Evolution has crafted vertebrates with two exquisitely elaborate systems each specialized to perform their unique and vital functions: the nervous and vascular systems.  These two systems are wired intimately to perform many physiological processes such as energy metabolism and hemodynamic control.  However, in contrast to our advanced understanding of neural circuit assembly, how the architecture of the neurovascular system is wired and subsequently establishes the proper functional unit in the mammalian brain is still poorly understood.  Using a combination of advanced mouse genetic, histological, molecular and cellular approaches, we will investigate basic principles of brain neurovascular development and disease pathogenesis and will facilitate the development of therapeutic strategy for curing neurological disorders.