My research investigates the molecular
mechanisms of fluid secretion by the renal (Malpighian) tubules of the mosquito (Aedes aegypti). The Aedes mosquito is one of the most important vectors for spreading the viral-based illnesses of yellow fever and dengue fever to humans. Malpighian tubules are the kidneys of insects. Our kidneys filter our blood to produce a urine, but the Malpighian tubules of insects must actively secrete fluid to produce a urine. I am interested in deciphering how mosquitoes produce urine, because it is vital to their survival after consuming a human blood meal. That is, the Malpighian tubules excrete the excess fluid and salts absorbed from the blood they ingest. If we can identify key genes/proteins involved with urine production by mosquito Malpighian tubules, then we may be able to interfere with this process via genetic disruption or pharmacological agents, thereby making it less likely for a mosquito to bite another person and spread disease. Click here for a link to an article by the Cornell Chronicle on our research. Please send me an e-mail (pmp26@cornell.edu) if you are interested in participating in this research as a graduate student. |
