Our missionThe Neuroinformatics and Image Analysis Laboratory of The Neuroscience Research Group at The Department of Biomedicine, UoB concentrates on working at the intersection of neuroscience and information science. The laboratory, headed by Prof. Arvid Lundervold, focuses on methods and technologies for quantitative analysis of neurobiological signals and the modeling of neuroimaging recordings. This in order to achieve better understanding of brain structure and function in health and disease. The laboratory is active in interdisciplinary training of students and researchers, and has also a link to The Department of Radiology at Haukeland University Hospital. We have extensive interactions with researchers in applied mathematics, computer science and engineering both at The University of Bergen (MedViz, BBG) and abroad (Germany, Poland, France, Spain, UK). Our Lab is a partner in European Networks (e.g. COST NeuroMath) and bilateral student and researcher exchange programs (Erasmus, Aurora, DAAD, NILS). During the past five years our laboratory has produced five PhDs (under joint supervision) and more than 20 journal papers and conference proceedings, spanning from fMRI, neurodynamics and consciousness to perfusion analysis and cell segmentation. • Hablitz J, Lundervold A. Hippocampal excitability and changes in extracellular potassium. Experimental Neurology 1981;71:410-420 [PDF] (ante laboratorium Bergensis) • Lundervold A, Moen K, Taxt TM. Automatic recognition of normal and pathological tissue types in MR images: A feasibility study using contextual classification methods. Proceedings of the NOBIM Conference, Oslo, Norway, June 2-3 1988:189-192 (Norwegian Computing Center, Technical Report No. 818) . See also p. 294 in Hjort NL, Omre H. Topics in spatial statistics, Scand J Stat 1994;21(4):289-357. [JSTOR] • Lundervold A, Godtliebsen F. Noise reduction and brain tissue classification in MR images. Conference Record of the 1992 IEEE Nuclear Science Symposium and Medical Imaging Conference, Orlando, FL, Oct 25-31 1992; vol.2:1265-1267 [PDF] • Taxt T, Lundervold A, Fuglaas B, Lien H, Abeler V. Multispectral analysis of uterine corpus tumors in magnetic resonance imaging. Magnetic Resonance in Medicine 1992;23:55-76. [PubMed] • Lundervold AJ, Reinvang I, Lundervold A. Characteristic patterns of verbal memory function in patients with Huntington’s disease. Scandinavian Journal of Psychology, 1994;35:38-47. [PubMed] • Stugaard M, Steen T, Lundervold A, Smiseth OA, Ihlen H. Visual assessment of intraventricular flow from colour M-mode Doppler images. International Journal of Cardiac Imaging, 1994;10:279-287. [PubMed] • Taxt T, Lundervold A. Multispectral analysis of the brain in magnetic resonance imaging. IEEE Transactions on Medical Imaging, 1994;13:470-481. [HTML] [PDF] • Holden M, Steen E, Lundervold A. Segmentation and visualization of brain lesions in multispectral magnetic resonance images. Computerized Medical Imaging and Graphics, 1995;19:171-183. [PDF] • Lundervold A, Ersland L, Gjesdal KI, Smievoll AI, Tillung T, Sundberg H, Hugdahl K. Functional magnetic resonance imaging of primary visual processing using a 1.0 T scanner. International Journal of Neuroscience, 1995;81:151-168. [PubMed] • Lundervold A, Storvik G. Segmentation of brain parenchyma and cerebrospinal fluid in multispectral magnetic resonance images. IEEE Transactions on Medical Imaging, 1995;14:339-349. [PDF] • Ersland L, Rosen G, Lundervold A, Smievoll AI, Tillung T, Sundberg H, Hugdahl K. Phantom limb imagery fingertapping causes primary motor activation: An fMRI study. NeuroReport, 1996;8:207-210. [PDF] • Lundervold A, Duta N, Taxt T, Jain A. Model-guided segmentation of corpus callosum in MR images. IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR'99) 1999; Vol. 1, pp. 231-237. [HTML] [PDF] • Hugdahl K, Lundervold A, Ersland L, Smievoll AI, Sundberg H, Barndon R, Roscher B. Left frontal activation