Go to Medical Biophysics Group Homepage Rommel G. Bacabac, SVD, PhD
Birth: June 29, 1969 Birth place: Manila, Philippines Nationality: Filipino Email: rgbacabac@gmail.com
Current Affiliation: 2010- Medical BioPhysics Group (leader) Department of Physics University of San Carlos Nasipit, Talamban Cebu City, Cebu, Philippines
Citations = 207 Publications: Peer-reviewed Journals: 1. Bacabac, R. G., T. H. Smit, R. M. Heethaar, J. J. van Loon, M. J. Pourquie, F. T. Nieuwstadt and J. Klein-Nulend, Characteristics of the Parallel-Plate Flow Chamber for Mechanical Stimulation of Bone Cells under Microgravity, J Gravit Physiol, 9, P181-182, 2002. 2. Klein-Nulend, J., R. G. Bacabac, J. P. Veldhuijzen and J. J. Van Loon, Microgravity and Bone Cell Mechanosensitivity, Adv Space Res, 32, 1551-1559, 2003. 3. Klein-Nulend, J., Bacabac R.G., van Loon J., Veldhuijzen P. Botverlies Door Gewichtsloosheid: Raakvlakken Met Osteoporose Journaal. 2003. 4. Bacabac, R. G., T. H. Smit, M. G. Mullender, S. J. Dijcks, J. J. Van Loon and J. Klein-Nulend, Nitric Oxide Production by Bone Cells Is Fluid Shear Stress Rate Dependent, Biochem Biophys Res Commun, 315, 823-829, 2004. 5. Bacabac, R. G., T. H. Smit, S. C. Cowin, J. J. Van Loon, F. T. Nieuwstadt, R. Heethaar and J. Klein-Nulend, Dynamic Shear Stress in Parallel-Plate Flow Chambers, J Biomech, 38, 159-167, 2005. 6. Bacabac, R. G., T. H. Smit, M. G. Mullender, J. J. Van Loon and J. Klein-Nulend, Initial Stress-Kick Is Required for Fluid Shear Stress-Induced Rate Dependent Activation of Bone Cells, Ann Biomed Eng, 33, 104-110, 2005. 7. Klein-Nulend J, Bacabac RG, Vatsa A, Tan SD, Smit ThH, Van Loon JJWA: Modulation of gene expression in bone cells during strain-adapted bone remodelling. J Gravitational Physiol 12:P225-P228, 2005. 8. Klein-Nulend J, Bacabac RG, Mullender MG: Mechanobiology of bone tissue. Mecanobiologie du tissu osseux. Pathologie Biologie 53:576-580, 2005. 9. Klein-Nulend J, Vatsa A, Bacabac RG, Tan SD, Smit ThH: The role of osteocytes in bone mechanotransduction. Current Opinion in Orthopaedics 16:316-324, 2005. 10. Klein-Nulend J, Bacabac RG, van Loon JJWA: Botverlies door gewichtloosheid: raakvlakken met osteoporose. Ned Tijdschr Calcium Botstofw 8:62-65, 2005. 11. Bacabac RG, Van Loon JJWA, de Blieck-Hogervorst JMA, Semeins CM, Zandieh-Doulabi B, Helder MN, Smit TH, Klein-Nulend J: Microgravity and bone cell mechanosensitivity: FLOW Experiment during the DELTA mission. Microgravity Science and Technology, 19(5-6): 133-137, 2007. 12. Bacabac, R. G., T. H. Smit, J. J. Van Loon, B. Z. Doulabi, M. Helder and J. Klein-Nulend, Bone Cell Responses to High-Frequency Vibration Stress: Does the Nucleus Oscillate within the Cytoplasm?, FASEB J, 20, 858-864, 2006. 13. Mullender, M. G., S. J. Dijcks, R. G. Bacabac, C. M. Semeins, J. J. Van Loon and J. Klein-Nulend, Release of Nitric Oxide, but Not Prostaglandin E2, by Bone Cells Depends on Fluid Flow Frequency, J Orthop Res, 24, 1170-1177, 2006. 14. Bacabac RG, Mizuno D, Vatsa A, Schmidt CF, MacKintosh FC, Van Loon JJWA, Klein-Nulend J, Smit TH: Round versus flat: bone cell morphology, elasticity, and mechanosensing. J Biomech 41:1590-1598, 2008 (Perren Award winning paper). 15. Mizuno, D., R. Bacabac, C. Tardin, D. Head and C. F. Schmidt, High-Resolution Probing of Cellular Force Transmission, Phys Rev Lett, 102, 168102, 2009. 16. Bacabac, R. G., J. J. Van Loon, T. H. Smit and J. Klein-Nulend, Noise Enhances the Rapid Nitric Oxide Production by Bone Cells in Response to Fluid Shear Stress, Technol Health Care, 17, 57-65, 2009. 17. Bakker, A. D., V. C. Silva, R. Krishnan, R. G. Bacabac, M. E. Blaauboer, Y. C. Lin, R. A. Marcantonio, J. A. Cirelli and J. Klein-Nulend, Tumor Necrosis Factor Alpha and Interleukin-1beta Modulate Calcium and Nitric Oxide Signaling in Mechanically Stimulated Osteocytes, Arthritis Rheum, 60, 3336-3345, 2009. 18. Piechoka, I. K., R. G. Bacabac, M. Potters, F. C. MacKintosh and G. H. Koenderink, Structural Hierarchy Governs Fibrin Gel Mechanics, Biophysical Journal, 98(10), 2281-2289, 2010. 19. Bacabac RG, Van Loon JJWA, Stress Response by Bone Cells and Implications on Microgravity Environment, Clinical Reviews in Bone and Mineral Metabolism, 8(4), 179-188, 2011. Scientific Magazine/Newsletter: 20. Bacabac RG, Van Loon JJWA, Klein-Nulend J: Response of bone cells to high-frequency, low-amplitude translational vibration stress. European Low Gravity Research Association Newsletter, #5, December, 2006. 21. Klein-Nulend J, Bacabac RG, Van Loon JJWA: Op weg naar een onderzoek naar de mechanogevoeligheid van botcellen in de ruimte. Ned Tijdschr Ca Botstofw 5:66-70, 2007. 22. Bacabac RG, Smit TH, Van Loon JJWA, Klein-Nulend J: De reacties van botcellen op vibratie. Ned Tijdschr Ca Botstofw 5:91-93, 2007. 