INTERMEDIATE

End Use

• (2S, 4S,5S)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4,5-dihydroxy-2-isopropylpentanamide

• 2-(3-methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene)
• (R)-3,6-diethoxy-2,5-dihydro-2-isopropylpyrazine

Aliskiren

• 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

Amisulpride   

• 3-Methyl-8-quinolinesulphonylchloride
• Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate

Argatroban  

• (R)-2-(benzhydrylsulfinyl) acetic acid

Armodafinil

o        5-chloro-2-methyl-2,3-dihydro-dibenz0[2,3;6,7]-oxepino[4,5-c]pyrrole(2H)-one

Asenapine

• (2R, 3S)-1, 2-Epoxy-3-N-(tert-butoxycarbonyl) amino-4-phenylbutane tert-Butyl 2-(4-(pyridin2yl)benzyl)hydrazinecarboxylate
• N-(Methoxycarbonyl)-L-tert.Leucine:
• [S-(R*, R*)]-beta-amino-alpha-[[1-[[4-(pyridinyl)phenyl]methyl]hydrazino]methyl]Benzenepropanol
• (S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoic acid

Atazanavir

• R)--BoroLeu-(+)-Pinanediol-CF3COOH

• (R)-BoroLeu-(+)-Pinanediol-HCl    
• N-[(1S)-1-benzyl-2-({(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo [6.1.1.0~2,6~] dec-4-yl]butyl}amino)-2-oxoethyl]
  -2-pyrazinecarboxamide   

Bortezomib

• 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione
• 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

Bosentan  

• 3,4-Dihydro-6-chloro-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide

Brinzolamide

• Fluorocytosine
• 2´,3´-di-O-acetyl-5´deoxy-5-fluorocytidine
• 5-deoxy-1’2’3’-tri-o-acetyl-β-D-ribose

Capecitabine

• D-Serine

D-Cycloserine

• 3,5-Di-p-toluyl-methyl-2-deoxyD-ribofuranoside

• 1-(2'-Deoxy-3,5'-di-p-toluyl-B-D-ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3,5,-triazine ( or Alpha + Beta mixture)

Decitabine

• Artemisinin

Dihydroartemisinin/ Artesunate / Artemether / AlphaBeta Arteether

• (2R,3S)-3-Phenylisoserine hydrochloride
• (4S,5R)-3-T-BOC-2-paramethoxyphenyl-4-phenyloxazolidine-5-carboxylic acid

Docetaxel

• D-1:(±)-6-methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
• D-2:trans-6-methyl-4-ethylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide

Dorzolamide    

• 2,5-Bis-Trifluoromethyl aniline

Dutasteride   

• (R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole

Eletriptan 

• (1S,3R,4S)-2-amino-9-[4-(benzyloxy)-3-(benzyloxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one

Entecavir

• ethyl4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
• 6,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one

Erlotinib

• Beta-Methyl vinyl phosphate (MAP) : P-Nitrobenzyl(4R,5S,6S)-3-(diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate,
• Side Chain for Ertapenem : 3-［［［（2S，4S）-4-mercapto-1-（4-nitrobenzyloxy）carbonyl-2-pyrrolidinyl］carbonyl］amino］benzoic　acid；（2S，4S）-2-［［（3-carboxyphenyl）amino］carbonyl］-4-mercapto-1-（4-nitrobenzyl pyrrolidinecarboxylate

Ertapenem   

• Ethyl 2-(3-formyl-4-iso butoxyphenyl)-4-methylthiazole-5-carboxylate
• Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Febuxostat  

• F9: 3-Oxo -4,4 aza 5 alpha androstone -17 beta butyl Carboxamide
• F9 acid：4-Aza-5 Alpha-Androstan-3-One-17Beta-Carboxylic Acid

Finasteride

• 2,3,5-Tri-O-benzyl-D-arabinofuranose-1-(4-nitrobenzoate)

Fludarabine

• T-butyl(E)-7-[3’(4”-flurophenyl)-1’methylethyl-indol-2’-yl]-3-hydroxy-5-oxo-6-heptenoate

Fluvastatin 

• 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate
• 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate

Gemcitabine

• 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-napthyridine-3-carboxylic acid CAS No.: 100361-18-0
• (3Z)-4-(aminomethyl)-O-methyloxime-3-pyrrolidinone dimethanesulfonate