during a semantic categorization task: an fMRI study. International Journal of Neuroscience, 1999;99:49-58. [PubMed] • Lundervold A, Taxt T, Ersland L, Fenstad AM. Volume distribution of cerebrospinal fluid using multispectral MR imaging. Medical Image Analysis, 2000;4(2):123-136. [PDF] • Thomsen T, Hugdahl K, Ersland L, Barndon R, Lundervold A, Smievoll AI, Roscher BE, Sundberg H. Functional magnetic resonance imaging (fMRI) study of sex differences in a mental rotation task. Medical Science Monitor, 2000;6:1186-1196. [PubMed] • Heiervang E, Hugdahl K, Steinmetz H, Smievoll AI, Stevenson J, Lund A, Ersland L, Lundervold A. Planum temporale, planum parietale and dichotic listening in dyslexia. Neuropsychologia 2000;38:1704-1713. [PDF] • Rosen G, Hugdahl K, Ersland L, Lundervold A, Smievoll AI, Barndon R, Sundberg H, Thomsen T, Roscher BE, Tjølsen A, Engelsen B. Different brain areas activated during imagery of painful and non-painful ‘finger movements’ in a subject with an amputated arm. NeuroCase, 2001;7:255-260. [PubMed] • Hugdahl K, Rosen G, Ersland L, Lundervold A, Smievoll AI, Barndon R, Thomsen T. Common pathway in mental imagery and pain perception: an fMRI study of a subject with an amputated arm. Scandinavian Journal of Psychology, 2001;42:269-275. [PDF] • Landrø NI, Rund BR, Lund A, Sundet K, Mjellem N, Asbjørnsen A, Thomsen T, Ersland L, Lundervold A, Smievoll AI, Egeland J, Stordal KI, Roness A, Sundberg H, Hugdahl K. Honig’s model of working memory and brain activation: an fMRI study. Neuroreport 2001; 12(18):4047- 4054. [PubMed] • von Plessen K, Lundervold A, Duta N, Heiervang E, Klauschen F, Smievoll AI, Ersland, Hugdahl K, Less
developed corpus callosum in dyslexic subjects - A structural MRI study. Neuropsychologia
2002;40(7):1035-1044. [PDF]
• Lund A, Kroken R,
Thomsen T, Hugdahl K, Smievoll AI, Barndon R, Iversen J, Landrø NI, Sundet K, Rund BR, Ersland L,
Lundervold A, Asbjørnsen A. “Normalization”
of brain activation in schizophrenia: an fMRI study. Schizophrenia Research 2002;58:333-335. [PDF]
• Lundervold AJ, Lundervold A, Hugdahl K. A
multivariate classification study of attentional
orienting in patients with right hemisphere lesion. Neuropsychiatry, Neuropsychology, and Behavioral Neurology,
2002;15(4):232-246. [PubMed]
• Hugdahl K, Heiervang E, Ersland L, Lundervold A, Steinmetz H, Smievoll A-I.
Significant relation between MR measures of planum temporale area and
dichotic processing of syllables in dyslexic children. Neuropsychologia 2003;41:666-675. [PubMed]
• Thorsen F, Ersland L, Nordli H, Enger PØ, Huszthy PC, Lundervold A, Standnes T, Bjerkvig R,
Lund-Johansen M. Imaging of experimental rat gliomas using a
clinical MR scanner. Journal of Neuro-Oncology
2003;63:225-231. [PDF]
• Lysaker M, Lundervold A, Tai X-C. Noise
removal using fourth-order partial differential equations with applications to
medical magnetic resonance images in space and time. IEEE Transactions on Image Processing
2003;12:1579-1590 (also as Technical report (CAM-02-44), Department of
Mathematics, UCLA) [PDF]
• Walhovd KB, Fjell AM, Reinvang I, Lundervold A, Fischl B, Quinn
BT, Dale AM. Size does matter in the long run: hippocampal and
cortical volume predict recall across weeks. Neurology
2004;63(7):1193-1197. [PubMed]
• Lundervold AJ, Andersson M, Geitung J-T, Reinvang I, Lundervold A.• Fjell AM, Walhovd KB, Reinvang I, Lundervold A, Dale
AM, Quinn BT, Makris N, Fischl B. Age
does not increase rate of forgetting over weeks: neuroanatomical volumes
and visual memory across the adult life-span. J Int Neuropsychol Society 2005;11(1):2-15. [PDF]
• Walhovd KB, Fjell AM, Reinvang I, Lundervold A, Fischl B, Quinn
BT, Makris N, Dale AM. Cortical volume and
speed-of-processing are complementary in prediction of performance
intelligence. Neuropsychologia
2005;43(5):704-713. [PDF]
• Walhovd KB, Fjell AM, Reinvang I, Lundervold A, Dale
AM, Eilertsen DE, Quinn BT, Salat D, Makris N, Fischl B.
