研究計劃

l         比較氟-18-去氧葡萄糖正子彈造影和鎝-99m MDP 骨骼閃爍造影偵測乳癌病人骨轉移的可用性 ( DMR-92-061 )

主持人       2002/7/1-2003/6/30

l         診斷用缺氧性腫瘤細胞的核醫藥劑研製-親脂性鎝氮基亞胺酚系列錯合物的製備研究

主持人       2004/7/1-2005/6/30

l         正一價鎝-99m標誌4N配位子的製備研究 ( DMR-95-076 )

     主持人       2006/7/1-2007/6/30

l         強度調控式放射治療病患臨床劑量之驗證  ( DMR-97-106 )

主持人       2007/7/1-2008/6/30

l         評估非侵襲性生物冷光影像預測游離輻射療效:以NF-κB基因轉殖鼠為模式 ( DMR-98-087 )

主持人       2008/8/1-2009/7/31

l         SMD-2 合併放射線及化學治療頭頸部癌病患對尿中微量元素Cu/Zn及Cu/Se之比值與生活品質及中醫證型變化之評估  ( 行政院衛生署 )

協同主持人  2009/1/21-2009/12/31

發表著作

學術論文

1.         Result of Radiotherapy in the Treatment of Uterine Cervical Cancer and Analysis of Late Rectal Complication (Five Years Experience at SKMH)

Therapeutic Radiololgy and Oncology 1998; 5:11-18

2.         Assessment of Dose Nonuniformity Under Bilateral Opposed Fields for Head and Neck Tumor and Introduction of a Simple Application Model of Tissue Compensator

Therapeutic Radiology and Oncology 1998; 5:157-162

3.         Preliminary Experience of Reducing Bowel Irradiation Volume in the Treatment of Rectal Cancer: Two Cases Study

Therapeutic Radioloy and Oncology, 1999; 6:141-148

4.         Assessment of Dose Perturbation Due to Air Cavity Effects Under Megavoltage Photon Beams

Therapeutic Radiology and Oncology, 1999; 6:49-54

5.         Stereotactic Fractionated Radiotherapy for Trigeminal Neuralgia: a Preliminary Report

Mid-Taiwan Journal of Medicine, 2000; 5(4): 221-227

6.         The Prediction of Late Rectal Complications Following the Treatment of  Uterine Cervical Cancer By High-Dose-Rate Brachytherapy

Int. J. Radiation Oncology Biol. Phys, 2000; 47(4): 955-961  (SCI)  

7.         Differentiating Benign and Malignant Pulmonary Lesions with FDG-PET. Anticancer Research, 2001; 21:4153-4158  (SCI)

8.         Local regional relapse and survival status following postoperative adjuvant radiotherapy for buccal cancer －A preliminary retrospective report.

Jpn Soc Ther Radiol Oncol, 2001; 13, 139-143  (SCI)

9.         Retrospective Comparison of the AJCC 5^th Edition Classification for Nasopharyngeal Carcinoma with the AJCC 4^th Edition: an Experience in Taiwan. Jpn J Clin Oncol, 2001; 31(8), 363-369  (SCI)

10.     Intra-thoracic Failure Pattern and Survival Status Following 3D Conformal Radiotherapy for Non-small Lung Cancer: a Preliminary Report.

Jpn J Clin Oncol, 2001; 31(2), 55-60  (SCI)

11.     Comparing whole body ¹⁸F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphonate bone scan to detect bone metastases in patients with breast cancer.

Journal of Cancer Research and Clinical Oncology, 2002; 128:325-328  (SCI)

12.     Using Technetium-99m-Tetrofosmin Scan to Predict Chemotherapy Response of Malignant Lymphomas, Compared with P-glycoprotein and Multidrug Resistance Related Protein Expression .

Oncology Reports, 2002; 9:307-312  (SCI)

13.     Prediction of Chemotherapy Response in Untreated Malignant Lymphomas Using Technetium-99m Methoxyisobutylisonitrile Scan : Comparison with P-glycoprotein Expression and Other Prognostic Factors. A Preliminary Report .

Jpn J Clin Oncol, 2002; 32(4):140-145  (SCI)

14.     A Dosimetric Comparison of the Predictive Value of Two Rectal Reference Points for Late Rectal Complications Following the Treatment of Cervical Cancer by High-dose-rate Brachytherapy.

Therapeutic Radiology and Oncology, 2002; 9, 41-51

15.     The Role of Thallium-201 Whole Body Scan with Pelvic SPECT in Patients with Uterine Cervical Cancer Treated by Radiation Therapy: a Preliminary Report. Annals of Nuclear Medicine, 2003; 17(7): 613-617  (SCI)

16.     Acupuncture to Alleviate Radiotherapy-Induced Xerostomia：A Preliminary Report. Mid Taiwan J Med, 2003; 8:268-73

17.     The Adverse Effect Of Treatment Prolongation In Cervical Cancer By High dose-rate Intracavitary Brachytherapy.

Radiotherapy & Oncology, 2003; 67(1), 69-76  (SCI)

18.     High dose-rate Brachytherapy For Elderly Patients with Uterine Cervical Cancer.

Jpn J Clin Oncol, 2003; 33(5), 221-228  (SCI)

19.     Postoperative radiotherapy for patients with invasive cervical cancer following treatment            with simple hysterectomy.

Jpn J Clin Oncol, 2003; 33(9), 477-481  (SCI)

20.     Detection of Cervical Lymph Node Metastases in Nasopharyngeal Carcinomas: Comparison with Technetium-99 Tetrofosmin Single Photon Emission Computed Tomography and with Magnetic Resonance Imaging.

