Stephen L. Hajduk

Professor and Head

Department of Biochemistry and

Molecular Biology

University of Georgia

B129 Life Sciences

Athens, Georgia 30602

Phone: 706-542-1676

Fax: 508-457-4727

Email: shajduk@bmb.uga.edu

Education:

1970-1976 University of Georgia, Athens, Georgia. BS, under the direction of Dr.

William B. Cosgrove; Research Activities: Invertebrate hemoglobins and

trypanosome mitochondria

1976-1980 University of Glasgow, Glasgow, Scotland, UK, PhD, under the direction of

Professor Keith Vickerman; Research Activities: Mechanism of antigenic variation in African

trypanosomes

1980-1983 Postdoctoral Fellow, Johns Hopkins University School of Medicine,

Baltimore, MD, under the direction of Dr. Paul T. Englund; Research Activities: Replication 

of the kinetoplast DNA of trypanosomes

Academic Appointments:

1978/1979 Visiting Scholar, University of Amsterdam, Laboratory of Piet Borst

1983-1988 Assistant Professor, Department of Biochemistry, University of Alabama at

    Birmingham, School of Medicine

1988-1991 Associate Professor, Department of Biochemistry, University of Alabama at

    Birmingham, School of Medicine

1994 Fogarty International Scholar, Netherlands Cancer Institute, Amsterdam,

    The Netherlands

1994-1997 Director, Biology of Parasitism, Marine Biological Laboratory, Woods Hole,

1991-2003 Professor, Department of Biochemistry & Molecular Genetics, University of

    Alabama at Birmingham, School of Medicine

1998-2003 Director, Center for Community Outreach Development (CORD), University

    of Alabama at Birmingham

2004-2006 Professor, Department of Molecular Microbiology & Immunology (MMI),

    Brown University

2003-2006 Senior Scientist and Director of the Program in Global Infectious Diseases,

    Josephine Bay Paul Center, Marine Biological Laboratories, Woods Hole,

2006-present Professor and Head, Department of Biochemistry & Molecular Biology,

    University of Georgia

Distinctions:

1975 Presidential Scholarship, Electron Microscopy Society of America

1975 Sigma Xi Undergraduate Research Award, University of Georgia

1976-79 Overseas Development Agency (ODA) Doctoral Fellowship

1977 NATO Visiting Scholar Award (University of Amsterdam: Professor P. Borst)

1979 Royal Society of Tropical Medicine and Hygiene (RSTM&H) Scholarship

1979 EMBO Short-term Fellowship (University of Amsterdam; Professor P. Borst)

1980-83 Rockefeller Foundation Postdoctoral Fellowship

1984 Hutner Young Investigator Award from the Society of Protozoologists

1991 Burroughs Wellcome Fund Scholar in Molecular Parasitology

1995 Organizer RNA Editing Session, RNA Processing Meeting, Cold Spring Harbor

1996 Symposium Organizer, Molecular Parasitology, Am. Soc. Trop. Med. & Hyg.

2000-03 Co-organizer, Molecular Parasitology Meeting, Woods Hole, MA

2002 Odessa Woolfolk Community Service Award, Birmingham AL

2006 Gordon Conf., Host Parasite Interactions, Discussion Leader, “Organelle

    Biogenesis”

2006 International Society of Protistologists, Symposium Organizer, “Protein

    Trafficking”

2007 RNA Society Meeting, Madison Wisconsin, “Editing & Modification”,

    Session Chairman

Other Activities:

1989-1995 Journal of Eukaryotic Microbiology, Board Member, Associate Editor

1989-2002 Experimental Parasitology, Editorial Board

2002-2004 Experimental Parasitology, Editor in Chief

1993-2007 Molecular and Biochemical Parasitology, Editorial Board

1990-1994 National Institutes of Health, Tropical Medicine/Parasitology Study Section

1994-present Ad-hoc reviewer, National Institutes of Health Study Sections

1995-2001 Journal of Biological Chemistry, Editorial Board

1996-2003 Parasitology International, Regional Editor

2000-2003 Howard Hughes Medical Institute, Pre-doctoral Fellowship Committee

2001-2008 Burroughs Wellcome Fund, Pathogenesis, Advisory Panel

2004-2006 Howard Hughes Medical Institute, International Research, Advisory Panel

2007-present Annual Reviews of Microbiology, Editorial Board

Society Memberships: American Association for the Advancement of Science (AAAS),

American Society of Protozoologists, American Society Cell Biology (ASCB), American Society

for Microbiology (ASM), American Society for Parasitology, RNA Society, American Society of

Biological Chemistry and Molecular Biology (ASTMB)

Current Research Projects:

NIH “Lysis of Trypanosomes by Human Haptoglobin Related Protein” 4/1/04-3/31/09

Hajduk (PI) ROI AI39033

Biochemical analysis on the components of the human innate immune system

that prevents infections by certain parasites.

