•    Indicated for adjunct to diet in adults with very high triglyceride levels (greater than 500 mg/dL).

•    Effects on cardiovascular mortality and morbidity in patients with very high triglyceride levels are unknown.
 
•    Effects on the risk of pancreatitis in patients with very high triglyceride levels are unknown.

•    Mean triglyceride decrease of 45%.
 
•    Mean HDL-cholesterol increase of 13%.
 
•    Mean LDL-cholesterol increase of up to 32%.
 
•    The percent reductions and elevations are based on patients receiving fish oil 4 grams per day for four months.
 
•    Withdraw treatment if inadequate response after two months of therapy.
 
•    Effective in lowering serum triglycerides over one year in patients with CHD and combined hyperlipidaemia whose triglycerides remained
      elevated despite simvastatin treatment.
 
•    As effective as gemfibrozil in reducing serum triglyceride levels.

•    Use caution in patients with a history of sensitivity or allergy to fish.

•    Pregnancy category C: Use in pregnant women only if the potential benefit justifies the potential risk to the fetus.
 
•    Use caution in breast-feeding women, due to lack of human safety information.

•    The daily dose of fish oil should contain 4 g of EPA/DHA per day. The daily dose may be taken as a single 4 g dose or as two 2 g doses
      (2 grams given twice daily).
 
•    Patients should be placed on a standard cholesterol-lowering diet before receiving omega-3-acid ethyl esters and should continue on this
     diet during treatment with omega-3-acid ethyl esters.