CellNetOptimizer (CellNOpt, also known as CNO) is a toolbox for creating logic-based models of signal transduction networks, and training them agains high-throughput biochemical data using various logic formalisms.

CellNOpt is free to download  as a Bioconductor package in R at http://www.bioconductor.org/packages/devel/bioc/html/CellNOptR.html and as a MATLAB toolbox under the Creative Commons Attribution-No Derivative Works 3.0 United States License  - click on the arrow at the bottom right of this page to download it.