Yun Xiang, Ph.D.
Professor
School of Chemistry and Chemical Engineering
Southwest University
Chongqing, 400715 China
Email：yunatswu@swu.edu.cn
Education：
Ph.D. in Chemistry Arizona State University 2008 (Advisor: Prof. Joseph Wang)
M.S. in Chemistry Sichuan University 2003
B.S. in Chemistry Sichuan University 1999
Working Experience：
Professor Southwest University 2011
Assistant Professor Southwest University 2009-2011
Research Assistant Arizona State University 2005-2008
Teaching Assistant New Mexico State University 2003-2004
Grant Awards：
National Natural Science Foundation of China 2021-2025
National Natural Science Foundation of China 2017-2020
National Natural Science Foundation of China 2013-2016
The New Century Excellent Talent Program, Ministry of Education 2013-2015
National Natural Science Foundation of China 2010-2012
Natural Science Foundation of Chongqing 2009-2012
Research Interest：
1. Development of ultra-sensitive biosensors for the detection of biomarkers
2. DNA self-assembly and DNA nanostructures for sensing, cell imaging and drug delivery
Recent Key Publications out of 200+
1. Fang Yang, Shunmei Li, Xin Bi, Ruo Yuan, Yun Xiang,* DNA-Assembled Size-Permeable Microcapsule Bioreactor Enables Direct and Rapid Sensing of Trace Circulating MicroRNA Biomarker in Undiluted Cancer Patient Serum, Analytical Chemistry, 2025, doi/10.1021/acs.analchem.4c05330.
2. Xinmei Song, Yuan Ming, Juan Liu, Bingying Jiang,* Ruo Yuan, Yun Xiang,* Highly catalytic CoFe-prussian blue analogue/ZIF-67 yolk-shell nanocube-decorated MBene nanosheets for ultrasensitive electrochemical cancer-specific neoantigen biosensor, Journal of Colloid and Interface Science, 2025, 683, 58–67.
3. Shunmei Li , Fang Yang , Xin Bi , Ruo Yuan , Yun Xiang,* Protein-bridged size-permeable DNAzyme@PEG hollow nanosphere reactor facilitates direct and rapid monitoring of trace circulating microRNAs in undiluted cancer patient serums, Chemical Engineering Journal, 2024, 500, 156649.
4. Daxiu Li,* Yinghan Liu, Yuhao Li, Yun Xiang,* Ruo Yuan, Simultaneous and Sensitive Sensing of Intracellular MicroRNA and mRNA for the Detection of the PI3K/AKT Signaling Pathway in Live Cells, Analytical Chemistry, 2024, 96, 3329−3334.
5. Qirong Chen, Jinglan Cao, Yi Zhao, Bingying Jiang,* Ruo Yuan, Yun Xiang,* Highly catalytic sulfur-doped and bimetal-coordinated CoFe(CN)5NO nanoparticles coupled with PER/HCR amplification cascades for sensitive electrochemical aptamer luteinizing hormone assay, Biosensors and Bioelectronics Biosensors & Bioelectronics, 2024, 261, 116473
6. Fang Yang, Shunmei Li, Xin Bi, Ruo Yuan, and Yun Xiang,* Multicolor-Encoded DNA Framework Enables Specific and Amplified In Situ Detection of the Mitochondrial Apoptotic Signaling Pathway, Analytical Chemistry, 2023, 95, 12514−12520.
7. Fang Yang, Shunmei Li, Xia Li, Ruo Yuan, and Yun Xiang,* Robust DNA Cross-Linked Polymeric Lighting-Up Nanogel Facilitates Sensitive Live Cell MicroRNA Imaging, Analytical Chemistry, 2022, 94, 16079−16085.
8. Xia Li, Fang Yang, Chunfang Gan b,* Ruo Yuan, Yun Xiang,* Sustainable and cascaded catalytic hairpin assembly for amplified sensing of microRNA biomarkers in living cells, Biosensors & Bioelectronics, 2022, 197, 113809.
9. Feng Qiu, Xiaoyan Gan, Jianglong Yao, Bingying Jiang,* Ruo Yuan, Yun Xiang,* CRISPR/Cas12a-derived sensitive electrochemical biosensing of NF-κB p50 based on hybridization chain reaction and DNA hydrogel, Biosensors & Bioelectronics, 2022, 216 (2022) 114665.
10. Wenjiao Zhou, Fang Yang, Shunmei Li, Ruo Yuan, Yun Xiang,* A stimulus-responsive hexahedron DNA framework facilitates targeted and direct delivery of native anticancer proteins into cancer cells, Chemical Science, 2022, 13, 11132–11139.
11. Xia Li, Fang Yang, Shunmei Li, Ruo Yuan, Yun Xiang,* Size-discriminative DNA nanocage framework enables sensitive and high-Fidelity imaging of mature microRNA in living cells, Analytical Chemistry, 2022, 94, 9927−9933.