23. Bacabac RG, van Loon JJWA, Klein-Nulend J: Bone Loss in space – Our sensitive skeleton. Scientific American, Special Issue “Looking up: Europe’s quiet revolution in microgravity research”. A custom publication produced in collaboration with Space Channel on behalf of the European Space Agency. 2008. 24. Bacabac RG, van Loon JJWA, Klein-Nulend J: Bone Loss in space – Our sensitive skeleton. GERMAN VERSION Scientific American, Special Issue “Looking up: Europe’s quiet revolution in microgravity research”. A custom publication produced in collaboration with Space Channel on behalf of the European Space Agency. 2010. Erratum publication: 25. Bacabac RG, Mizuno D, Vatsa A, Schmidt CF, MacKintosh FC, Van Loon JJWA, Klein-Nulend J, Smit TH: Erratum to “Round versus flat: bone cell morphology, elasticity, and mechanosensing”. J Biomech 41(12), 2786, 2008. International Conference Proceedings: 1. Klein-Nulend J, Vatsa A, Bacabac RG, Tan SD, Smit TH: Cell biology of mechano-adaptive bone remodeling. In Biomaterials in Orthopaedic Practice, ABIOMED lecture notes 5, Workshop on Biomaterials, BMAT 2005, pp 31-48, Editors T. Lekszycki, P. Maldyk, Publ IPPT-Pan, Institute of Fundamental Technological Research, Warsaw, Poland, 2005. 2. Klein-Nulend J, Bacabac RG, Vatsa A, Tan SD, Smit TH: Cell Bioloy for Mechano-Adaptive Bone Remodeling. In Biological mechanisms of tooth eruption, resorption, and movement. Proceedings of the Eighth International Conference Held at Hilton Phuket Arcadia Resort & Spa, Phuket, Thailand, Nov 7-10, 2005 (editors Ze’ev Davidovitch, James Mah, Sasithorn Suthanarak). Published by University of Southern California, School of Dentistry, 2006, Printed by O.S. Printing House Co, Ltd, Bangkok, Thailand. pp 159 - 168, 2006. 3. Bacabac RG, Mizuno D, Schmidt CF, MacKintosh FC, Van Loon JJWA, Smit TH, Klein-Nulend J, Microrheology and Force Traction of Mechanosensitive Bone Cells, J Biomech, 39 (Supp1), S231-S232, 2006. 4. Bacabac RG, Van Loon JJWA, Smit TH, Klein-Nulend J, Noise-enhanced Response of Bone Cells to Fluid Shear Stress, J Biomech 39 (Supp1), S457, 2006. 5. Bacabac RG, Piechocka I, Koenderink G, Single Cell Traction in an In Vitro Tissue Model, Proceedings of the II International Conference on Tissue Engineering, Lisbon, Portugal, 2011. 6. Bacabac RG, Ayade H, Villaruz LGM, Bernido C, Bernido-Carpio MV, Otadoy R, Biorheology: Extracting Mechanical Properties of Single Biopolymers and Networks Beyond Thermal Conditions, Proceedings of the II International Conference on Tissue Engineering, Lisbon, Portugal, 2011. 7. Bacabac RG, Van Loon JJWA, Stress Response by Bone Cells and Implications on Microgravity Environment, Proceedings of the II International Conference on Tissue Engineering, Lisbon, Portugal, 2011. Manuscript Drafts: 1. Bacabac, R.G., K. Jansen, I. Piechocka, G.H. Koenderink. Contractile Cells Actively Stiffen Matrix. (manuscript draft; 2011). 2. Bacabac, R.G., A. Bakker, D. Schooneman, J. Klein-Nulend. Dependency of the NO and PGE2 Response of Mechanically-Loaded Osteocytes on the Cytoskeleton. (manuscript draft; 2011). 3. Bacabac, R.G., R. Otadoy, H. Ayade, L.G.M. Villaruz, M.V. Carpio-Bernido, C. Bernido. Biorheology: Extracting Mechanical Properties of Single Biopolymers and Networks Beyond Thermal Conditions. (manuscript draft; 2011). Book chapter/Report: 1. Bacabac RG. Microrheology of mechanosensitive bone cells. ASCS book chapter (internal report), 2007. 2. Bacabac RG, Van Loon JJWA, Klein-Nulend J: Microgravity and bone cell mechanosensitivity. In: Biology in space and life on earth. Effects of spaceflight on biological systems (editor Brinckmann E). Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany, pp 157-178, 2007. 3. Bacabac, RG, Mizuno D., Koenderink G.H. Mechanical properties of living cells: on mechanosensing and microgravity. In: Cell Mechanochemistry (ed. Monica Monici and Jack Van Loon). Kerala/India: Transworld Research Network, pp 23-34, 2010. 4. Bacabac, RG, Van Loon JJWA. Stress Response by Bone Cells and Implications on Microgravity Environment, Clinical Reviews on Bone Mineral Metabolism (DOI 10.1007/s12018-011-9082-x). Invited Lectures: 1. Bacabac RG, Smit TH, Van Loon JJWA, Klein-Nulend, J: “Microgravity and Bone Cell Mechanosensitivity”, Dept Mechanical Engineering, University of Osaka, 2002. 2. Bacabac RG, Smit TH, Van Loon JJWA, Klein-Nulend, J: “Microgravity and Bone Cell Mechanosensitivity”, Dept Mechanical Engineering, Polytechnic University of Hong Kong, 2002. 3. Bacabac RG: “Rheology of Mechanosensitive Bone Cells”, IIASA-Kyoto University, The Third Joint International Seminar on Applied Analysis and Synthesis of Complex Systems, International Institute for Applied Systems Analysis, Laxenburg, Austria, 2005. 