NIH “Mechanism of RNA Editing in Trypanosomes” 6/1/03-5/31/09

Hajduk (PI) RO1 21401 (unpaid extension)

Computational and molecular analysis of the mechanism and function of

alternative mRNA editing in African trypanosomes.

NIH “Mechanism of tRNA Import into Trypanosome Mitochondria” 4/1/05-3/31/10

Hajduk (PI) RO1 AI61356

Identification and validation of the tRNA import pathway in African trypanosomes.

NIH Determining the Mechanism of tRNA Import into Mitochondria” 4/1/07-3/31/09

Hajduk (PI) T32 GM083276

NRSA postdoctoral research fellowship to Melissa Learch.

NIH “Training in Tropical and Emerging Global Disease” 2004-2009

Colley (PI) T32 AI060546

NIH/Fogarty Center “Training grant- Parasitic disease Research” 2007-2012

Docampo (PI) T32 TW007888

University of Georgia Research Foundation (UGARF) 2008-2010

“Development of a high throughput screen for combinatorial trypanostatic and

transmission-blocking drugs for African sleeping sickness”

Hajduk (PI) FID 637

Pending:

Gates Foundation: Grand Challenges/Explorations “Development of a high throughput scree

for combinational trypanostatic and transmission blocking drugs for African sleeping sickness”

(Ochsenreiter, PI; Hajduk, co-PI; Striepen, co-PI) 2009-2011

Gates Foundation: Grand Challenges/Explorations “A new class of antibiotics that inhibit

ribosome biogenesis in African trypanosomes”

(Hajduk, PI; Gerbi, co-PI) 2009-2013

NIH “Mechanism of RNA Editing in Trypanosomes” 2009-2014

Hajduk (PI) RO1 21401

Publications:

1. Hajduk, S.L. (1976) Demonstration of kinetoplast DNA in dyskinetoplastic strains of

Trypanosoma equiperdum. Science 191, 858-859.

2. Hajduk, S.L. and Cosgrove, W.B. (1976) Hemoglobin in an Ophiuroid, Hemipholis elongata.

American Zoologist 15, 808.

3. Hajduk, S.L. (1976) Tube-foot ultrastructure of an Ophiuroid echinoderm. Proceedings of

the Electron Microscopy Society of America 33, 684-685.

4. Hajduk, S.L. (1978) Influence of DNA complexing compounds on the kinetoplast of

trypanosomatids. In: Progress in Molecular and Subcellular Biology (Hahn, F.E., ed.), Vol.

6, Springer Verlag, Heidelberg, pp. 158-200.

5. Hajduk, S.L. (1979) Dyskinetoplasty in two species of trypanosomatids. J. Cell Sci. 35,

185-202.

6. Hajduk, S.L. and Cosgrove, W.B. (1979) DNA from normal and dyskinetoplastic strains of

Trypanosoma equiperdum. Biochim. Biophys. Acta 561, 1-9.

7. Barry, J.D., Hajduk, S.L., Vickerman, K. and LeRay, D. (1979) Detection of multiple variable

antigen types in metacyclic populations of Trypanosoma brucei. Trans. Roy. Soc. Trop.

Med. Hyg. 73, 205-208.

8. Cosgrove, W.B., Skeen, M.J. and Hajduk, S.L. (1979) Effects of hydroxyurea on Crithidia

fasciculata. J. Protozool. 26, 643-648.

9. Barry, J.D. and Hajduk, S.L. (1979) Antigenic heterogeneity of bloodstream and metacyclic

forms of Trypanosoma brucei. In: Pathogenicity of Trypanosomes (Lasos, G. and

Chouinard, A., eds.) pp. 51-57.

10. Frasch, A.C.C., Hajduk, S.L., Hoeijmakers, J.H.J., Borst, P., Brunnel, F. and Davidson, J.

(1980) The kinetoplast DNA of Trypanosoma equiperdum. Biochim. Biophys. Acta 607,

397-410.

11. Cosgrove, W.B. and Hajduk, S.L. (1980) The effect of environmental oxygen concentration

on the rate of oxygen consumption of the polychaete Sthenllais boa. (Johnston). Cahiers de

Biologie Marine 21, 123-133.

12. Vickerman, K., Barry, J.D., Hajduk, S.L. and Tetley, L. (1980) Antigenic variation in

trypanosomes. In: The Host-Invader Interplay (Van den Bossche, H., ed.), Elsevier/North-

Holland Biomedical Press, Amsterdam, pp. 179-190.