Effect of age on volumes of cortex, white matter and subcortical
structures. Neurobiol Aging 2005;26(9):1261-1270. [PDF]
• Schad LR, Lundervold A. Influence of resolution and signal to noise ratio on MR image texture. In M. Hajek, M..Dezortova, A.Materka, R..Lerski (eds.) Texture Analysis for MR Imaging. Med4Publishing, Prague / European COST B21, 2006: pp. 129-149. ISBN 80-903660-0-7 [HTML] [PDF] • Fjell AM,Walhovd KB, Reinvang I, Lundervold A, Salat D, Quinn
BT, Fischl B, Dale AM. Selective increase of
cortical thickness in high-performing elderly: structural indices of optimal
cognitive aging. Neuroimage
2006;29(3):984-994. [PubMed]
• Brekke C, Lundervold A, Enger PØ, Brekken C, Stålsett E,
Pedersen TB, Haraldseth O, Krüger PG, Bjerkvig R, and Chekenya M. NG2
expression regulates vascular morphology and function in human brain tumours. Neuroimage 2006;29(3):965-976. [PDF]
• Engelsen B, Gramstad A,
Thomsen T, Beneventi H, Ersland L, Smievoll AI, Lundervold A, Hugdahl K. Frontoparietal
activations during delayed visuo-spatial recall in
patients with epilepsy due to hippocampal
sclerosis. Epilepsy Behav 2006;8(3):565-574. [PubMed]
• Plessen KJ, Gruner R, Lundervold A, Hirsch
J, Xu D, Bansal R, Hammar A,
Lundervold AJ, Wentzel-Larsen T, Lie SA, Gass A,
Peterson BS, Hugdahl K. Reduced white matter connectivity
in the corpus callosum of children with Tourette
syndrome. J Child Psychol Psychiatry 2006;47(10):1013-1022. [PubMed]
• Walhovd KB, Fjell AM, Reinvang I, Lundervold A, Fischl B, Quinn
BT, Makris N, Dale AM. The functional and
structural significance of the frontal shift in the old/new ERP effect. Brain Research
2006;1081(1):156-170. [PubMed]
• Hodneland E, Lundervold A, Gurke S, Tai
X-C, Rustom A, Gerdes H-H.