4. Bacabac RG: “Round vs. Flat: Bone Cell Morphology, Elasticity, and Mechanosensing”, Mechanics of Adaptive Materials and Structures Lab., Dept Mechanical Engineering and Science, Kyoto University, Japan, 2006. 5. Bacabac RG: “Round vs. Flat: Bone Cell Morphology, Elasticity, and Mechanosensing”, Dept Orthodontics and Dentofacial Orthopedics, Grad Sch Med Dent Pharmaceutical Sci, Okayama University, Japan, 2006. 6. Bacabac RG: “Physics of Small Things (mesoscopic mechanics of non-equilibrium phenomena)”. College of Arts and Sciences Academic Forum, University of San Carlos, Nasipit, Talamban, Cebu City 6000, Philippines. 7. Bacabac RG: “Mesoscopic Physics”, Philosophy and Religious Education department, University of San Carlos, Nasipit, Talamban, Cebu City 6000, Philippines. 8. Bacabac RG: “Mesoscopic BioMechanics: from BioPolymers to Living Systems”, Enzyme and Environmental Biotechnology Lab., Graduate Program in Bioengineering, Seoul National University, South Korea, 2010.
Postdoctoral Research: 2007-2010 Project: Cell-Gel complexes FOM-Institute for Atomic and Molecular Physics (AMOLF), Amsterdam The Netherlands 2005-2007 Project: “Bone cell mechanosensitivity and microgravity” Dept Oral Cell Biology,
ACTA-Universiteit van Amsterdam & Vrije Universiteit, Education: Science and Mathematics: 2006 Vrije Universiteit Amsterdam, The Netherlands PhD degree cum laude Thesis: “Microgravity and Bone Cell Mechanosensitivity” 2001 Vrije Universiteit Amsterdam, The Netherlands MS Experimental Physics 1998 University of San Carlos (USC), Cebu City, Philippines BS Physics 1992-1993 University of San Carlos (USC), Cebu City, Philippines (summer) Units for MS Mathematics 1992-1993 Ateneo de Davao University, Davao City, Philippines Advanced Mathematics courses Philosophy and Theology: 1993-1994 Ateneo de Davao University, Davao City, Philippines Units for MA in Religious education 1991-1993 Regional Major Seminary, Davao City, Philippines Theological studies 1990 Christ the King Mission Seminary, Quezon City, Philippines AB Classical Philosophy magna cum laude 1986 Christ the King Mission Seminary, Quezon City, Philippines Secondary education (High School, valedictorian) Academic honors/Awards: 1. Cum Laude PhD degree (2006) 2. S.M. Perren Research Award (2006) “Round versus Flat: Bone Cell Morphology, Elasticity, and Mechanosensing” (Most prestigious award of the European Society of Biomechanics) presented at: 5th World Congress of Biomechanics (Munich, Germany) 3. Experimental Award of Excellence (2003) “Fluid Shear Stress-Induced Activation of Bone Cells is Rate Dependent” presented at: 5th International Bone Fluid Flow Workshop (Ohio, USA) 4. Magna cum Laude AB Classical Philosophy (1990) 5. Valedictorian Secondary education (High School, 1986) Grants: 1. PhD Researcher (2001-2005) Funded by: Space Research Organization of the Netherlands (SRON) “Microgravity and Bone Cell Mechanosensitivity” (“flowspace”) 2. S.M. Perren Research Award (2006) Round versus Flat: Bone Cell Morphology, Elasticity, and Mechanosensing” AO Foundation, Davos, Switzerland 10,000.00 Swiss Francs honorarium 3. Primary Investigator (2002) Funded by the Physics Development Project PDP grant # PHL-146 “Development of an optical tweezer setup”: Funds were received by RG Bacabac via the Center for International Cooperation (CIS) in the Netherlands, to assemble and build a double-laser optical tweezer setup in an inverted microscope system for research on the microrheology of mechanosensitive cells, and applications on soft matter physics. This project was carried out in close collaboration of the Dept Physics of Complex Systems, Vrije Universiteit and the Dept Oral Cell Biology, ACTA-Universiteit van Amsterdam and Vrije Universiteit. 4. Travel grant as “Experimental Award of Excellence” recipient (2003) “Fluid Shear Stress-Induced Activation of Bone Cells is Rate Dependent” presented at: 5th International Bone Fluid Flow Workshop (Ohio, USA) 5. Main Researcher (2002-2004) Funded by: Space Research Organization of the Netherlands (SRON) “FLOW”- Soyuz flight experiment to the International Space Station (ISS) 6. Postdoctoral Researcher (2005-2007) Funded by: Space Research Organization of the Netherlands (SRON) "FLOW2”- preparations for a Soyuz flight experiment to the ISS 7. Travel Grant (invited speaker) (2005) Funded by: The 21st Century Center of Excellence (COE) Program “Rheology of Mechanosensitive Bone Cells”, IIASA-Kyoto University, The Third Joint International Seminar on Applied Analysis and Synthesis of Complex Systems, International Institute for Applied Systems Analysis, Laxenburg, Austria 8. Research Visit (2006) Funded by: The 21st Century Center of Excellence (COE) Program “Imaging Bone Cell Responses to Mechanical Stress” Mechanics of Adaptive Materials and Structures Lab., Dept Mechanical Engineering and Science, Kyoto University, Japan 