Peter Jedlička, MD, PhD  NeuroScience Center, Clinical Neuroanatomy (Anatomy I) Johann Wolfgang Goethe-University Theodor-Stern-Kai 7, D-60590 Frankfurt am Main Phone: ++49 (69) 6301 87126 Email: jedlicka @ em . uni-frankfurt . de Research interests My long term interest is to better understand how the complex structure of neurons and dynamical intracellular signaling in dendrites and at synapses affect computational properties of the nervous system. My broader, philosophical motivation is to explore whether it is possible to entirely reduce human cognition to neuronal computation. I use approaches that are based on a close interaction between computational modeling and experimental methods. I am focusing on the following special topics: * GABAergic inhibitory transmission regulates membrane potential dynamics in neuronal cells thereby crucially controlling excitability in the brain. The efficacy of synaptic inhibition is dynamic and strongly depends on ionic driving force for the chloride-permeable receptors. I want to learn more about general rules that govern spatio-temporal ionic dynamics at inhibitory synapses and their effects on dendritic computation. To address this important issue I have recently created a model of chloride accumulation and diffusion in morphologically realistic dendritic trees (Jedlicka et al. Hippocampus 2011). The model allowed us to study activity-dependent changes of intracellular chloride concentration and their impact on synaptic inhibition (see also Doyon et al. Plos Comput Biol 2011) * In my neurophilosophical musings, I am fascinated by the quandary whether scietific exploration of neural mechanisms of mental activity undermines our traditional understanding of personal freedom and responsibilty (Jedlicka TICS 2005) Publications Articles in peer-reviewed journals
Benuskova L, Jedlicka P (2012) Computational modelling of long-term depression of synaptic weights: insights from STDP, metaplasticity and spontaneous activity. Neural Network World Vlachos A, Becker D, Jedlicka P, Winkels R, Roeper
J, Deller T (2012) Entorhinal
denervation induces homeostatic synaptic scaling of excitatory postsynapses of
dentate granule cells in mouse organotypic slice cultures. PLoS One 7(3):e32883 pdf supplement Jedlicka P, Owen M,
Vnencak M, Tschäpe JA, Hick M, Müller UC, Deller T (2012) Functional
consequences of the lack of amyloid precursor protein in the mouse dentate
gyrus in vivo. Experimental Brain Research 217:441-447 pdf Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I (2010) CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J, 29(14):2421-32. pdf, supplement Jedlicka P, Deller, T, Schwarzacher SW (2010) Computational modeling of GABAA receptor-mediated paired-pulse inhibition in the dentate gyrus. Journal of Computational Neuroscience, 29:509–519 pdf Poulopoulos A, Aramuni G, Meyer G, Soykan T, Hoon M, Papadopoulos T, Zhang M, Paarmann I, Fuchs C, Harvey K, Jedlicka P, Schwarzacher SW, Betz H, Harvey RJ, Brose N, Zhang W, Varoqueaux F (2009) Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron, 63:628-42 pdf
Jedlicka P, Papadopoulos T, Deller T, Betz H, Schwarzacher SW (2009) Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo. Molecular and Cellular Neuroscience, 41:94-100 pdf Winkels R*, Jedlicka P*, Weise F, Schultz C, Deller T, Schwarzacher SW (2009) Reduced excitability in the dentate gyrus network of ßIV-spectrin mutant mice in vivo. Hippocampus, 19:677-86 pdf Vlachos A, Maggio N, Jedlicka P (2008) Just in time for late-LTP: A mechanism for the role of PKMzeta in long-term memory. Communicative & Integrative Biology, 1:190-1 pdf Jedlicka P*, Schwarzacher SW*, Winkels R, Kienzler F, Bramham CR, Frotscher M, Schultz C, Bas Orth C, Deller T (2009) Impairment of in vivo theta-burst LTP and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus, 19:130-140 pdf Jedlicka P*, Vlachos A*, Schwarzacher SW, Deller T (2008) A role for the spine apparatus in LTP and spatial learning. Behav Brain Res 192:12-9 pdf Kienzler F, Jedlicka P, Vuksic M, Deller T, Schwarzacher SW (2006) Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse. Brain Res 1085(1):195-8 pdf Jedlicka P, Backus KH (2005) Inhibitory transmission, activity-dependent ionic changes and neuronal network oscillations. Physiol Res 55:139-149 pdf Jedlicka P (2005) Neuroethics, reductionism and dualism. Trends Cogn Sci 9:172 pdf Jedlicka P (2002) Synaptic plasticity, metaplasticity and BCM theory. Bratisl Med J 103:137-43 pdf * Joint first authors Book chapters, conference proceedings
Jedlicka P (2011) Ist Bewusstsein etwas Neues unter der Sonne? Panpsychismus und Neurowissenschaften. In: Tobias Müller / Heinrich Watzka (Hrsg.), Ein Universum voller ‚Geiststaub’? Der Panpsychismus in der aktuellen Geist-Gehirn-Debatte, Mentis Verlag, Paderborn, pp. 195-222 pdf Jedlicka P (2007) Quantum stochasticity and neuronal computations. Quantum Mind 2007 Conference, Salzburg abstract ppt Jedlicka P (2007) Physical complexity and cognitive evolution In: Gershenson C, Aerts D, Edmonds B (eds), Worldviews, science and us, World Scientific Publishing, Singapore, pp. 221-23 pdf ppt Jedlicka P, Hulin I (2005) Computational models and biology (in Slovak) In: Hulin I (ed), An introduction to scientific research 2, Slovak Academic Press (SAP), Bratislava, pp. 33-41 pdf Jedlicka P, Benuskova L, Macakova J, Ostatnikova D (2002) Molecular Mechanisms of Learning and Memory (in Slovak) In: Hulin I (ed), Pathophysiology, 6th edition, Slovak Academic Press (SAP), Bratislava, pp. 1183-1199 pdf
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The free man owns himself. He can damage himself with either eating or drinking; he can ruin himself with gambling. If he does he is certainly a damn fool, and he might possibly be a damned soul; but if he may not, he is not a free man any more than a dog. (Gilbert Keith Chesterton)
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