Anticancer Research, 2003; 23:719-722  (SCI)

21.   Early stage cervical cancer with negative pelvic lymph nodes: Pattern of failure and complication following radical hysterectomy and adjuvant radiotherapy. European J of Gynecological Oncology, 2004; 21(1): 81-86  (SCI)

22.     Palliation of recurrent esophageal cancer after definite radiotherapy with intraluminal brachytherapy －A preliminary report.

Jpn Soc Ther Radiol Oncol, 2004; 16, 41-46  (SCI)

23.     Comparative study of reference points by dosimetric analysis for late complications after uniform external radiotherapy and high-dose-rate brachytherapy for cervical cancer.

Int. J. Radiation Oncology Biol. Phys., 2004; 60(2), 663-671  (SCI)

24.     Radiation injury to intestine following hysterectomy and adjuvant radiotherapy for cervical cancer.

Gynecologic Oncology, 2004; 95:208-214  (SCI)

25.     The implication of geometrical sparing factor of reference points for late complications following uniform external radiotherapy and high-dose-rate brachytherapy for cervical cancer .

Jpn J Clin Oncol, 2005; 17:17-24  (SCI)

26.     Outcome of salvage irradiation for breast cancer patients with locoregional recurrence. Therapeutic Radiology and Oncology, 2005; 12(2), 83-91

27.     Intensity-Modulated Radiotherapy Versus 3-D Tangential Therapy in The Treatment of Left Breast Cancer: A Comparative Planning Study.

Therapeutic Radiology and Oncology, 2005; 12(4), 267-275

28.     Comparative Dosimetric Study of Two Strategies of Intensity-Modulated Radiotherapy in Nasopharyngeal Cancer.

Medical Dosimetry, 2005; 30(4), 219-227  (SCI)

29.     Value of Computed Tomography-Based Tumor Volume as a Predictor of Outcomes in Hypopharyngeal Cancer After Treatment With Definitive Radiotherapy

Laryngoscope, 2006; 116, 2012-2017  (SCI)

30.     Concurrent Weekly Cisplatin Plus External Beam Radiotherapy And High-Dose Rate Brachytherapy For Advanced Cervical Cancer: A Control Cohort Comparason With Radiation Alone On Treatment Outcome And Complications

Int. J. Radiation Oncology Biol. Phys, 2006; 66 (5), 1370-1377.  (SCI)

31.     Survival outcome by early chemoradiation therapy salvage or early surgical salvage for the treatment of hypopharyngeal cancer.

Otolarygology-Head and Neck Surgery 2007;137,711-716 (SCI).

32.     Treatment Results of Hypopharyngeal Cancer based on Definitive Radiotherapy.

Therapeutic Radiology and Oncology 2007;14(2),63-73.

33.     Surface Dose Measurement in Intensity Modulated Radiotherapy.

Therapeutic Radiology and Oncology 2007;14(2),113-121.

34.     Hypopharyngeal Cancer Treatment Based on Definitive Radiotherapy: Who is Suitable for Laryngeal Preservation?

Journal of Laryngology and Otology 2008;122:506-512. (SCI).

35.     Risk Stratification for Failures in Patients with Advanced Cervical Cancer After Concurrent Chemoradiotherapy: Another feasible Strategy to Optimize Treatment Result.

Clin Oncol 2008;20 : 683-690 (SCI).

36.     Clinical Implications of Elevated Pretreatment Carcinoembryonic Antigen in Patients with Advanced Squamous Cell Carcinoma of the Uterine Cervix.

Tumor Biology 2008;29:255-261 (SCI)

37.     The Outcome and Prognostic Factors in Patients with Aspiration Pneumonia during Concurrent Chemoradiotherapy for Head and Neck Cancer.

European J Cancer Care 2009 (SCI in press).

38.     Prognostic Impact of Tumor Volume in Patients with Stage III-IVA Hypopharyngeal Cancer without Bulky lymph Nodes Treated with Definitive Concurrent Chemoradiotherapy.

Head Neck Journal 2009 (SCI in press).

39.     Geometrical Sparing Factors for the Rectum and Bladder in the Prediction

of Grade 2 and higher Complications Following High-Dose-Rate

Brachytherapy for Cervical Cancer

Int J Rad Oncol Biol Phys 2009 (SCI in press)

醫學會論文報告

l         The analysis of radiation injury to intestine following the treatment of cervical cancer by hysterectomy and adjuvant radiotherapy

2004,第9屆台灣癌症聯合醫學學術年會

l         Outcome of salvage irradiation for breast cancer with locoregional recurrence

2004,中華民國放射線醫學會第25屆第1次會員大會暨第53次學術研討會

l         Comparative dosimetric study of two strategies of intensity-modulated radiotherapy in nasopharyngeal patients

2005,第十屆台灣癌症聯合學術年會

l         Intensity-modulated Radiotherapy versus 3-D Conformal Therapy in the Treatment of Left breast Cander: A Comparative Planning Study

2005,第十屆台灣癌症聯合學術年會

l         Concurrent Weekly Cisplatin and Radiotherapy for Advanced Cervical Cancer:A Preliminary Report on Treatment Outcome and Complication

2006,第十一屆台灣癌症聯合學術年會

l         Treatment Results of Laryngeal Preservation Radiotherapy in Hypopharyngeal Cancer

    2006,第十一屆台灣癌症聯合學術年會

l         Buildup Region Measurements for High Energy Photon Beams

2006,中華民國放射線醫學會

l         Value of Computed Tomography Based Tumor Volume as a Predictor of Outcome in Hypopharyngeal Cancer

2006,中華民國放射線醫學會