9.Travel Grant (invited speaker) (2006) “Round vs. Flat: Bone Cell Morphology, Elasticity, and Mechanosensing”, Dept Orthodontics and Dentofacial Orthopedics, Grad Sch Med Dent Pharmaceutical Sci, Okayama University, Japan 10. Postdoctoral Researcher (2007-2010) Funded by: Fundamental Research on Matter (FOM) “Physics of Cell-Gel Complex” Biological Soft Matter group FOM-Institute for Atomic and Molecular Physics Amsterdam, The Netherlands 11. Co-Investigator (2011-2015) Funded by: Space Research Organization of the Netherlands (SRON) “Bone Cell Mechanics under Altered Gravity” 12. Travel Grant (invited speaker) (2010) “Mesoscopic BioMechanics: BioPolymers to Living Systems”, Enzyme and Environmental Biotechnology Lab., Graduate Program in Bioengineering, Seoul National University, South Korea Research Visit 1. Mechanics of Adaptive Materials and Structures Lab. (October-November, 2006) Department of Mechanical Engineering and Science Graduate School of Engineering, Kyoto University Funding: The 21st Century COE Program Center of Excellence for Research and Education on Complex Functional Mechanical Systems 2. Summer research visits (3x 3-4weeks, 2008-2010) Dept Molecular and Cellular Biophysics Biophysics III. Physical Institute- Oscillation Physics Georg August University Gottingen, Germany Professional societies: 1. American Society for Cell Biology 2. European Society for Biomechanics 3. American Society for Gravitational and Space Biology 4. European Low Gravity Research Association 5. Samahang Pisika ng Pilipinas 6. The Dutch Society for Calcium and Bone Metabolism Served as Scientific Committee Ninth Bone Fluid Flow Workshop- Bone Fluid Flow, Adaptation, and Regeneration Vrije Universiteit, Amsterdam, The Netherlands, May 22-23, 2008. Supervision of the following: 1. Dijcks S, student at Technical University Eindhoven: The effect of mechanical loading on MC3T3-E1 bone cells is modulated by flow characteristics, Dept Oral Cell Biology, ACTA-Vrije Universiteit, Amsterdam, The Netherlands. 2002. 2. Violanda R, Physics lecturer at the University of San Carlos, Cebu City, Philippines: Development of an optical tweezer setup, Physics of Complex Systems, Dept Physics, Vrije Universiteit, Amsterdam, The Netherlands. 2003-2004. 3. de Blieck-Hogervorst J.M.A., research assistant at the Vrije Universiteit Amsterdam: FLOW-Dutch Soyuz Mission. 2003-2007. 4. Schooneman DPM, student internship at the Dept Oral Biology, ACTA-Vrije Universiteit, Amsterdam, The Netherlands. 2006-2007. 5. Gicale DM and Bitanga EMM, BS Physics Thesis Adviser: “Modeling the Interaction Potential between the Probe and Living Mammalian cells in Nano-indentation Rheology”, Medical Biophysics group, Dept Physics, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines. 2010-2011. 6. Besinga JAB and Graciosa JCA, BS Physics degree Thesis Adviser: “Non-equilibrium Mechanics of Active Bacterial Suspensions”, Medical Biophysics group, Dept Physics, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines. 2010-2011. 7. Villaruz, LGM, MS Physics Thesis Adviser: “Measurement of Local Viscoelasticity in Living Mammalian Cells by Optical Tweezers”, Medical Biophysics group, Dept Physics, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines. 2010-2011. 8. Ayade H, MS Physics Thesis Adviser: “Dynamical Response of a Network of Uncrosslinked Polymers”, Medical Biophysics group, Dept Physics, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines. 2010-2011. 9. Licup A. MS Physics degree holder, group member, Medical Biophysics group, Dept Physics, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines. 2010-2011. Collaborations: 1. Dr.ir. Smit, Th H, Dept of Physics and Medical Technology, VUMC, Amsterdam, NL: fluid flow apparatus; osteocytes; bone remodeling and biomechanics. 2. Prof.dr. Heethaar R, Dept of Physics and Medical Technology, VUMC, Amsterdam, NL: fluid flow apparatus; osteocytes and bone remodelling. 3. Prof.dr. Schmidt CF, Vrije Universiteit, Dept Biophysics and Complex Systems, Amsterdam, NL. 4. Prof.dr. MacKintosh FC, Vrije Universiteit, Dept Theoretical Physics, Amsterdam, NL. 5. Prof.dr.ir. Frans Nieuwstadt, Technical University of Delft, Delft, NL: biofluid dynamics, computational fluid dynamics 6. Dr.ir. Mathieu Pourquie, Technical University of Delft, Delft, NL: biofluid dynamics, computational fluid dynamics 7. Prof.dr.ir. Cowin SC, CUNY, New York, NY, USA: Parallel-plate flow chambers; bone biomechanics 8. Dr. Marco M. Helder, Dr. Behrouz Zandieh Doulabi, Dept Oral Cell Biology, Vrije Universiteit-ACTA, Amsterdam, The Netherlands 9. Dr. Behrouz Zandieh Doulabi, Dept Oral Cell Biology, Vrije Universiteit-ACTA, Amsterdam, The Netherlands 10. Prof. Taiji Adachi, Dr. Mototsugu Tanaka, Prof. Hojo, Mechanics of Adaptive Materials and Structures Lab., Department of Mechanical Engineering and Science, Graduate School of Engineering, Kyoto University, Kyoto, Japan 11. Dr. Hiroshi Kamioka, Dept Orthodontics and Dentofacial Orthopedics, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan. 12. Dr. Daisuke Mizuno, Institute for Advanced Study, Kyushu University, Japan. 