Welcome to the Gutiérrez Medina Lab at IPICYT in San Luis Potosí, México. The goal of our lab is to study the biophysics of cellular and molecular systems in complex environments using the tools of biophotonics. Current work includes: uncovering mechanisms in the motor protein kinesin and in DNA-protein interactions at the single-molecule level, understanding the role of environmental factors in protein aggregation, and developing novel methods in optical microscopy.

People

Principal investigator

Braulio Gutiérrez-Medina

Ph.D. in Physics, UT Austin, 2004

Postdoctoral researchers

Alecis Vázquez Villa

Ph.D. in Optics, INAOE, México, 2015

Alejandra Gutiérrez Esparza

Ph.D. in Physics, University of Guanajuato, México, 2014

Graduate students

Gamaliel Sánchez Orellana

Ph.D. in Nanosciences and Materials

Publications

B. Gutiérrez-Medina, A. Vázquez Villa. “Mechanical interaction between hyphae during three-dimensional growth,” Fungal Genetics and Biology 151:103563 (2021).

B. Gutiérrez-Medina, A. Vázquez Villa. “Visualizing three-dimensional fungal growth using light sheet fluorescence microscopy,” Fungal Genetics and Biology 150:103549 (2021).

B. Gutiérrez-Medina, C.N. Hernández Candia. “Aggregation kinetics of the protein photoreceptor Vivid,” Biochim. Biophys. Acta - Proteins and Proteomics 1869:140620 (2021).

G. Sánchez-Orellana, S. Casas-Flores, B. Gutiérrez-Medina. “Automated, continuous video microscopy tracking of hyphal growth,” Fungal Genetics and Biology 123:25-32 (2019).

B. Gutiérrez-Medina, M. Buendía Padilla, A.R. Oaxaca Camacho, A.J. Gutiérrez Esparza. “Differential effect of multiple kinesin motors on run length, force and microtubule binding rate,” Biophysical Chemistry 242:28-33 (2018).

C.N. Hernández Candia, S. Casas-Flores, B. Gutiérrez-Medina. “Light induces oxidative damage and protein stability in the fungal photoreceptor Vivid,” PLoS ONE 13(7), e0201028 (2018).

B. Gutiérrez-Medina, M.J. Sánchez Miranda. “Quantitative image restoration in bright field optical microscopy,” Biophysical Journal 113:1916-1919 (2017).

M. Osorio-Concepción, G.R. Cristóbal-Mondragón, B. Gutiérrez-Medina, S. Casas-Flores. “Histone Deacetylase HDA-2 Regulates Trichoderma atroviride Growth, Conidiation, Blue Light Perception, and Oxidative Stress Responses,” Appl Environ Microbiol 83:e02922-16 (2017).

M. Guzmán-Altamirano, B. Gutiérrez-Medina. “Removing lateral chromatic aberration in bright field optical microscopy,” Optics Express 23(11),14380-14390 (2015).

J.S. Murguía, H.C. Rosu, A. Jiménez, B. Gutiérrez-Medina, J.V. García-Meza. “The Hurst exponents of Nitzschia sp. diatom trajectories observed by light microscopy,” Physica A 417,176-184 (2015).

B. Gutiérrez-Medina, A. Jiménez Guerra, A.I. Peña Maldonado, Y. Covarrubias Rubio, J. V. García Meza. “Circular random motion in diatom gliding under isotropic conditions,” Physical Biology 11, 066006 (2014).

N.A. Gerling Cervantes, B. Gutiérrez-Medina. “Robust Deposition of Lambda DNA on Mica for Imaging by AFM in Air,” Scanning 36, 561-569 (2014).

C.N. Hernández Candia, B. Gutiérrez-Medina. “Direct Imaging of Phase Objects Enables Conventional Deconvolution in Bright Field Light Microscopy,” PLoS ONE 9(2), e89106 (2014).

C.N. Hernández Candia, S. Tafoya Martínez, B. Gutiérrez-Medina. “A minimal optical trapping and imaging microscopy system,” PLoS ONE 8(2), e57383 (2013).

B. Gutiérrez-Medina “Wave transmission through periodic, quasiperiodic, and random one-dimensional finite lattices,” American Journal of Physics 81, 104-111 (2013).

B. Gutiérrez-Medina and S. M. Block. “Visualizing individual microtubules by bright field microscopy,” American Journal of Physics 78. 1152-1159 (2010).

B. Gutiérrez-Medina, J. O. Andreasson, W. J. Greenleaf, A. LaPorta, and S. M. Block. “An optical apparatus for rotation and trapping,” Methods in Enzymology 475, 377-404 (2010).

B. Gutiérrez-Medina, A. N Fehr, and S. M. Block. “Direct measurements of kinesin torsional properties reveal flexible domains and occasional stalk reversals during stepping,” PNAS 106, 17007-17012 (2009).

A. N Fehr, B. Gutiérrez-Medina, C. L. Asbury, and S. M. Block. “On the origin of kinesin limping,” Biophysical Journal 97, 1663-1670 (2009).

M. T. Valentine, N. R. Guydosh, B. Gutiérrez-Medina, A. N. Fehr, J. O. Andreasson, and S. M. Block. “Precision steering of an optical trap by electro-optic deflection,” Optics Letters 33, 599-601 (2008).

K. Henderson, H. Kelkar, T. C. Li, B. Gutiérrez-Medina, and M. G. Raizen. “A Bose-Einstein condensate driven by a kicked rotor in a finite box,” Europhys. Lett. 75, 392-398 (2006).

K. Henderson, H. Kelkar, B. Gutiérrez-Medina, T. C. Li, and M. G. Raizen. “Experimental Study of the Role of Atomic Interactions on Quantum Transport,” Phys. Rev. Lett. 96, 150401 (2006).

B. Gutiérrez-Medina, M. C. Fischer, and M. G. Raizen. “Observation of the Quantum Zeno and Anti-Zeno Effects in an Unstable System,’’ Proceedings of the XXII Solvay Conference in Physics: The Physics of Communication (World Scientific, Singapore, 2003), p.219.

M. C. Fischer, A. M. Dudarev, B. Gutiérrez-Medina, and M. G. Raizen. “FM spectroscopy in recoil-induced resonances,” J. Opt. B: Quantum Semiclass. Opt. 3, 279-287 (2001).

M. C. Fischer, B. Gutiérrez-Medina, and M. G. Raizen. “Observation of the Quantum Zeno and Anti-Zeno Effects in an Unstable System,” Phys. Rev. Lett. 87, 040402 (2001).