13. Englund, P.T., Hajduk, S.L., Marini, J.C. and Plunkett, M.L. (1981) The replication of

kinetoplast DNA. In: Mitochondrial genes (Slonimski, P., Borst, P. and Attardi, G., eds.),

Cold Spring Harbor Laboratories, New York pp. 423-433.

14. Hajduk, S.L. and Vickerman, K. (1981) Antigenic differentiation of Trypanosoma brucei.

Studies in metacyclic and first parasitaemia populations. Trans. Roy. Soc. Trop. Med. Hyg.

75, 145-146.

15. Hajduk, S.L., Cameron, C., Barry, J.D. and Vickerman, K. (1981) Antigenic analysis of

cyclically-transmitted Trypanosoma brucei. I. Composition of the metacyclic populations.

Parasitology 83, 595-607.

16. Hajduk, S.L. and Vickerman, K. (1981) Antigenic analysis of cyclically-transmitted

Trypanosoma brucei. II. Composition of the metacyclic populations. Parasitology 83, 609-

621.

17. Hajduk, S.L. and Vickerman, K. (1981) Characterization of changes in Trypanosoma brucei

leading to loss of infectivity for the insect vector (Glossina morsitans). Molecular and

Biochemical Parasitology 4, 17-28.

18. Borst, P., Hoeijmakers, J.H.J. and Hajduk, S.L. (1981) Structure, function, and evolution of

kinetoplast DNA. Parasitology 82, 181-192.

19. Crowe, J.S., Barry, J.D., Hajduk, S.L. and Vickerman, K. (1982) Monoclonal antibodies

against variable antigen types of metacyclic Trypanosoma brucei. Trans. Roy. Soc.

Trop. Med. Hyg. 75, 894-895.

20. Gray, G.D., Jennings, F.W. and Hajduk, S.L. (1982) Relapse of monomorphic and

pleomorphic Trypanosoma brucei infections in the mouse after chemotherapy Z.

Parasitenkd. 67, 137-145.

21. Englund, P.T., Hajduk, S.L. and Marini, J.C. (1982) Molecular biology of trypanosomes.

Ann. Rev. Biochem. 51, 695-726.

22. Hajduk, S.L., Englund, P.T., Mahmoud, A.A.F. and Warren, K.S. (1983) In: Tropical

Medicine: African Trypanosomiasis (K.S. Warren and A.A.F. Mahmoud, eds.), MacGraw-

Hill, Inc. pp. 244-252.

23. Hajduk, S.L. (1984) Antigenic variation during the developmental cycle of Trypanosoma

brucei. J. Protozool. 31, 41-47.

24. Hajduk, S.L., Klein, V. and Englund, P.T. (1984) Replication of kinetoplast DNA maxicircles.

Cell 36, 483-492.

25. Ntambi, J., Bangs, J., Hajduk, S.L., Jiminez, H., Klein, V.A., Ryan, K.and Englund, P.T.

(1984) A bent helix is found in fragments of kinetoplast DNA minicircles from several

trypanosomatid species. Molec. Biochem. Parasitol. 12, 273-284.

26. Hajduk, S.L. and Englund, P.T. (1985) Replication of kinetoplast DNA. In: Proceedings of

the Third John Jacob Able Symposium on Molecular Parasitology (J.T. August, ed.),

Academic Press, pp. 53-62.

27. Hajduk, S.L., Kitchin, P., Marini, J.C. and Englund, P.T. (1985) The structure and replication

of kinetoplast DNA. In: Proceedings of UCLA Symposium on Molecular Biology of Host-

Parasite Interactions (N. Agabian and H. Eisen, eds.), Cold Spring Harbor Press, pp. 197-

201.

28. Silver, L.E., Torri, A.F. and Hajduk, S.L. (1986) Organized packaging of kinetoplast DNA

networks. Cell 47, 537-543.

29. Hajduk, S.L., Sigueira, M. and Vickerman, K. (1986) The kinetoplast DNA of Bodo

caudatus: A non-catenated structure. Mol. Cell Biol. 6, 4372-4378.

30. Michelotti, E.F. and Hajduk, S.L. (1987) Developmental regulation of trypanosome

mitochrondrial gene expression. J. Biol. Chem. 262, 927-932.

31. Rohrer, S.P., Michelotti, E.F., Torri, A.F. and Hajduk, S.L. (1987) Transcription of

kinetoplast DNA minicircles. Cell 49, 625-632.