13. Dr. Christopher Bernido, Central Visayan Instittue foundation, Jagna, Bohol, Philippines. 14. Dr. Ma. Victoria Carpio-Bernido, Central Visayan Instittue foundation, Jagna, Bohol, Philippines. 15. Dr. Roland Otadoy, Geophysics group, Dept Physics, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines 16. Dr. Frances Edillo, Dept Biology, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines 17. Dr. Paul John L. Geraldino, Dept Biology, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines 18. Dr. Filipina B. Sotto, Dept Biology, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines 19. Dr. Josephine M. Castañares, Dept Chemistry, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines 20. Dr. Evelyn B. Taboada, Dept Chemical Engineering, University of San Carlos, Nasipit, Talamban, Cebu City, Philippines Abstracts (presented on scientific meetings): 1. Bacabac, RG, Smit, TH, Van Loon, JJWA, Pourquie, MJMB, Nieuwstadt, FTM, Klein-Nulend J: Microgravity and bone cell mechanosensitivity: rheological characterization of the parallel-plate flow chamber. Proceedings 3rd NL-Gravity and Astrobiology Symposium, 2001: http://www.desc.med.vu.nl/frames.htm. (oral presentation) 2. Bacabac RG, Smit TH, Van Loon JJWA, Pourquie MJMB, Nieuwstadt FTM, Heethaar R, Klein-Nulend J: Miniaturizing the Parallel Plate Chamber for Flow Stimulation of Bone Cells in Microgravity. Proc Life In Space For Life On Earth, 8th European Symposium on Life Sciences, 23rd Annual International Gravitational Physiology Meeting, Stockholm, Sweden, p 102, 2002. (oral presentation) 3. Bacabac RG, Smit TH, Heethaar RM, Van Loon JJWA, Pourquie MJMB, Nieuwstadt FTM, Klein-Nulend J: Design of a parallel-plate flow chamber for dynamic fluid flow stimulation of bone cells under microgravity. Proc Advanced School and Workshop on “Bone Mechanics – Mathematical and Mechanical Models for Analysis and Synthesis”, Lisbon, Portugal, 2002. (oral presentation) 4. Bacabac RG, Smit TH, Heethaar RM, Van Loon JJWA, Pourquie MJMB, Nieuwstadt FTM, Klein-Nulend J: Proc Parallel-plate flow chamber characterization for mechanical stimulation of bone cells in microgravity. Fourth bone fluid flow meeting—bone fluid flow, adaptation, and regeneration, 6-7, May, 2002, Amsterdam, NL, abstract #31. http://www.med.vu.nl/flow/abstracts.htm. (poster) 5. Bacabac RG, Smit TH, Heethaar RM, Van Loon JJWA, Pourquie MJMB, Nieuwstadt FTM, Klein-Nulend J: Parallel-plate flow chamber characterization for mechanical stimulation of bone cells under microgravity. Proc Biomechanics Symposium, 2002. (oral presentation) 6. Bacabac RG, Van Loon JJWA, Dijcks SJ, Smit TH, Klein-Nulend J: Microgravity and bone cell mechanosensitivity- bone cell activation is fluid shear rate dependent. The bi-annual ALW/FOM/VvBF&BT meeting on Molecular and Cellular Biophysics, 2002. (poster) 7. Klein-Nulend, J, Bacabac RG, Veldhuijzen JP, Van Loon JJWA: Microgravity and bone cell mechanosensitivity. Proc 34th Cospar Scientific Assembly and the Second World Space Congress, Houston, TX, USA, 2002. abstract no F1.4-000-02, 2002. (oral presentation) 8. Dijcks SJ, Mullender MG, Bacabac RG, Klein-Nulend J: The effect of mechanical loading by fluid flow on MC3T3-E1 bone cells is modulated by flow characteristics. Proc 12th Annual Meeting of the Dutch Society for Calcium and Bone Metabolism, abstract p 14, 2002. (oral presentation) 9. Van Loon JJWA, Bacabac RG, Dijcks SJ, Mullender M, Smit TH, Klein-Nulend J: Characterization of the parallel-plate flow chamber for mechanical stimulation of bone cells under microgravity. Cellular response to fluid flow by NO production is fluid shear rate dependent. 18th American Society for Gravitational and Space Biology Annual meeting, Cape Canaveral, FL, USA, 2002. (oral presentation) 10. Bacabac RG, Dijcks SJ, Mullender MG, Smit TH, Van Loon JJWA, Klein-Nulend J: Rapid nitric oxide production by fluid flow treated bone cells is fluid shear rate dependent. Transactions of the 49th Annual Meeting, Orthopaedic Research Society, Vol 28: abstract no 0128, 2003. (oral presentation) 11. Bacabac RG, Smit TH, Dijcks S, van Loon JJWA, Klein-Nulend J: Microgravity and bone cell mechanosensitivity – fluid shear stress-induced nitric oxide production by bone cells is rate dependent. Proc 24th Annual International Gravitational Physiology Meeting, 4-9 May, 2003, Santa Monica, CA, USA. (oral presentation) 12. Bacabac RG, Smit TH, Dijcks SJ, Van Loon JJWA, Klein-Nulend J: Microgravity and Bone