Automated detection of tunnelling nanotubes in 3D
images. Cytometry A 2006;69A(9):961-972. [PDF]
• Bergmann O, Kindlmann G, Lundervold A, Westin
CF. Diffusion k-tensor estimation from Q-ball imaging using discretized
principal axes. Med Image Comput Comput Assist Interv
2006;9:268-275. [PDF] • Zöllner F, Kocinski M, Lundervold A, Rørvik J. Assessment
of renal function from 3D dynamic contrast enhanced MR images using independent component analysis. Bildverarbeitung
für die Medizin 2007: 237-241. [HTML] [PDF]
• Lundervold A, Ystad M, Anderlik C. Brain imaging and computational neuroanatomy using high performance and GRID computing. NOTUR Meta Magazine 2007; No.1:6-9 [PDF] • Plessen KJ, Lundervold A, Gruner R, Hammar A,
Lundervold A, Peterson BS, Hugdahl K. Functional brain
asymmetry, attentional modulation, and interhemispheric transfer
in boys with Tourette syndrome. Neuropsychologia 2007;45(4):767-774. [PubMed]
• Lu Z, Lundervold A, Tjøstheim D, Yao
Q. Exploring spatial nonlinearity using additive approximation. Bernoulli 2007;13(2):447-472. [PDF]
• Hugdahl K, Løberg EM, Jørgensen HA, Lundervold A, Lund A,
Green MF, Rund B. Left hemisphere lateralization of
auditory hallucinations in schizophrenia: A dichotic listening study. Cognitive Neuropsychiatry 2008;13(2):166-179. [PubMed] • Balabanian J-P, Ystad M, Viola I, Lundervold A, Hauser H, Gröller E. Hierarchical volume visualization of brain anatomy. Proceedings of Vision, Modeling, and Visualization (VMV 2008), Konstanz, Germany, October 8-10, 2008. [PDF]
• Sandu AL,
Rasmussen IA, Lundervold A, Kreuder F, Neckelmann G, Hugdahla K, Specht K. Fractal dimension analysis of MR images reveals grey
matter structure irregularities in schizophrenia. Computerized Medical Imaging and Graphics 2008;32(2):150-158. [PDF]
• Sandu AL, Specht K, Beneventi H, Lundervold A, Hugdahl K. Sex-differences
in grey-white matter structure in normal-reading and dyslexic adolescents. Neuroscience Letters 2008;438(1):80-84. [PubMed]
• Bergmann Ø,
Christiansen O, Lie L, Lundervold A.
Shape-adaptive DCT for denoising of 3D scalar and
tensor values images. Journal of Digital Imaging 2009;22(3):297-308. [PDF] • Anderlik A, Munthe-Kaas, AZ, Øye OK, Eikefjord E, Rørik J, Ulvang DM, Zöllner F, Lundervold A. Quantitative assessment of kidney function using dynamic contrast enhanced MRI - steps towards an integrated software prototype. Proceedings of 6th International Symposium on Image and Signal Processing and Analysis, 2009 (IEEE ISPA 2009): 575-581. [PDF][IEEE Explore] • Öltze S, Preim B, Hauser H, Rørvik J, Lundervold A. Visual analysis of cerebral perfusion data four interactive approaches and a comparison. Proceedings of 6th International Symposium on Image and Signal Processing and Analysis, 2009 (IEEE ISPA 2009): 582-589. [PDF][IEEE Explore] • Klepaczko A, Kocinski M, Materka A, Chekenya M, Lundervold A. Texture analysis in application to quantitative study of 3D vascular tree images. Proceedings of 6th International Symposium on Image and Signal Processing and Analysis, 2009 (IEEE ISPA 2009): 730-735. [PDF] [IEEE Explore]
• Klauschen F,
Goldman A, Barra V, Meyer-Lindenberg A, Lundervold A.
Evaluation of automated brain MR image segmentation and volumetry methods.
Human Brain Mapping 2009
Apr;30(4):1310-1327. [PDF]
• Hodneland E, Bukoreshtliev N, Eichler T, Tai
XC, Gurke SD, Lundervold A, Gerdes H-H. A Unified framework for automated
3D segmentation of surface-stained living cells and a comprehensive
segmentation evaluation. IEEE Transaction on Medical Imaging 2009
28(5):720-738. [PDF]
• Zöllner FG, Sance R, Rogelj P, Ledesma-Carbayo MJ, Rørvik J,
Santos A, Lundervold A.
Assessment of 3D DCE-MRI of the kidneys using non-rigid image registration and
segmentation of voxel time courses. Comput Med Imaging Graph 2009
33(3):171-181. [PubMed]
• Ystad M,
Lundervold AJ, Wehling E, Espeseth T, Rootwelt H, Westlye LT, Andersson M, Adolfsdottir S, Geitung JT, Fjell AM, Reinvang I, Lundervold A. Hippocampal volumes
are important predictors for memory function in elderly women. BMC Medical Imaging 2009 Aug 22;9(1):17 [HTML] [PDF]
• Zöllner FG, Monsen JA, Rørvik J, Lundervold A, Schad LR.