32. Hajduk, S.L., Michelotti, E.F., Rohrer, S.P. and Torri, A.F. (1988) Developmental control of

a subspecies of human high-density lipoprotein toxic to Trypanosoma brucei. In: Molecular

Biology of Protozoan Parasites, (M.J. Turner, ed.), Cold Spring Harbor Press, pp. 122-127.

33. Hajduk, S.L., Moore, D.R., Torri, A.F., Tytler, E.M. and Esko, J.D. (1988) Purification of a

subspecies of human high-density lipoprotein toxic to Trypanosoma brucei. In: Molecular

Biology of Protozoan Parasites, (M.J. Turner, ed.), Cold Spring Harbor Press, pp. 167-170.

34. Hajduk, S.L., Englund, P.T. and Smith, D.H. (1989) In: Tropical and Geographical

Medicine, Second Edition; Chapter 32, African Trypanosomiasis (K.S. Warren and A.A.F.

Mahmoud, eds.), MacGraw-Hill, Inc.

35. Torri, A.F. and Hajduk, S.L. (1988) Cytochrome c expression in Trypanosoma brucei.

Molec. Cell Biol. 8, 4625-4633.

36. Hajduk, S.L., Moore, D.R., Torri A.F., Sigueirra, H., Tytler, E.M. and Esko, J.D. (1989) Lysis

of Trypanosoma brucei by a toxic subspecies of human high density liproprotein J. Biol.

Chem. 264, 5210-5217.

37. Harris, M.E., Moore, D.R. and Hajduk, S.L. (1990) Addition of uridines to edited RNAs in

trypanosome mitochrondria occurs independently of transcription. J. Biol. Chem. 265,

11368-11376.

38. Pollard, V., Rohrer, S.P., Michelotti, E.F., Hancock, K. and Hajduk, S.L. (1990) Organization

of minicircle genes for guide RNAs in Trypanosoma brucei. Cell 63, 783-790.

39. Hancock, K. and Hajduk, S.L. (1990) Mitochondrial tRNAs are nuclear encoded in

Trypanosoma brucei. J. Biol. Chem. 265, 19208-19215.

40. Pollard, V. and Hajduk, S.L. (1990) Trypanosoma equiperdum minicircles encode three

distinct primary transcripts which exhibit guide RNA characteristics. Molec. Cell Biol. 11,

1668-1675.

41. Adler, B.K., Harris, M.E., Bertrand, K.I. and Hajduk, S.L. (1991) Modification of

Trypanosoma brucei mitochondrial rRNA by posttranscriptional 3' polyuridine tail formation.

Molec. Cell Biol. 11, 5878-5884.

42. Hajduk, S.L. (1992) Ultrastructure of the tube-foot ophiuroid echinoderm, Hemiholis

elongata. Tissue & Cell 24, 111-120.

43. Hajduk, S.L., Hager, K. and Esko, J.D. (1992) High-density lipoprotein mediated lysis of

trypanosomes. Parasitology Today 8, 95-98.

44. Harris, M.E. and Hajduk, S.L. (1992) Kinetoplastid RNA editing: In vitro formation of

cytochrome b gRNA/mRNA chimeras from synthetic substrate RNAs. Cell 68, 1091-1100.

45. Harris, M.E., Decker, C., Sollner-Webb, B. and Hajduk, S.L. (1992) Specific cleavage of

pre-edited mRNAs in trypanosome mitochondrial extracts. Molec. Cell Biol. 12, 2591-2598.

46. Michelotti, E.F., Harris, M.E., Adler, B.K., Torri, A.F. and Hajduk, S.L. (1992) Mitochondrial

ribosomal RNA synthesis, processing and developmentally regulated expression in

Trypanosoma brucei. Molec. Biochem. Parasitol. 54, 31-42.

47. Hancock, K. and Hajduk, S.L. (1992) Sequence of Trypanosoma brucei tRNA genes

encoding cytosolic tRNAs. Nucl. Acids Res. 20, 2602.

48. Priest J. and Hajduk, S.L. (1992) Cytochrome c reductase purified from Crithidia fasciculata

contains an atypical cytochrome c1. J. Biol. Chem. 267, 20188-20195.

49. Pollard, V., Harris, M.E. and Hajduk, S.L. (1992) RNA editing complexes from Trypanosoma

brucei mitochrondria. EMBO J. 12, 4429-4438.

50. Hancock, K., LeBlanc, A., Donze, D. and Hajduk, S.L. (1992) Identification of precursor

tRNAs within the mitochondrion of Trypanosoma brucei. J. Biol Chem. 267, 23963-23971.

51. K.I., Fearon, K., Hager, K.M., Hancock, K., Harris, M., LeBlanc, A.J., Moore, R., Pollard, V.,

Priest, J.W. and Wood, Z. (1992) Molecular biology of African Trypanosomes:

Development of new strategies to combat an old disease. Am. J. Med. Sci. 303, 258-269.