Cell Mechanosensitivity--Rapid nitric oxide production by bone cells is fluid shear rate dependent. European Low Gravity Research Association (ELGRA) Biennial Meeting, 2003. (oral presentation) 13. Bacabac RG, Smit TH, Dijcks S, Van Loon JJWA, Klein-Nulend J: Microgravity and bone cell mechanosensitivity – bone cell activation is fluid shear rate dependent. Proc Biology and Physics at Interfaces, From SingleMolecules to Cells, 21-23 May 2003, Jülich, Germany, abstract # P32 (poster) 14. Vatsa A, Bacabac RG, Dordai DV, Smit TH, Schmidt CF, MacKintosh FC, Sgalari G, Klein-Nulend J: Application of DAR-4M AM (a rhodamine chromophore) in bio-imaging of intracellular Nitric Oxide production in response to mechanical stimulation in MC3T3-E1 osteoblastic cells. Proc Biology and Physics at Interfaces, From SingleMolecules to Cells, 21-23 May 2003, Jülich, Germany, abstract # P39 (poster) 15. Mullender M, Dijcks SJ, Bacabac RG, Semeins CM, Van Loon JJWA, Klein-Nulend J: Nitric oxide but not prostaglandin E2 production of osteoblastic cells is shear stress rate dependent. Proc 13th Annual Meeting of the Dutch Society for Calcium and Bone Metabolism, abstract p 36, 2003. (oral presentation) 16. Bacabac RG, Dijcks SJ, Mullender MG, Smit TH, Van Loon JJWA, Klein-Nulend J: Fluid shear stress-induced activation of bone cells is rate dependent. Proc 13th Annual Meeting of the Dutch Society for Calcium and Bone Metabolism, abstract p 27, 2003. 17. Bacabac RG, Dijcks SJ, Mullender MG, Smit TH, Van Loon JJWA, Klein-Nulend J: Fluid shear stress-induced activation of bone cells is rate dependent. 5th International Bone Fluid Flow Workshop, 2003. (oral presentation: “BFF Experimental Award of Excellence Abstract Presentation”). 18. Mullender M, Dijcks SJ, Bacabac RG, Semeins CM, Van Loon JJWA, Klein-Nulend J: Nitric oxide but not prostaglandin E2 production of MC3T3-E1 osteoblastic cells is shear stress rate dependent. Transactions of the 50th Annual Meeting, Orthopaedic Research Society, Vol 29, abstract no 89, 2004. (poster) 19. Bacabac RG, Smit TH, Mullender MG, Dijcks SJ, Van Loon JJWA, Klein-Nulend J: Fluid shear stress-induced activation of bone cells is rate dependent and requires an initial stress kick. Transactions of the 50th Annual Meeting, Orthopaedic Research Society, Vol 29, abstract no 2004. (oral presentation) 20. Mullender M, Dijcks SJ, Bacabac RG, Semeins CM, Van Loon JJWA, Klein-Nulend J: Fluid shear rate modulates the release of nitric oxide, but not prostaglandin E2 production in MC3T3-E1 osteoblastic cells. ESB 2004. (oral presentation) 21. Bacabac RG, Smit TH, Van Loon JJWA, Klein-Nulend J: Microgravity and bone cell mechanosensitivity- Bone cell activation by vibration stress. 2004 American Society of Gravitational and Space Biology Meeting, Brooklyn, NY, USA, November 9-12, 2004. (poster) 22. Bacabac RG, Smit TH, Mullender MG, Van Loon JJWA, Klein-Nulend J: Initial stress-kick is required for fluid shear stress-induced activation of bone cells. ALW/FOM/VvBBMT-Meeting on Molecular and Cellular Biophysics, Lunteren, The Netherlands, September 27-28, 2004. (poster) 23. Bacabac RG, Van Loon JJWA, Smit TH, Klein-Nulend J: Noise-aided amplification of nitric oxide production by bone cells in response to fluid shear stress. 2004 Annual meeting of the dutch society for calcium and bone metabolism, October 28-29, 2004. (oral presentation) 24. Bacabac RG, Van Loon JJWA, Smit TH, Klein-Nulend J: Noise-aided amplification of nitric oxide production by bone cells in response to fluid shear stress. 2004 The 22nd Samahang Pisika ng Pilipinas Physics Congress, October 25-28, 2004. (oral presentation) 25. Bacabac RG, van Loon JJWA, de Blieck-Hogervorst JMA, Semeins CM, Tan D, Vatsa A, van Duin MA, Klein-Nulend J: Microgravity and bone cell mechanosensitivity (flow). Abstract submitted for publication in ESA bulletin. 26. Bacabac RG, Van Loon JJWA, Smit TH, Klein-Nulend J: Stochastic resonance in rapid bone cell response to fluid shear stress. 15th Annual meeting of the Dutch Society for Calcium and Bone Metabolism, Zeist, The Netherlands, October 27-28, 2005. (oral presentation) 27. Bacabac RG, Mizuno DS, Schmidt CF, MacKintosh FC, Smit TH, Van Loon JJWA, Klein-Nulend J: Microrheology, force traction, and stress fluctuation of mechanosensitive bone cells. 15th Annual meeting of the Dutch Society for Calcium and Bone Metabolism, Zeist, The Netherlands, October 27-28, 2005. (oral presentation) 28. Bacabac RG, Smit TH, Van Loon JJWA, Klein-Nulend J: Rapid nitric oxide production by bone cells in response to mechanical vibration, International Society of Gravitational Physiology (ISGP) Joint Life Science Conference Life in Space for Life on Earth, Cologne, Germany, June 26- July 1, 2005. 