics.zoom.us/j/82548252771?pwd=eXNTOXhHS29oZUZpam9JQ3I1emtxUT09
Meeting ID: 825 4825 2771
Passcode: 949317
In a viscoelastic flow over a microfluidic canopy of polymeric pillars, we report the spontaneous emergence of waves in the form of propagating regions of low flow velocity compared to the surrounding flow. The occurrence of the wave is chaotic and shows characteristics of elastic turbulence. We systematically study the coupling between the low velocity wave and the microfluidic canopy by combining flow velocimetry experiments and high speed tracking of the pillars. The waves form an angle ±β with the primary flow direction that depends on the geometry of the pillar array. If the canopy is composed of flexible structures, the passage of a wave deflects the structures locally in a manner reminiscent of the emergence of the Monami waves observed in inertial turbulence over canopies of vegetation. Due to the analogies with classical (inertial) canopy turbulence, we name our newly-observed phenomenon as canopy elastic turbulence.