Mizuki Takenaka Group
Plant Molecular Genetics
Graduate School of Science, Kyoto University
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PPR proteins and C-to-U RNA editing in plant organelles
(Martin Künsting / HZB)
RNA editing in plant organelles
C-to-U RNA editing are found in almost all land plants in mitochondria and plastids. This posttranscriptional process alters specific C (cytidine) nucleotides to U (uridine), in plastids about 30-40, in mitochondria more than 500. Most of these nucleotide alterations in mRNAs convert the encoded amino acid to one better conserved in evolution, suggesting that these editing events are pivotal for the function of the protein.
We have identified and characterized two types of RNA editing factors in plant organelles, PPR type RNA editing factor and MORF (Multiple organellar RNA editing factor) proteins.
Recently, we determined structures of the DYW domain, which catalyzes the C-to-U RNA editing in plant organelles (Nature Catalysis (2021) 4, 510–522. )