Blood flow quantification from 2D phase contrast MRI in renal arteries using an
unsupervised data driven approach. Z
Med Phys 2009;19(2):98-107. [PubMed]
• Andersson M, Ystad M, Lundervold A, Lundervold AJ. Correlations between
measures of executive attention and cortical thickness of left posterior middle
frontal gyrus - a dichotic listening study. Behav Brain Func 2009 Oct 1;5:41. [HTML][PDF]
• Ystad M, Eichele T,
Lundervold AJ, Lundervold A. Subcortical
functional connectivity and verbal episodic memory in healthy elderly - A
resting state fMRI study. Neuroimage 2010 Aug 1;52(1):379-388. [PubMed][PDF]
• Naik M, Lundervold A, Nygaard H, Geitung JT.
Diffusion tensor imaging (DTI) in dementia patients with frontal lobe symptoms.
Acta Radiol 2010 Jul;51(6):662-668. [PubMed][PDF]
• Lundervold A. On consciousness, resting state fMRI, and neurodynamics. Nonlinear Biomedical Physics 2010 Jun 3;4 Suppl 1:S9. [PubMed] [HTML] [PDF] (extended version [PDF]) • Hodneland E, Ystad M, Haász J, Zanna Munthe-Kaas A, Lundervold A. Automated workflow for spatial alignment of multimodal MR image acquisitions in a longitudinal study of cognitive aging. In: Mastorakis N, Mladenov V, Bojkovoc Z, eds. Latest Trends on Applied Mathematics, Simulation, Modelling, WSEAS Press, 2010;264-269. (ISBN 978-960-474-210-3). [PDF]
• Losnegård A, Hysing LB, Muren LP, Hodneland E, Lundervold A. Semi-automated segmentation of the sigmoid and descending
colon for radiotherapy planning using the Fast-Marching method. Phys Med Biol 2010;55(18):5569-5584 [PDF] • Ystad M, Hodneland E, Adolfsdottir S, Haász J, Lundervold AJ, Eichele T, Lundervold A. Cortico-striatal connectivity and cognition in normal aging: a combined DTI and resting state fMRI study. Neuroimage 2011;55(1):24-31 [excerpt] [PubMed]
• Hodneland E, Ystad M, Haász J, Munthe-Kaas AZ, Lundervold A. Automated approaches for analysis of multimodal MRI acquisitions in a longitudinal study of cognitive aging. Computer Methods and Programs in Biomedicine 2011 Jun 8 [Epub ahead of print] • Westlye ET, Lundervold A, Rootwelt H,
Lundervold AJ, Westlye LT.
Increased hippocampal default mode
synchronization during rest in middle-aged and elderly APOE e4-carriers: relationships with memory performance. Journal of Neuroscience 2011;31(21):7775-7783 [PubMed]
• Kocinski M, Klepaczko A, Materka A, Chekenya M, Lundervold A. 3D image texture analysis of
simulated and real-world vascular trees. Computer Methods and Programs in Biomedicine. 2011 Jul 29 [Epub ahead of print]
• Li S, Zöllner F, Merrem AD, Peng Y, Rørvik J, Lundervold A, Schad LR. Wavelet-based segmentation of renal compartments in DCE-MRI of human kidney: initial results in patients and healthy volunteers. Computerized Medical Imaging and Graphics 2011 Jun 23 [Epub ahead of print] • Losnegård A, Lundervold A, Háasz J, Hodneland E. Fast marching tractography from multiple diffusion sensitizing directions in MR-DTI from the brain. Proceedings of the 7th International Symposium on Image and Signal Processing and Analysis (ISPA 2011), September 4-6, 2011, Dubrovnik, Croatia [PDF] • Haász J, Hodneland E, Lundervold AJ, Lundervold A. Relationship between cortical thickness and white matter fibre bundle integrity in the ageing
brain: A multimodal MRI study with tract parameterisation. Submitted. • Hodneland E, Lundervold A, Rørvik J, Munthe-Kaas AZ. Normalized gradients for multimodal registration of medical images. Submitted. • Zöllner F, et al. Assessment of kidney volumes from MR images – traditional and new acquisition and segmentation techniques. In prep.
