Publications

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Research Articles:

  1. Han, X.* Nabb, D.L., Russell, M.H., Kennedy, G.L., and Rickard, R.W. (2012) Renal elimination of perflorocarboxylates (PFCAs). (2012) Chem. Res. Toxicol. 25, 35-46 (a review, Abstract or full text in PDF).
  2. Han, X.* Szostek, B., Yang, C.H., Cheatham, S., Mingoia, R.T., Nabb, D.L., Gannon S.A., Himmelstein, M.W., and Jepson, G.W. (2011) Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and in male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathways. Drug Metab Dispos. 39: 1288-1293. (Abstract or full text in PDF).
  3. Yang, C.H., Glover, K.P., and Han, X.* (2010) Characterization of cellular uptake of perfluorooctanoate via organic anion transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates. Toxicol. Sci. 117: 294-302. (Abstract or full text in PDF)
  4. Mingoia, R.T., Glover, K.P., Nabb, D.L., Yang, C.H., Snajdr, S.I., and Han, X.* (2010) Cryopreserved hepatocytes from rainbow trout (Oncorhynchus mykiss): a validation study to support their application in bioaccumulation assessment. Environ. Sci. Technol. 44, 3052-3058. (Abstract or full text in PDF)
  5. Yang, C.H., Glover, K.P., and Han, X.* (2009) Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in Renal Elimination of Perfluorocarboxylates in Rats. Toxicol. Lett. 190, 163-171. (Abstract or full text in PDF)
  6. Nichols, J.W., Bonnell, M., Dimitrov, S.D., Escher, B.I., Han, X., and Kramer, N.I. (2009) Bioaccumulation assessment using predictive approaches. Integr. Environ. Assess. Manag. 5, 577-597. (Abstract or full text in PDF)
  7. Han, X.*, O'Connor, J.C., Donner, E.M., Nabb, D.L., Mingoia, R.T., Snajdr, S.I., Clarke, J.J., and Kaplan, A.M. (2009) Non-coplanar 2,2',3,3',4,4',5,5',6,6'-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities. Toxicology 255, 177-186. (Abstract and full text in PDF)
  8. Han, X.*, Nabb, D.L., Yang, C.H., Snajdr, S.I., and Mingoia, R.T. (2009) Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): comparison of basal enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment. Environ. Toxicol. Chem. 28, 481-488. (Abstract or full text in PDF)
  9. Schuster, P., Bertermann, R., Snow, T.A., Han, X., Rusch, G.M., Jepson, G.W., and Dekant, W. (2008) Biotransformation of 2,3,3,3-tetrafluoropropene (HFO-1234yf). Toxicol. Appl. Pharmacol. 233, 323-332. (Abstract or full text in PDF)
  10. Han, X*., Yang, C.-H., Snajdr, S.I., Nabb, D.L., and Mingoia, R.T. (2008) Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats. Toxicol. Lett. 181, 81-86. (Abstract or full text in PDF)
  11. Han, X*., Mingoia, R.T., Nabb, D.L., Yang, C.H., Snajdr, S.I., and Hoke, R.A. (2008) Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): Determination of trout hepatocellularity, optimization of cell concentrations and comparision of serum and serum-free incubations. Aquat. Toxicol. 89, 11-17. (Abstract or full text in PDF)
  12. Yang, C., Hasselgren, C.H., Boyer, S., Arvidson, K., Aveston, S., Dierkes, P., Benigni, R., Benz, R.D., Contrera, J., Kruhlak, N.L., Matthews, E.J., Han, X., Jaworska, J., Kemper, R.A., Rathman, J.F., Richard, A.M. (2008) Understanding genetic toxicity through data mining: the process of building knowledge by integrating multiple genetic toxicity databases. Toxicol. Mech. Methods 18, 277-295. (Abstract or full text in PDF) 
  13. Han, X.*, Nabb, D.L., Mingoia, R.T., & Yang, C.H. (2007) Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment. Environ. Sci. Technol. 41, 3269-3276. (Abstract or full text in PDF)
  14. Mingoia, R.T., Nabb, D.L., Yang, C.H., & Han, X.* (2007) Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screenings. Toxicol. In Vitro 21, 165-173. (Abstract or full text in PDF)
  15. Nabb, D.L., Mingoia, R.T., Yang, C.H., & Han, X.* (2006) Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat. Aquat. Toxicol. 80, 52-59. (Abstract or full text in PDF)