52. Hajduk, S.L., Harris, M.E. and Pollard, V. (1993) RNA editing in kinetoplastid mitochondria.

FASEB J. 7, 54-63.

53. Torri, A.F., Bertrand, K.I. and Hajduk, S.L. (1993) Protein stability regulates the expression

of cytochrome c during the developmental cycle of Trypanosoma brucei. Molec. Biochem.

Parasitol. 57, 305-316.

54. Priest, J.W., Wood, Z.C. and Hajduk, S.L. (1993) Apocytochrome c1 of kinetoplastid

protozoa lack mitochondrial targeting presequences. Biochemica Biophysica Acta 1144,

229-231.

55. Hager, K., Pierce, M.A., Moore, D.R., Tytler, E.M., Esko, J.D. and Hajduk, S.L. (1994) Lysis

of Trypanosoma brucei by a toxic subspecies of human high density lipoprotein requires

receptor mediated endocytosis. J. Cell Biol. 126, 155-167.

56. Hajduk, S.L., Adler, B.K., Bertrand, Pollard, V.W., Sabatini, R. and Hajduk, S.L. (1994)

Molecular and biochemical methods for the analysis of kinetoplastid RNA editing. Methods

in Molecular Genetics 3, 61-87.

57. Priest, J.W. and Hajduk, S.L. (1994) Developmental regulation of mitochondrial biogenesis

in Trypanosoma brucei. J. Bioenerg. Biomemb. 26, 179-191.

58. Hajduk, S.L., Hager, K.M. and Esko, J.D. (1994) Killing of African Trypanosomes in human

high density lipoproteins. Annual Reviews of Microbiology 48, 139-162.

59. Adler, B.K. and Hajduk, S.L. (1994) Mechanisms and origins of RNA editing. Current Opin.

Genet. Dev. 4, 316.

60. Priest, J.M. and Hajduk, S.L. (1994) Developmental regulation of cytochrome c reductase

complex assembly in trypanosome mitochondria. Molec. Biochem. Parasitol. 65, 291-304.

61. Sabatini, R. and Hajduk, S.L. (1995) RNA editing. Posttranscriptional restructuring of

genetic information. In: Molecular Biology of Parasitic Protozoa. (Parsons and Smith, eds.),

Oxford University Press.

62. Hajduk, S.L., Smith, A.B. and Hager, K.M. (1995) HDL-independent lysis of Trypanosoma

brucei by human serum: A comment. Parasitology Today.

63. Tytler, E.M., Moore, D.R., Pierce, M.A., Hager, K.M., Esko, J.D. and Hajduk, S.L. (1995)

Reconstitution of the Trypanosome Lytic Factor. The role of lipids and apoliproteins in the

cytoxicity of a subspecies of human high-density lipoproteins toxic to Trypanosoma brucei.

Molec. Biochem. Parasitol. 69, 9-17.

64. Sabatini, R. and Hajduk, S.L. (1995) RNA ligase and its involvement in guide RNA/mRNA

chimera formation: Evidence for cleavage-ligation type mechanism of Trypanosoma brucei

mRNA editing. J. Biol. Chem. 270, 7233-7240.

65. Smith, A.B., Esko, J.D. and Hajduk, S.L. (1995) Killing of trypanosomes by haptoglobinrelated

protein. Science 268, 284-286.

66. Moore, D.R., Smith, A., Hager, K.M., Waldon, R., Esko, J.D. and Hajduk, S.L. (1995)

Developmentally regulated sensitivity of Trypanosoma brucei to cytotoxic effects of human

high density lipoprotein. Expt. Parasitol. 81, 216-226.

67. Piller, K.J., Decker, C.J., Harris, M.E., Hajduk, S.L. and Sollner-Webb, B. (1995) Editing

domains of Trypanosoma brucei mitochondrial RNAs identified by secondary structure.

Molec. Cell Biol. 15, 2916-1924.

68. Smith, A.B., and Hajduk, S.L. (1995) Identification of haptoglobin as a natural inhibitor of

trypanocidal activity in human serum. Proc. Natl. Acad. Sci. USA 92, 10262-20266.

69. Priest, J.W. and Hajduk, S.L. (1995) The trypanosomatid Rieske iron-sulfur proteins have a

cleaved presequence that may direct mitochondrial import. Biochim. Biophys. Acta 1269,

201-204.

70. Priest, J.W. and Hajduk, S.L. (1996) In vitro import of the Rieske iron-sulfur protein by

trypanosome mitochrondria. J. Biol. Chem. 271, 20060-20069.

