Retin-A is a synthetic derivative of naturally occurring vitamin A which may work by its effect on the way cells differentiate and mature. It helps to make the skin more evenly pigmented and have more of a dewy appearance or glow. In recent years scientific studies have shown that Retin-A, retinoic acid or tretinoin, may have some effect if used for 6-12 months in reversing some skin problems. This is in contrast to the myriad of cosmetic products which make inflated claims (in addition to having inflated prices), and which lack scientific validity.

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The top of the plug may be white (whitehead) or dark (blackhead). If it ruptures, the material inside, including oil and bacteria, can spread to the surrounding area and cause an inflammatory reaction. If the inflammation is deep in your skin, the pimples may enlarge to form firm, painful cysts. Acne commonly appears on the face and shoulders, but may also occur on the trunk, arms, legs, and buttocks.

Use Retin-A exactly as your doctor has prescribed it for you. Using more medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects. Do not use Retin-A for longer than your doctor has prescribed. Wash your hands before and after applying Retin-A. Before applying, clean and dry the skin area to be treated. Applying Retin-A to wet skin may cause skin irritation. If you use Renova, wait at least 20 minutes after washing your face before applying a thin layer of the medication.

Stop using Retin-A medication and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Other, less serious side effects are more likely to occur. Keep using the medication and talk to your doctor if you have any of these side effects: burning, warmth, stinging, tingling, itching, redness, swelling, dryness, peeling, irritation, or discolored skin.

During the early weeks of therapy, an apparent exacerbation of inflammatory lesions may occur. This is due to the action of the medication on deep, previously unseen lesions and should not be considered a reason to discontinue therapy.

Therapeutic results should be noticed after two to three weeks but more than six weeks of therapy may be required before definite beneficial effects are seen.

Retin-A (tretinoin) Cream contains tretinoin in either of three strengths, 0.1%, 0.05%, or 0.025% by weight, in a hydrophilic cream vehicle of stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water.

Take the following self-care steps to lessen the effects of acne:

- Clean your skin gently with a mild, non-drying soap (such as Dove, Neutrogena, or Basics). Remove all dirt or make-up. Wash once or twice a day, including after exercising. However, avoid excessive or repeated skin washing.
- Shampoo your hair daily, especially if it's oily. Comb or pull your hair back to keep the hair out of your face. Avoid tight headbands.
- Try not to squeeze, scratch, pick, or rub the pimples. Although it might be tempting to do this, it can lead to scarring and skin infections.
- Avoid touching your face with your hands or fingers.
- Avoid greasy cosmetics or creams. Look for water-based or "non-comedogenic" formulas. Take make-up off at night.

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