Welcome to the Kuhlman Lab. We are in the Department of Biochemisty and Biophysics at the University of North Carolina, Chapel Hill. We use a combination of computational and experimental methods to design proteins. Currently we are focusing on a variety of design goals including the creation of novel protein-protein interactions, protein structures and light activatable protein switches. Central to all of our projects is the Rosetta program for protein modeling. In collaboration with developers from a variety of universities, we are continually adding new features to Rosetta as well as testing it on new problems. Please see our research page for more information. | Recent Highlights Design of a Protein-Protein Interaction using Beta-strand Assembly (Stranges et al., PNAS 2011) Metal-mediated Affinity and Orientation Specificity in a Computationally Designed Protein Homodimer (Der et al., JACS, 2011). Computational Design of a Protein-Binding Peptide (Sammond et al, JACS, 2011). Design of a Directed Library for Protein-Protein Interface Design (Guntas et al., PNAS, 2010) Engineering of a Photoactivable GTPase (Wu et al., Nature, 2009) |