71. Zhang, Z., Kang, S-M., LeBlanc, A., Hajduk, S.L. and C.D. Morrow (1996) Nucleotide

sequences within the U5 region of the viral RNA genome are the major determinants for

human immunodeficiency virus type 1 to maintain a primer binding site complementary to

tRNA His. Virology 226, 306-317.

72. Hager, K.M. and Hajduk, S.L. (1997) Mechanism of resistance of human sleeping sickness

trypanosomes to cytotoxic human HDL. Nature 385, 823-826.

73. Adler, B.K. and Hajduk, S.L. (1997) Editing site specific endonuclease cleavage of unedited

cytochrome b mRNA requires the formation of a guide RNA/mRNA complex. Molec. Cell

Biol. 17, 5377-5385.

74. Antenucci, S.M., Sabatini, R.S., Pollard, V.M. and Hajduk, S.L. (1998) Kinetoplastid RNA

editing associated with protein 1 (REAP 1): A novel editing complex protein with repetitive

domains. EMBO J. 17, 6368-6376.

75. Hajduk, S.L., and Sabatini, R.S. (1998) Mitochondrial mRNA editing in Kinetoplastid

protozoa. pp. 377-394. In: Modification and Editing of RNA (Henri Grosjean & Rob Benne,

eds) ASM Press, Washington D.C.

76. Sabatini, R.S., Adler, B.K., Madison-Antenucci, S., McManus, M.T. and Hajduk, S.L. (1998)

Biochemical methods for the analysis of kinetoplastid RNA editing. In: Methods: A

companion to Methods in Enzymology, (Chan, L., ed.) Academic Press, Inc., New York,

USA

77. Yermovsky-Kammerer, A.E. and Hajduk, S.L. (1999) Import of nuclear encoded tRNA into

mitochondria. In; The Biology of Parasitism. (E. Pearce & C. Tschudi, eds) MBL Lectures in

Biology.

78. Milner, J.D. and Hajduk, S.L. (1999) Expression and localization of a serum resistance

associated protein in Trypanosoma brucei rhodesiense. Molec. Biochem. Parasitol. 104,

271-283.

79. Yermovsky-Kammerer, A. E. and Hajduk, S.L. (1999) In vitro import of a nuclear encoded

tRNA into the mitochondrion of Trypanosoma brucei. Molec. Cell Biol. 19, 6253-6259.

80. LeBlanc, A.J. Yermovsky-Kammerer, A., and Hajduk, S.L. (1999) A nuclear encoded and

mitochondrial imported dicistronic tRNA precursor in Trypanosoma brucei. J. Biol. Chem.

274, 21071-21077.

81. McManus, M.T., Adler, B.K., Pollard, V.W. and Hajduk, S.L. (2000) Trypanosoma brucei

gRNA poly(U) tail formation is stabilized by cognate mRNA. Molec. Cell. Biol. 20, 883-891.

82. Bertrand, K.I. and Hajduk, S.L. (2000) Import of a constitutively expressed protein into

mitochondria from procyclic and bloodstream forms of Trypanosoma brucei. Molec.

Biochem. Parasitol. 106, 249-260.

83. Grams, J., McManus, M. and Hajduk, S.L. (2000) Processing of polycistronic guide RNAs is

associated with RNA editing complexes in Trypanosoma brucei. EMBO J. 19, 5525-5532.

84. McManus, M., Shimura, M., Grams, J. and Hajduk, S.L. (2001) Identification of candidate

mitochondrial RNA editing ligases from Trypanosoma brucei. RNA 7, 167-175.

85. Madison-Antenucci, S. and Hajduk, S.L. (2001) RNA editing associated protein-1 binds preedited

mRNA. Molec. Cell 7, 879-886.

86. Shimamura, M., Hager, K.M., and Hajduk, S.L. (2001) The lysosomal targeting and

intracellular metabolism of trypanosome lytic factor by Trypanosoma brucei brucei. Molec.

Biochem. Parasitol. 115, 227-237.

87. Drain, J., Bishop, J. and Hajduk, S.L. (2001) Haptoglobin related protein mediates

trypanosome lytic factor binding to trypanosomes. J. Biol. Chem. 276, 30254-30260.

88. Barker, C., Barbour, K.W., Berger, F.G. and Hajduk, S.L. (2001) Activity of human

trypanosome lytic factor-1 in mice. Molec. Biochem. Parasitol. 117, 129-136.

89. Bishop, J. R., Shimamura, M., and Hajduk, S.L. (2001) Insight into the mechanism of human

serum killing of African trypanosomes. Molec. Biochem. Parasitol. 118, 33-40.