29. Bacabac RG, Mizuno DS, Smit TH, Van Loon JJWA, Schmidt CF, MacKintosh FC, Klein-Nulend J: Microrheology, force traction and stress fluctuations in mechanosensitive bone cells. Annual Dutch meeting on Molecular and Cellular Biophysics, Lunteren, The Netherlands, October 10-11, 2005. (oral presentation) 30. Bacabac RG, Smit TH, Van Loon JJWA, Klein-Nulend J: Nitric oxide production by bone cells in response to mechanical vibration. 2005 Transactions of the 51st Annual meeting of the Orthopaedic research society, 2005. (oral presentation) 31. Bacabac RG, Mizuno DS, Smit TH, Van Loon JJWA, MacKintosh FC, Schmidt CF, Klein-Nulend J: Novel application of two-particle microrheology for measuring the viscoelasticity and probing the mechano-activity of bone cells. 7th International Bone Fluid Flow Workshop Translational Bone Fluid Flow, New York City, NY, USA, September 20-21, 2005. (oral presentation) 32. Klein-Nulend J, Bacabac RG: Nitric oxide production by bone cells in response to mechanical vibration. Seventh International Bone Fluid Flow Workshop – Translational Bone Fluid Flow. Sept 20-21, 2005. 33. Klein-Nulend J, Vatsa A, Bacabac RG, Tan SD, van Loon JJWA, Smit ThH: Mechanosensing and mechanotransduction in bone cells. Proc ESB Thematic Workshop on Mechanobiology of Cells and Tissue Regeneration, 28-30 August 2005, Leuven, Belgium, abstract p. 76, 2005. 34. Bacabac RG, Mizuno DS, Schmidt CF, MacKintosh FC, Smit TH, Van Loon JJWA, Klein-Nulend J: 45th Annual Meeting of the American Society for Cell Biology, San Francisco, CA, USA, December 10-14, 2005. (poster) 35. Blaauboer ME, Bacabac RG, Vatsa A, Santos A, Semeins CM, Klein-Nulend J: Fluid flow dependent NO production in MLO-Y4 osteocyte-like cells is dependent on calcium signaling. Proc 16th Annual Meeting of the Dutch Society for Calcium and Bone Metabolism, abstract p. 24, 2006. 36. Bacabac RG, Smit TH, Van Loon JJWA, Klein-Nulend J: Noise-aided amplification of nitric oxide production by bone cells in response to fluid shear stress. 2006 Transactions of the 52nd Annual meeting of the Orthopaedic research society, 2006. (oral presentation) 37. Bacabac RG, Mizuno DS, Schmidt CF, MacKintosh FC, Smit TH, Van Loon JJWA, Klein-Nulend J: Characterizing the viscoelasticity and the external force fluctuation of mechanosensitive bone cells. 2006 Transactions of the 52nd Annual meeting of the Orthopaedic research society, 2006. (oral presentation) 38. Bacabac RG, Mizuno D, Vatsa A, Schmidt CF, MacKintosh FC, Van Loon JJWA, Klein-Nulend J, Smit ThH: Bone Cell Mechanosensitivity and Elasticity in Round and Flat Morphologies. Proceedings Tissue Engineering & Regenerative Medicine International Society European Chapter Meeting 2006, Rotterdam, NL, abstract no. 185, p 141, 2006. (oral presentation). 39. Bacabac RG, Van Loon JJWA, Smit ThH, Klein-Nulend J: Amplified Response of Bone Cells to Fluid Shear Stress Superposed with Noise. Proceedings Tissue Engineering & Regenerative Medicine International Society European Chapter Meeting 2006, Rotterdam, NL, abstract no. 192, p 147, 2006. (oral presentation). 40. Bacabac RG, Mizuno D, Schmidt CF, MacKintosh FC, Smit ThH, Van Loon JJWA, Klein-Nulend J: Viscoelastic Properties and Force Traction of Mechanosensitive Bone Cells under 3-Dimensional Morphological Configuration. Proceedings Tissue Engineering & Regenerative Medicine International Society European Chapter Meeting 2006, Rotterdam, NL, abstract no. 47, p 49, 2006. (oral presentation). 41. Bacabac RG, Mizuno D, Schmidt CF, MacKintosh FC, Smit ThH, Van Loon JJWA, Klein-Nulend J: Microrheology and Force Traction of Mechanosensitive Bone Cells. 5th World Congress of Biomechanics, Munich Germany, July 29- August 4, 2006. (oral presentation). 42. Bacabac RG, Van Loon JJWA, Smit ThH, Klein-Nulend J: Noise-Enhanced Response of Bone Cells to Fluid Shear Stress. 5th World Congress of Biomechanics, Munich Germany, July 29- August 4, 2006. (oral presentation, invited paper). 43. Bacabac RG, Mizuno D, Vatsa A, Schmidt CF, MacKintosh FC, Van Loon, JJWA, Klein-Nulend J, Smit ThH: Round Versus Flat: Bone Cell Morphology, Elasticity, and Mechanosensing. 5th World Congress of Biomechanics, Munich Germany, July 29- August 4, 2006. (winner: 2006 S.M. Perren Award, oral presentation). 44. Bacabac RG, Mizuno D, Schmidt CF, MacKintosh FC, Smit TH, Van Loon JJWA, Klein-Nulend J: Viscoelasticity and force traction of bone cells in 3-dimensional morphology. Calcif Tissue Int 80:abstract no P129-T, p s72, 2007 45. Bacabac RG, Mizuno D, Schmidt CF, MacKintosh FC, Van Loon JJWA, Klein-Nulend J, Smit TH: Mechanosensitivity and elasticity of bone cells under round and flat morphologies. Calcif Tissue Int 80:abstract no. P130-S, p s72, 2007 46. Bacabac RG, Van Loon JJWA, Smit TH, Klein-Nulend J: Enhanced response of bone cells to noisy fluid shear stress. Calcif Tissue Int 80:abstract no P131-M, 2007 47. Bacabac RG, Piechocka I, Duineveld S, Koenderink GH, Viscoelastic behaviour of 3D biomimetic gel-cell complexes, 4th Dutch Soft Matter Meeting at TU Eindhoven, April 10, 2008, (“soundbite” presentation). 