Gemifloxacin Mesylate   

• 4-Turtbutyl-4-Chloro Butyro Phenone

Ibastine

• 7-ethyl-10-hydroxy campothecin
• (+)-Camptothecin

Irinotecan hydrochloride

o        (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane hydrochloride

o        7,8-dimethoxy-1,3-dihydro-2H-3-Benzazepin-2-one

o        7, 8-Dimethoxy-1,3,4,5-tetrahydro-benzo[D]Azepin-2-one

o        4,5-Dimethoxy-1-cyanobenzocyclobutane     

Ivabradine hydrochloride  

• 5-[4-({3-chloro-4-[(3-fluorobenzyl)oxy] phenyl} amino)quinazolin-6-yl]-2-furaldehyde
• 2-(Methylsufonyl)ethylamine HCl
• N-[3-chloro-4-(3-fluorobenzyloxy)-Phenyl]-6-iodoquinazolia-4-amine

Lapatinib

o        (-)-Corey lactone 4-phenylbenzoate alcohol

o        (-)-Corey lactone benzoate

o        Dimethyl (2-oxo-4-phenylbutyl)phosphonate

Latanoprost   

• (S)-2-aminobutanamide HCL ( SABAM )

Levetiracetam

• L6:16,16-difluoro-9,15-dihydroxy-11-[(tetrahydro-2H-pyran-2-yl)oxy](5Z,9a,11a)-(9Cl)-prost-5-en-1-oic acid, benzyl ester

Lubiprostone   

• 9 H Flurene
• ALPHA- (DIBUTYLAMINOMETHYL)-2,7-DICHLORO-4-FLUORENEMETHANOL
• 2,7-DICHLORO FLUORENE 

Lumefantrine

• 1-Bromo-3,5- dimethyladamantane
• 1,3 Dimethyl adamantane (1,3 dimethyl tricyclo [3.3.1.13,7] Decane

Memantine hydrochloride     

• (1R,2S)-2-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenyl-1-cyclopropane carboxamide

Milnacipran

• 1-(Mercaptomethyl)-cyclopropaneacetic acid
• 1-(1-(s)-(3-(2-(7-chloro-2-qionolinyl)-ethenyl-phenyl)-3-hydroxy-propyl)phenyl)-2-propanol

Montelukast Sodium     

• Nonane compound: [S,S]-2,8-Diazabicyclo[4,3,0] nonane

Moxifloxacin Hcl

• Trans 4-Isopropyl cyclohexane carboxylic acid

Nateglinide

• DMDO-CL （4-Chloromethyl-5-methyl-1,3-dioxol-2-one）
• Trityl Olmesartan
• Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Olmesartan medoxomil  

• 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic acid 
• (3(Dimethylamino)propyl)triphenylphosphonium bromide hydrobromide

Olopatadine Hcl

• (1R,2R)-(-)-1,2-diaminocyclohexane
• Potassium tetrachloroplatinate(Ⅱ)

Oxaliplatin

• (4S,5R)-2-(4methoxyphenyl)-N-benzoyl-4-phenyl-oxazolidine-5-carboxylic acid
• MTSC-7: N-benzoyl-(3S,2R)-3-phenylisoserine methyl ester

Paclitaxel

• 6-Oxa-2-azabicyclo [3.2.1] octan-7-one, 2-(1-phenylethyl)-, [1R-[1α，2（S*），5α]]-（9Cl） 175671-4-7

Palinavir

• 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Paliperidone  

• S-(-)-3-Aminoquinuclidine dihydrochloride
• 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid
• (S)-N-1azabicyclo[2.2.0]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide

Palonosetron  

• (+/-)Trans-3-ethoxy carbonyl-4-(4-flurophenyl)-N-methyl piperidine-2,6-dinone
• (+/-)trans-4R-(4-fluorophenyl)-3S-hydroxymethyl-1-methylpiperidine
• 4, (-)trans-4R-(4-fluorophenyl)-3S-hydroxymethyl-1-methylpiperidine
• N-methyl paroxetine
• Paroxetine Base

Paroxetine.  