90. Hatada, S., Seed, J.R., C. Barker, Hajduk, S.L., Black, S.J. and Maeda, N. (2002) No

trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein.

Molec. Biochem. Parasitol. 119, 291-294.

91. Madison-Antenucci, S., Grams, J., and S.L. Hajduk (2002) Editing Machines: The

Complexities of Trypanosome RNA Editing. Cell 108, 435-438.

92. Grams, J., Morris, J.C., Drew, M.E., Wang, Z., Englund, P.T., and S.L. Hajduk (2002)

Transcription and Priming Replication of Kinetoplast DNA Maxicircles by a Mitochondrial

RNA Polymerase. J. Biol. Chem. 277, 16952-16959.

93. Priest, J.W. and Hajduk, S.L. (2003) Trypanosoma brucei cytochrome c1 is imported into

mitochondria along an unusual pathway. J. Biol. Chem. 278, 15084-15094.

94. Imrie, H., Ferguson, D., Carter, M., Drain, J., Shiflett, A., Hajduk, S.L. and Day, K. (2004)

Killing of Plasmodium falciparum by human haptoglobin related protein. Parasitology 128,

577-584..

95. Sherrer, R.A., Yermovsky-Kammerer, A., and Hajduk, S.L. (2003) A sequence motif within

trypanosome precursor tRNAs influences abundance and mitochondrial localization. Molec.

Cell. Biol. 23, 9061-9072.

96. Wood, Z.A., Sabatini, R.S., and Hajduk, S.L. (2004) RNA Ligase: Picking up the Pieces.

Molecular Cell 13, 1-2.

97. Golden, D.E. and Hajduk, S.L. (2005) The 3′ untranslated region of cytochrome oxidase II

mRNA functions in RNA editing of African trypanosomes exclusively as a cis guide RNA.

RNA 11, 29-37.

98. Shiflett, A.M., Bishop, J.R., Pahwa, A. and Hajduk, S.L. (2005) Human HDLs are multicomponent

innate immune complexes. J Biol Chem. 280, 32578-85.

99. Oli MW, Cotlin LF, Shiflett AM, Hajduk, SL. (2006) Serum resistance-associated protein

blocks lysosomal targeting of trypanosome lytic factor in Trypanosoma brucei. Eukaryot

Cell. 5,132-9.

100. Golden D.E. and Hajduk, S.L. (2006) The importance of RNA structure in RNA editing and

a potential proofreading mechanism for correct guide RNA:pre-mRNA binary complex

formation. J. Molec. Biol. 359, 585-596.

101. Faulkner, S.D., Oli, M.W., Kieft, R., Cotlin, L., Widener, J., Shiflett, A., Cipriano, M.J.,

Pacocha, S.E., Birkeland, S.R., Hajduk, S.L., and McArthur, A.G. (2006) In vitro

generation of human HDL resistant Trypanosoma brucei brucei. Eukaryot. Cell 5, 1276-

1286.

102. Ochsenreiter, T. and Hajduk, S.L. (2006) Alternative editing of mRNA generates protein

diversity. EMBO Reports 7, 1128-1133.

103. Hajduk, S.L. (2006) Perspective: Timing sexual development of parasites. Science 313,

626-627.

104. Shiflett, A.M. Faulkner, S.D., Cotlin, L.F., Widener, J., Stephens, N., and Hajduk, S.L.

2007. African Trypanosomes: Intracellular Trafficking of Host Defense Molecules.

Eukaryot. Microb. 54, 18-21.

105. Ochsenreiter, T. Cipriano, M. and Hajduk, S.L. (2007) KISS: The Kinetoplastid Editing

Sequence Search Tool. RNA 13, 1-4.

106. Ochsenreiter, T. and Hajduk, S.L. (2007) The Function of RNA Editing in Trypanosomes.

In: RNA Editing (Goringer, U., ed.), Springer Verlag Press.

107. Widener, J., Nielsen, M., Shiflett, A. Moestrup, S. and Hajduk S. (2007) Hemoglobin is a

co-factor for trypanosome lytic factor. PLoS Pathogens 3, 1250-1261

108. Hans, J., Marchewka, M., Hajduk, S.L. and S. Madison-Antenucci (2007) Role of RNAEditing

Associate Protein-1: Null mutants reveal link to mitochondrial RNA stability. RNA

13, 881-889.

109. Ekanayake, D.K., Mark Welch, D., Kieft, R., Hajduk, S.L. and Dittus, W.P.J. (2007)

Transmission dynamics of Cryptosporidium infection of a natural population of non-human

primates at Polonnaruwa, Sir Lanka. Am. J. Trop. Med. Hyg. 77, 818-822.

