Julien Mozziconacci, PhD Researcher
Multiscale modelling of living matter
Theoretical Physics of Condensed matter Lab Pierre and Marie Curie University, Paris email: mozziconacci@lptmc.jussieu.fr telephone: +33 1 44 27 45 40
2009 - present, Lecturer in PhysicsCondensed Matter Theory Lab, Pierre & Marie Curie University, Paris, France2008 - 2010, Research AssociateComputer Lab, Cambridge University, Cambridge, UK2006 – 2008, Postdoctoral ResearchCondensed Matter Theory Lab, Pierre & Marie Curie University, Paris, France2004 – 2006, Postdoctoral ResearchCell Biology and Biophysics, European Molecular Biology Laboratory, Heidelberg, Germany2001 – 2004, Doctoral ResearchCondensed Matter Theory Lab, Pierre & Marie Curie University, Paris, France2004 Ph.D. PhysicsCondensed Matter Theory Lab, Pierre & Marie Curie University, Paris, France Thesis: Multi-scale Modeling of Chromatin during the Cell Cycle.Advisor: Jean-Marc Victor Manuscript in French 2001 M.S. PhysicsPierre & Marie Curie University, Paris, FranceModeling, Dynamics and Statistics of Complex Systems. PublicationsMy publications in PubMed Publications in peer reviewed journals13. Nucleosome positioning and nucleosome stacking: two faces of the same coin. PDFRiposo J, Mozziconacci J. MOLECULAR BIOSYSTEMS. 2012 Jan 23.PMID:22266567 12.Co-transcriptional architecture in a Y loop in Drosophila melanogaster. PDF Redhouse JL, Mozziconacci J, White RA. CHROMOSOMA. 2011 May 10.PMID: 21556802 11.Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide. PDF Botta M, Haider S, Leung IX, Lio P, Mozziconacci J. MOLECULAR SYSTEMS BIOLOGY 2010 Nov 2;6:426.PMID: 21045820 10. Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin. PDF Bancaud A, Huet S, Daigle N, Mozziconacci J, Beaudouin J, Ellenberg J. EMBO J. 2009 Nov 19. PMID: 19927119 9. A molecular model of chromatin organisation and transcription: how a multi-RNA polymerase II machine transcribes and remodels the beta-globin locus during development. PDF Wong H, Winn PJ, Mozziconacci J. BIOESSAYS. 2009 Oct 29;31(12):1357-1366. PMID: 19877003  Revaud D, Mozziconacci J, Sabatier L, Desmaze C, Lavelle C. CELL CYCLE. 2009 Apr 4;8(7)  7. Tubulin dimers oligomerize before their incorporation into microtubules PDF Mozziconacci J, Sandblad L, Wachsmuth M, Brunner D and Karsenti E. PLoS ONE 3(11): e3821. doi:10.1371/journal.pone.0003821(2008) 6. An all-atom model of the chromatin fiber containing linker histone reveals a versatile structure tuned by nucleosomal repeat length. PDF Wong H, Victor JM., Mozziconacci J. PLoS ONE 2(9): e877. doi:10.1371/journal.pone.0000877 (2007) Discussed in the May 2008 issue of Chemistry world: "pulling our strings". 5. Nucleosome chiral transition under positive torsional stress in single chromatin fibers. PDF Bancaud A, Wagner G, Conde E Silva N, Lavelle C, Wong H, Mozziconacci J, Barbi M, Sivolob A, Le Cam E, Mouawad L, Viovy JL, Victor JM, Prunell A. MOLECULAR CELL 27(1):135-47. (2007) See the CNRS press release 4. Torsional manipulation of single chromatin fibers reveals a highly flexible structure. PDF Bancaud A, Cond e Silva N, Barbi M, Allemand JF, Mozziconacci J, Lavelle C, Croquette V, Victor JM, Prunell A, Viovy JL. NATURE STRUCTURAL AND MOLECULAR BIOLOGY 13(5):444-50. (2006) See the CNRS press release 3. A physical model for the condensation and decondensation of eukaryotic chromosomes. PDF Mozziconacci J, Lavelle C, Barbi M, Lesne A, Victor JM. FEBS LETTERS 580(2):368-72.(2006). 2. How the chromatin fiber deals with topological constraints. PDF Barbi M, Mozziconacci J and Victor JM. PHYSICAL REVIEW E 71 (3 Pt 1):031910 (2005). Presented in Nature ”News and views” Vol. 429 and in the American Mathematical Society Maths in the Media. Selected for the April 1, 2005 issue of Virtual Journal of Biological Physics Research. 1. Nucleosome gaping supports a functional structure for the 30 nm chromatin fiber. PDF Mozziconacci J, Victor JM. JOURNAL OF STRUCTURAL BIOLOGY 148 72–76 (2003). Conference abstractsGraphical Modeling of the Beta-Globin Transcription FactoryWong, H. and Mozziconacci, J. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS Volume: 26 Issue: 6 (2009) All-atom model of the chromatin fiber : a versatile structure tuned by the repeat length Mozziconacci J., Wong H. and Victor J.M. FEBS JOURNAL Volume: 274 Pages: 78 ( 2007) Chromatin structure and macromolecular confinement. Bancaud A, Daigle N,Mozziconacci J and Ellenberg J. BIOPHYSICAL JOURNAL 14 A Suppl (2007) Chapters in booksChromatin fiber: 30 years of modelsMozziconacci J. and Lavelle C. COMPUTATIONAL BIOLOGY: NEW RESEARCH, Nova Science Publishers (2008) Work in progressResearch achievements
EMBL Conference: From functional genomics to systems biology, Heidelberg, Germany, November 2010 EMBL Conference: Chromatin and transcription, Heidelberg, Germany, August 2010 DNA Topology course, OIST, Okinawa, Japan, November 2009 Albany 2009, The 16th Conversation, Albany, U.S., June 2009 Biophysics of Chromatin Workshop, Heidelberg, Germany, February 2009
FEBS Congress on ”Molecular Machines”. Vienna, Austria, 2007. Contributed poster, “Modeling the chromatin fiber from EM-imaging.” Gordon Research Conference on ”Nucleic Acids”. Newport, USA, 2007. Contributed poster, “All-atom structure of the chromatin fiber.” 2nd International PhD Symposium on ”Decoding Nature: Hierarchy of interactions”, Gottingen, Germany, 2005. Contributed talk, “How does the chromatin fiber deals with topological constraints.”
Comparative genomics of vertebrates: concepts and bio-informatics tools. La Londe-Les-Maures, France, 2004. DNA and chromosomes. Cargese, France, 2004. Contributed poster, “A physical model for the compaction of the mitotic chromosome” Physics of the cell. Les Houches, France, 2004. Contributed talk, “How does the chromatin fiber deals with topological constraints.” Understanding Molecular Simulation. Amesterdam, Netherlands, 2002.
Teaching in High School : Physics and Chemistry at the Carnot high school in Paris, May and June 2002. Teaching at the University : Physics (basic physics, history of science and spectral analysis) My courses in french:
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