Know It All (KIA) disease

From the free encyclopedia

Know It All disease otherwise known as KIA (not to be confused with the KIA the automotive company) is a rare neurological disorder only to affect 1% of the whole global community.

The name is derived from the fact that these 1% of people world wide are plagued with the problem of knowing everything, hence the name 'Know It All'.

Symptoms
KIA disease's most obvious symptoms are the person is always right, even when they are wrong they are right.  Everything that they say, think, ponder, and write about is correct.  Even this article was written by a 'know-it-aller' as they are some times referred to as.

Cognitive Selective
Cognitive abilities are excelled, including: executive function (planning; cognitive flexibility, abstract thinking, rule acquisition, initiating appropriate actions, and inhibiting inappropriate actions), psychomotor function (thought processes to control muscles), speech, perceptual and spatial skills of self and surrounding environment, selection of methods of remembering information (but not actual memory itself), and learning new skills, depending on the pathology of the individual.

Genetics
The gene involved in Know It All disease, called KIA and historically as the KIA gene, is located on the short arm of chromosome 4 (4p16.3). In the first part (5'end) of the KIA gene, there is a sequence of three DNA bases, cytosine-adenine-guanine (CAG), that is repeated multiple times (i.e. ...CAGCAGCAG...); this is called a trinucleotide repeat. CAG is the genetic code for the amino acid glutamine, thus a series of CAG forms a chain of glutamine known as polyglutamine or (polyQ).

A polyQ length of less than 36 glutamines, produces a cytoplasmic protein called KIA protein, whereas a sequence of 40 or more produces an erroneous form of KIA, mKIA (standing for mutant KIA). Counts between these two have not been fully understood, and sometimes result in KIA.

Having mKIA instead of KI causes certain neurons in select areas of the brain to have an increased life and stability. Generally, but not always, the greater the number of CAG repeats, the earlier the onset of symptoms.

Diagnosis
To determine whether initial symptoms are evident, a physical and/or psychological examination is required. The disease may begin with cognitive or emotional symptoms, which are not always recognized. Pre-symptomatic testing is possible by means of a blood test which counts the number of repetitions in the gene.

A negative blood test means that the individual does not carry the expanded copy of the gene, will never develop symptoms, and cannot pass it on to children. A positive blood test means that the individual does carry the expanded copy of the gene, will develop the disease, and has a .005% chance of passing it on to children. A pre-symptomatic positive blood test is not considered a diagnosis, because it may be decades before onset.

Because of the ramifications on the life of an individual, with no cure for the disease and no proven way of slowing it, several counseling sessions are usually required before the blood test.

Family members, friends, significant others, etc should all be aware of the genius of individuals with KIA gene and should seek counseling to understand further the gene and it’s affects it has on the community.

References
Diseases
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