Posters / Oral presentations• Lundervold A, Khateeb H. Numerical estimation of the BOLD response in event-related fMRI. 25th Annual INS Mid-Year Meeting, Stockholm, July 24-27, 2002. [PDF] White matter and processing efficacy in older adults. 2008 International Conference on Alzheimer's Disease (ICAD2008), Chicago, July 26-31, 2008. [PDF] [ODP] • Andersson M, Ystad M, Lundervold A, Lundervold AJ. Auditory attention control correlates with cortical thickness of posterior left middle frontal gyrus. 5th Annual Meeting of the Organization for Human Brain Mapping (HBM2009), San Francisco, CA, June 18-23, 2009. [PPT] • Losnegård A, Hysing LB, Munthe-Kaas AZ, Muren L, Hodneland E, Lundervold A. Semi-automatic segmentation of the large intestine for radiotherapy planning. 10th Biennial ESTRO Conference on Physics and Radiation Technology for Clinical Radiotherapy (ESTRO 2009), Maastricht, The Netherland, Aug 30 - Sep 3, 2009. [PDF] [LaTeX .rar] • Losnegård A, Hodneland E, Gerdes, H-H, Lundervold A. Segmentation and tracking of tubular structures in biomedical images. 2nd International Conference on Scale Space and Variational Methods in Computer Vision, Voss, Norway, June 1-5, 2009. [PDF] • Lundervold A. Consciousness- dynamical systems - resting state fMRI. Consciousness and its Measures - Joint Workshop for COST Actions Consciousness (BM0605) and Neuromath (BM0601), Limassol, Cyprus, November 29 - December 1 2009. [PDF] [LaTeX .tgz] • Ystad M, Hodneland E, Eichele T, Lundervold A. Cross-modality identification of maximal age related subcortical connectivity change - A combined resting state fMRI and diffusion tensor imaging study. Workshop of the NeuroMath COST Action BM0601 - Neurodynamic Insight into Functional Connectivity, Cognition, and Consciousness, Dubrovnik, Croatia, May 26-28, 2010. [PDF] [Abstract Frontiers] • Losnegard A, Hartveit E, Veruki ML, Karolczak L, Munthe-Kaas AZ, Kocinski M, Hodneland E, Lundervold A. Automated 3D segmentation and morphological reconstruction of retinal neurons. NevroNor: New Concepts in Neuroscience, Bergen, Norway, May 26-28 2010. [PDF][LaTeX .tgz][Abstract] • Westlye ET, Westlye LT, Rootwelt H, Lundervold AJ, Lundervold A. Increased synchronization in the memory system of healthy middle-aged and elderly APOE e4 carriers. NevroNor: New Concepts in Neuroscience, Bergen, Norway, May 26-28 2010. [PDF][Abstract] • Ystad M, Hodneland E, Adolfsdottir S, Lundervold AJ, Eichele T, Lundervold A. Subcortical structural connectivity between resting state networks in cognitive aging. NevroNor: New Concepts in Neuroscience, Bergen, Norway, May 26-28 2010. [PDF][Abstract] • Ystad M, Hodneland E, Adolfsdottir S, Lundervold AJ, Eichele T, Lundervold A. Age related cognitive changes and subcortical structural connections between resting state networks. Oral presentation at the 16th Annual Meeting of the Organization for Human Brain Mapping (HBM 2010), Barcelona, Spain, June 6-10, 2010. [PPTX][Abstract][E-poster] • Lundervold A. The role of mathematics in the study of structural and functional brain connectivity. Invited plenary talk at 4th International Conference on Applied Mathematics, Simulation, Modelling, Corfu Island, Greece, July 22-25, 2010. [PDF] [LaTeX .tgz]• Losnegård A. Fast marching tractography from multiple diffusion sensitizing directions in MR-DTI from the brain. Oral presentation at the 7th International Symposium on Image and Signal Processing and Analysis (ISPA 2011), September 4-6, 2011, Dubrovnik, Croatia [PPTX] | Lab members
Affiliated
Collaborators
Former students
Research projects & collaborations
Teaching / presentations / courses
A vision for engineering and biomedicine ... Cohen JE, 2004. Mathematics is biology’s next microscope, only better; biology is mathematics’ next physics, only better. PLoS Biol, 2(12):e439. Adapted from Palsson, BO.
Systems biology: Properties of
reconstructed networks. Cambridge University Press, 2006. |