12. Fang Yang, Xia Li, Ruo Yuan, Yun Xiang,* High fidelity and simultaneous sensing of endogenous mutant and wild p53 proteins for precise cancer diagnosis and drug Screening, Analytical Chemistry, 2021, 93, 8084−8090.
13. Xia Li, Fang Yang, Wenjiao Zhou, Ruo Yuan, Yun Xiang,* Targeted and direct intracellular delivery of native DNAzymes enables highly specific gene silencing, Chemical Science, 2020, 11, 8966-8972.
14. Jianmei Yang, Xiaolong Li, Bingying Jiang,* Ruo Yuan, Yun Xiang,* In Situ-Generated Multivalent Aptamer Network for Efficient Capture and Sensitive Electrochemical Detection of Circulating Tumor Cells in Whole Blood, Analytical Chemistry, 2020, 92, 7893−7899.
15. Daxiu Li, Tingting Zhang, Fang Yang, Ruo Yuan,* Yun Xiang,* Efficient and Exponential Rolling Circle Amplification Molecular Network Leads to Ultrasensitive and Label-Free Detection of MicroRNA, Analytical Chemistry, 2020, 92, 2074−2079.
16. Baoting Dou, Jin Li, Bingying Jiang,* Ruo Yuan, Yun Xiang,* DNA-templated in situ synthesis of highly dispersed AuNPs on nitrogen-doped graphene for real-time electrochemical monitoring of nitric oxide released from live cancer cells, Analytical Chemistry, 2019, 91, 2273−2278.
17. Wenjiao Zhou, Daxiu Li, Ruo Yuan, Yun Xiang,* Programmable DNA ring/hairpin-constrained structure enables ligation-free rolling circle amplification for imaging mRNAs in single cells, Analytical Chemistry, 2019, 91, 3628−3635.
18. Baoting Dou, Lin Xu, Bingying Jiang,* Ruo Yuan, Yun Xiang,* Aptamer-functionalized and gold nanoparticle array-decorated magnetic graphene nanosheets enable multiplexed and sensitive electrochemical detection of rare circulating tumor cells in whole blood, Analytical Chemistry, 2019, 91, 10792−10799.
19. Yao Qin, Daxiu Li, Ruo Yuan, Yun Xiang,* Netlike hybridization chain reaction assembly of DNA nanostructures enables exceptional signal amplification for sensing trace cytokines, Nanoscale, 2019, 11, 16362−16367.
20. Xia Li, Jianmei Yang, Ruo Yuan, Yun Xiang,* Programming cascaded recycling amplifications for highly sensitive and label-free electrochemical sensing of transcription factors in tumor cells, Biosensors and Bioelectronics, 2019, 142, 111574.
21. Jianmei Yang, Xiaotong Huang, Chunfang Gan,* Ruo Yuan, Yun Xiang,* Highly specific and sensitive point-of-care detection of rare circulating tumor cells in whole blood via a dual recognition strategy, Biosensors and Bioelectronics, 2019, 143, 111604.
22. Baoting Dou, Jianmei Yang, Ruo Yuan, Yun Xiang,* Trimetallic hybrid nanoflower-decorated MoS2 nanosheet sensor for direct in situ monitoring of H2O2 secreted from live cancer cells, Analytical Chemistry, 2018, 90, 5945−5950.
23. Daxiu Li, Yulan Wu, Chunfang Gan, Ruo Yuan, Yun Xiang,* Bio-cleavable nanoprobes for target-triggered catalytic hairpin assembly amplification detection of microRNAs in live cancer cells, Nanoscale, 2018, 10, 17623.
24. Xia Li, Jianmei Yang, Jiaqing Xie, Bingying Jiang*, Ruo Yuan, Yun Xiang,* Cascaded signal amplification via target-triggered formation of aptazyme for sensitive electrochemical detection of ATP, Biosensors & Bioelectronics, 2018, 102, 296–300.
25. Ying Peng, Daxiu Li, Ruo Yuan, Yun Xiang,* A catalytic and dual recycling amplication ATP sensor based on target driven allosteric structure switching of aptamer beacons, Biosensors & Bioelectronics, 2018, 105, 1–5.
26. Daxiu Li, Wenjiao Zhou, Ruo Yuan, Yun Xiang,* A DNA-fueled and catalytic molecule machine lights up trace under-expressed microRNAs in living cells, Analytical Chemistry, 2017, 89, 9934−9940.
27. Jianmei Yang, Baoting Dou, Ruo Yuan, Yun Xiang,* An aptamer/protein proximity binding-triggered molecular machine for amplified electrochemical sensing of thrombin, Analytical Chemistry, 2017, 89, 5138−5143.
28. Jianmei Yang, Baoting Dou, Ruo Yuan, Yun Xiang,* Proximity binding and metal ion-dependent DNAzyme cyclic amplification-integrated aptasensor for label-Free and sensitive electrochemical detection of thrombin, Analytical Chemistry, 2016, 88, 8218−8223.