• 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-5-yl)ethylbenzoic acid

Pemetrexed Disodium 

• 2-cyclopropyl-3-[(diphenylphosphinyl) methyl]-4-(4-fluorophenyl)-Quinoline 
• Tert-Butyl Pitavastatin

Pitavastatin

• (5R-cis)-Toluene-4-sulfonicacid -(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl ester              
• 2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one

Posaconazole 

• S-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

Pramipexole   

• 4, 5, 6, 7-tetrahydrothieno [3, 2-c] pyridine-2-(3H)-one. hydrochloride
• Cyclopropyl 2-fluorobenzyl ketone

Prasugrel

• Ethyl 4-acetoxy-6,7-difluoro-2-(ethylthio) quinoline-3-carboxylate(PL-7)
• Ethyl 6,7-Difluoro-1-methyl-4-oxo-1H, 4H[1,3]thiazeto (3,2-a) quinoline-3-carboxylate

Prulifloxacin

• Methyl 2-(2-(benzyloxycarbonylamino)propan-2-yl)-5,6-dihydroxypyrimidine-4-carboxylate
• 2-(2-(benzyloxycarbonylamino)propan-2-yl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate
• Benzyl2-(4-(4-fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl) propan-2-ylcarbamate
• 2-(2-aminopropan-2-yl)-1-ethyl-N-(4-fluorobenzyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide
• potassium 5-methyl-1,3,4-oxadiazole-2-carboxylate
• Raltegravir base

Raltegravir Potassium

• (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine

Ramelteon

• (R)-(-)-1-Aminoindane

Rasagiline Mesylate

• 5-hydroxymethyl thiazole

Ritonavir int.

• Z-7: 4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino]`pyrimidine-5-yl-methanol
• D-5:(4r-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-aceticacid,1,1-dimethyethyl ester
• J-6: Methyl(3r)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanoate

Rosuvastatin Calcium

• (S)-7-[(tert-butoxycarbonyl)amino]-5-azaspiro[2.4]heptane
• 3-chloro-2,4,5-trifluorbenzoic acid

Sitafloxacin  

• 3-(trifluoromethyl)-5,6,7,8 -tetrahydro[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 
• Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

Sitagliptin Phosphate

o        (R)-3-Quinuclidinol hydrochloride

Solifenacin   

• 4-(4-aminophenoxy)-N-methylpicolinamide

Sorafenib Tosylate

o        2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-1H-benzimidazole

o        Methyl-4'-(bromomethyl)-1,1'-biphenyl-2-carboxylate

Telmisartan.

• Toluene-4-sulfonicacid3-(2-ethoxy-5-methylphenyl)-3-phenyl-propylester
• 2-methoxy-5-methyl-N,N-bis(1-methylethyl)-3-phenylbenzenepropanamine fumarate

Tolterodine      

o        (-)-Corey aldehyde p-phenylbenzoate

o        (-)-Corey aldehyde benzoate

Travoprost

• CBZ-L-Valine

• BOC-L-Valine

Valacyclovir

• 10-aza-tricyclo [6.3.1.0] dodeca-2,4,6-trione
• 1-(4,5-diamino-10-aza-tricyclo[6.3.1.0]dodeca-2,4,6-trien-10-yl)-2,2,2-trifluoro-ethanone
• 1,2,3,4-Tetrahydro-1,4-methano-naphthalene-2,3-diol

Varenicline Tartarate   

• 1-aminoadamantan-3-ol
• (2S)-1-(chloroacetyl) pyrrolidine-2-carbonitrile

Vildagliptin   

o      (2R,3S/2S,3R)-3-(4-Chloro-5-Fluoro-6-Pyrimidinyl)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-yl)-2-Butanol HCl (n-2)

o      (2R,3S/2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (n-1)

o      1-(2,4-Difluoro-phenyl)-2-[1,2,4]triazol-1-yl-ethanone

Voriconazole   

• 3-Chloro-1, 2,Benzisothiazole
• 3-piperazinylbenzisothiazole Hydrochloride
• 6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2h-indol-2-one

Ziprasidone   

o        (S)-4, (4-aminobenzyl)-2-oxazolidinone

o        4,4-diethoxy-N,N-dimethyl-butan-1-amine

Zolmitriptan   

• 1,2-Benzisoxazole-3-methanesulfonic acid sodium salt CAS:  73101-64-1

Zonisamide

• 6-(5-chloro-2-pyridyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione
• 6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydroprolo(3,4b)pyrazine

Zopiclone & Eszopiclone