  16. Hinderliter, P.M., Han, X., Kennedy, G.L., & Butenhoff, J.L.* (2006) Age effect on perfluorooctanoate (PFOA) plasma concentration in post-weaning rats following oral gavage with ammonium perfluorooctanoate (APFO). Toxicology 225, 195-203. (Abstract or full text in PDF)
  17. Li, Y., Han, X., Lai, A.L., Bushweller, J.H., Cafiso, D.S., & Tamm, L.K.* (2005) Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion. J. Virol. 79, 12065-12076. (Abstract or full text in PDF)
  18. Han, X*., Kemper, R.A., & Jepson, G.W. (2005) Subcellular distribution and protein binding of perfluorooctanoic acid in rat liver and kidney. Drug Chem. Toxicol. 28, 197-209. (Abstract or full text in PDF)
  19. Han, X.*, Hinderliter, P.A., & Jepson, G.W. (2004) Binding of perfluorooctanoic acid to rat liver-form and kidney-form alpha2u-globulins. Drug Chem. Toxicol. 27, 341-360. (Abstract or full text in PDF)
  20. Han, X.*, & Kang, W. (2004) Sequence analysis and membrane partitioning energies of alpha-helical antimicrobial peptides. Bioinformatics 20, 970-973. (Abstract or full text in PDF)
  21. Han, X*., Snow, T.A., Kemper, R.A., & Jepson, G.W. (2003) Binding of perfluorooctanoic acid to rat and human plasma proteins. Chem. Res. Toxicol. 16, 775-781. (Abstract or full text in PDF)
  22. Li, Y., Han, X., & Tamm, L.K. (2003) Thermodynamics of fusion peptide - membrane interactions. Biochemistry 42, 7245-7251. (Abstract or full text in PDF)
  23. Han, X., Bushweller, J. H., Cafiso, D. S. & Tamm, L. K.* (2001) Membrane Structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin. Nature Struct. Biol. 8, 715-720. (Abstract or full text in PDF) (Commentary by F.S. Cohen)
  24. Han, X. & Tamm, L. K.* (2000) A host-guest system to study structure-function relationships of membrane fusion peptide. Proc. Natl. Acad. Sci. USA 79, 13097-13102. (Abstract or full text in PDF)
  25. Han, X. & Tamm, L. K.* (2000) pH dependent self-association of influenza fusion peptide in the lipid bilayers. J. Mol. Biol. 304, 953-965. (Abstract or full text in PDF)
  26. Han, X., Steinhauer, D. A., Wharton, S. A., & Tamm, L. K.* (1999) Interaction of mutant influenza virus hemagglutinin fusion peptides with lipid bilayers: probing the role of hydrophobic residue size in the central region of fusion peptide. Biochemistry 38, 15052-15059. (Abstract or full text in PDF)
  27. Han, X.*, Li, G.-H., Li, G. & Lin, K.-C. (1998) FTIR study of the thermal denaturation of alpha-actinin in its lipid-free and dioleoylphosphatidylglycerol-bound states and the central rod and N-terminal domains of a-actinin in D2O. Biochemistry 37, 10730-10737. (Abstract or full text in PDF)
  28. Han, X., Li, G., Li, G.-H. & Lin, K.-C.* (1997) Interactions between Smooth Muscle alpha-Actinin and Lipid Bilayers. Biochemistry 36 (34), 10364-10371. (Abstract or full text in PDF)
  29. Tamm, L. K.*, & Han, X. (2000) Viral fusion peptides: A tool set to disrupt and connect biological membranes. (Review) Biosciene Reports 20, 501-508 (Abstract or Preview text in PDF).
  30. Tamm, L. K.*, Han, X., Li, Y., & Lai, A.L. (2002) Structure and function of membrane fusion peptides. (Review) Biopolymers 66, 249-260. (Abstract or full text in PDF)
  31. Han, X., Li, G. & Yang, Li. (1998) The effect of sulfoquinovosyldiacylglycerol on the stability of bilayers containing non-bilayer-preferring lipids. Chinese Biochem. & Mol. Biol. 14 (3), 342-349.
  32. Han, X., Li, G., Lin, K., Zhang, X. & Xu, W. (1996) Interactions of a-actinin and membranes- - - studied by the methods of fluorescence energy transfer and electron microscopy. Acta Biophysica Sinica 13, 40-44.
  33. Han, X., Li, G. & Lin, K. (1996) Observations of membrane-bound gramicidin S by a scanning tunneling microscope. Acta Biophysica Sinica 13, 155-160.
  34. Han, X. & Li, G. (1995) Supported bilayer systems on solid substrates. Prog. Biochem. Biophys. (Beijing) 22, 232-236.
  35. Han, X., Zhang, X. & Xing, L. (1995) Two-dimensional crystal of membrane proteins. J. Chinese Electron Microscopy Soc. 14: 440-444.


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