The Top Ten Facts about Paramyxoviruses
Measles, sneezles, and things that go mumps in the night
| 1. Paramyxoviridae's P gene codes for four viral proteins by a dual mechanism of internal translation initiation and reading frame shifting.
2. Paramyxoviruses undergo a complicated process of RNA editing before commencing translation. 3. Measles' characteristic rash is not caused by cytopathic effects of the virus; rather, it is a reaction of CD8+ T cells against viral antigens expressed by skin cells. Therefore, the rash is a good sign that the immune system is in working order. 4. Measles can reappear during recovery as SSPE or after up to 10 years as post-infectious encephalitis. Watch out! 5. The MMR vaccine has sparked controversy over whether it is responsible for causing autism in young children. 6. Worldwide, paramyxoviruses are responsible for half of the cases of croup, bronchitis, and pneumonia in infants. 7. RSV can persist for months even in the coldest of conditions. A study at the Antarctic base at the South Pole continually isolated these viruses from the personnel there, despite their being cut off from the outside world for several months during the winter. 8. Mumps was one of the first viruses to be recorded. Hippocrates recorded an epidemic in the 5th century B.C.E. of parotitis and orchitis. 9. Aside from their endemicity in humans, paramyxoviruses have recently been known to be harbored in Asian fruit bat reservoirs. 10. Over the past 20 years, paramyxoviruses such as Nipah and Hendra have emerged worldwide as zoonoses, reminding us that, even with our control over once common malladies as mumps and measles, we can never be too sure of our society's defenses against paramyxoviruses. |
Page created by Julie Boiko for Humans & Viruses 2007-08 at Stanford University.