48. Bacabac RG, Mizuno D, Schmidt CF, MacKintosh FC, Smit TH, Van Loon JJWA, Klein-Nulend J, Elasticity, mechanosensing and force traction by bone cells under varying morphologies. 52nd Annual Meeting and 16th International Biophysics Congress (IUPAB), Long Beach, California, USA 2008. (poster presentation). 49. Bacabac RG, Mizuno D, Schmidt CF, MacKintosh FC, Smit TH, Van Loon JJWA, Klein-Nulend J, Elasticity, mechanosensing and force traction by bone cells under varying morphologies. Frontiers in Microrheology Workshop, CNSI at UCLA, California, USA. 2008. (poster presentation). 50. Bacabac RG, Piechocka I, Duineveld S, Koenderink GH, Active Mechanical Behaviour of a Biomimetic Tissue Model, Annual Dutch Meeting on Molecular and Cellular Biophysics, 2008. (poster presentation). 51. Bacabac RG, Mizuno D, Schmidt CF, MacKintosh FC, Smit TH, Van Loon JJWA, Klein-Nulend J, Elasticity, mechanosensing and force traction by bone cells under varying morphologies. Physical Biology Circle Meeting, EMBL Heidelberg, January 17-18, 2008. 52. Bakker AD, da Silva VC, Krishnan R, Bacabac RG, Blaauboer ME, Lin Y-C, Marcantonio RAC, Cirelli JA, Klein-Nulend J: TNFa and IL-1b modulate calcium and nitric oxide signalling in mechanically stimulated osteocytes. Transactions of the 55th Annual Meeting, Orthopaedic Research Society, Vol 34:abstract # 83, 2009. 53. Bacabac RG, Piechocka I, MacKintosh FC, Koenderink GH, Active Mechanical Behaviour of a Biomimetic Tissue Model, 3rd European Meeting on Cell Mechanics, Physikzentrum, Bad Honnef, October 19-21, 2009. 54. Bacabac RG, Piechocka I, Koenderink GH, Cell Traction in a biomimetic tissue model, 6th World Congress on Biomechanics, Suntec Convention and Exhibition Centre, August 1-6, 2010 (oral presentation). 55. Nakamasu A, Bacabac RG, Schmidt CF, Mizuno D, Exploring Physical Calibration Mechanism for Cellular Mechano-sensing, 5th Pacific Rim Conference on Rheology (PRCR2010), August 1-6, 2010, Sapporo, Japan. 56. Mizuno D, Bacabac RG, Lautscham L, Head D, Schmidt CF, Exploring Physical Calibration Mechanism for Cell Mechano-sensing, SPIE Conference 7762 Optical Trapping and Optical Manipulation VII (August 1-5, 2010), San Diego, California, United States. 57. Kamioka H, Imai Y, Bakker AD, Bacabac RG, Yamashiro T, Klein-Nulend J, Microstructure of Osteocyte Cell Processes and Surrounding Bone Matrix Revealed by Ultra-high Voltage Electron Microscopy Tomography, Orthopaedic Research Society Annual Meeting, Long Beach, California, 2011 (oral presentation). 58. Bacabac RG, Piechocka I, Koenderink G, Single Cell Traction in an In Vitro Tissue Model, II International Conference on Tissue Engineering, Lisbon, Portugal, 2011 (oral presentation). 59. Bacabac RG, Ayade H, Villaruz LGM, Bernido C, Bernido-Carpio MV, Otadoy R, Biorheology: Extracting Mechanical Properties of Single Biopolymers and Networks Beyond Thermal Conditions, II International Conference on Tissue Engineering, Lisbon, Portugal, 2011 (oral presentation). 60. Bacabac RG, Van Loon JJWA, Stress Response by Bone Cells and Implications on Microgravity Environment, II International Conference on Tissue Engineering, Lisbon, Portugal, 2011 (oral presentation). 61. Villaruz LGM, Bitanga EMM, Carpio-Bernido MV, Bernido CC, Otadoy RE, Bacabac RG, Effect of Surface Adhesive Forces on Local Elasticity of Living Mammalian Cells, 31st Annual Meeting & Symposium (31APAMS): Science Engineering Education, Research and Innovation Toward National Development and Global Competitiveness, June 15-18, 2011, National Institute of Physics, National Science Complex, University of the Philippines, Diliman, Quezon City, Philippines (poster presentation) 62. Ayade HL, Licup AJ, Bernido CC, Carpio-Bernido MV, Otadoy RE, Bacabac RG, Elasticity of Single Biopolymers, 31st Annual Meeting & Symposium (31APAMS): Science Engineering Education, Research and Innovation Toward National Development and Global Competitiveness, June 15-18, 2011, National Institute of Physics, National Science Complex, University of the Philippines, Diliman, Quezon City, Philippines (oral presentation) 63. Bacabac RG, Licup AJ, Ayade HL, Villaruz LGM, Bernido CC, Carpio-Bernido MV, Otadoy RE, Biorheology: Stretching of Polymers Probed by Counting Winding Events, 31st Annual Meeting & Symposium (31APAMS): Science Engineering Education, Research and Innovation Toward National Development and Global Competitiveness, June 15-18, 2011, National Institute of Physics, National Science Complex, University of the Philippines, Diliman, Quezon City, Philippines (oral presentation) |