110. Ochsenreiter, T., Cipriano, C., and Hajduk, S.L. (2008) Alternative mRNA Editing in

Trypanosomes Is Extensive and May Contribute to Mitochondrial Protein Diversity. PLoS

One 3, e1566.

111. Peck, R.F., Shiflett, A.M., Hajduk, S.L., and J. D. Bangs (2008) The LAMP-like protein p67

plays an essential role in the lysosome of African trypanosomes (submitted for publication)

112. Ochsenreiter, T., Anderson, S., Wood Z.A. and Hajduk S.L. (2008) Alternative RNA editing

produces a novel protein involved in mitochondrial DNA maintenance in trypanosomes.

Molec. Cell. Biol. (in press)

113. Shiflett, A.M. Faulkner, S.D., Cotlin, L.F., Widener, J., Stephens, N., and Hajduk, S.L.

(2008) Trypanosoma brucei brucei killing by human serum results from lysosomal

membrane breakdown. (in preparation)

114. Sherrer, R.L., Lerch, M.L. and Hajduk, S.L. (2008) Transcription of tRNAs in

trypanosomes is dependent on a conserved upstream sequence motif. (in preparation).

Recent Scientific Presentations (2006-present)

Louisiana State University, Department of Biochemistry, Invited Speaker (2006).

University of Alabama Birmingham, Department of Biochemistry & Molecular Genetics,

Symposium Speaker (2007).

University of Alabama at Birmingham, Center for Community Outreach and Development,

Invited Speaker (2007).

Denver Public Schools, Invited Speaker (2006).

Gordon Research Conference, RNA Editing, Ventura CA, Invited Speaker (2007).

RNA Society Meeting, Session Organizer, Madison WI (2007).

Oklahoma University Health Center, Department of Biochemistry, Invited Speaker (2006).

University of Georgia, Infectious Disease Department, Invited Speaker (2006).

New York University School of Medicine, Department of Parasitology, Invited Speaker (2007).

Clemson University, Department of Biology, Invited Speaker (2007).

International Congress of Protistologist, Lisbon, Portugal, Invited Speaker; (2007).

Georgia Tech, Department of Biology, Invited Speaker (2007).

University of New York, Albany and the Wadsworth Institute, Invited speaker (2008).

University of Tennessee, Department of Microbiology, Invited speaker (2008).

American Society of Tropical Medicine, Symposium Speaker (2008).

Biology of Parasitism, MBL, Speaker (2008)

University of Alabama at Birmingham, BioTeach, Invited Speaker (2008).

Meherry School of Medicine, Invited Speaker (2008).

University of Pennsylvania, Department of Pathobiology, Invited Speaker (2008).

Editorial Boards and Advisory Panels (2006-present)

Molecular and Biochemical Parasitology, Editorial Board Member

Public Library of Science (PLoS) Pathogens, Associate Editor

Annual Reviews in Microbiology, Editorial Board Member

Wellcome Trust, Advisory Group

Burroughs Wellcome Fund, Advisory Panel in Molecular Pathogenesis (Panel Chairperson)

Ad hoc reviewer: Science, Nature, Molecular Cell, Eukaryotic Cell, Journal of Biological

Chemistry, Journal of Experimental Medicine, EMBO J., Current Biology, Cell

Ad hoc reviewer: National Institutes of Health, German Federal Ministry of Education and

Research

Student Committees (2006-present)

April Shiflett, Pathobiology Program, Brown University

Justin Widener, Pathobiology Program, Brown University

Natalie Stephens, Biochemistry and Molecular Biology Program, University of Georgia

Sarah Reiff, Cell Biology Program, University of Georgia

Shanda Birkeland, Biochemistry and Molecular Biology Program, University of Georgia

Steven Sykes, Cell Biology Program, University of Georgia

Teaching Activities (2006-07)

University of Georgia, Biology of Parasitism (1 lecture; 16 students)

University of Georgia, BCMB3100 (10 lectures; 65 students)

University of Georgia, BCMB8030 (15 lectures; 11 students)

University of Alabama at Birmingham, BioTeach, (1 lecture; 20 students)

University of Georgia, Freshman Seminar (FRES 1020) (12 lectures; 16 students)

University of Georgia, Undergraduate Research -

Khyati Chudasama (2006-2007)

Sawyer Howell (2007-2008)

Thomas Johnson (2008-present)

Nichole Costa (2008-present)

Hailey Myung (2008-present)

University of Georgia, Graduate Research -

Natalie Stephens

Steven Sykes

David Seidman

Summer Undergraduate Research Fellow (REU) National Science Foundation-

Justin Graham (2007)

Keri Jamison (2008)

Jasmyn Virgo (2008)