Publications
2012 47. Hart, M.P. and A.D. Gitler, ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications. J Neurosci, 2012. In press.46. Hart, M.P., J. Brettschneider, V.M. Lee, J.Q. Trojanowski, A.D. Gitler, Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions. Acta Neuropathol, 2012. April 21. pdf 45. Couthouis, J., M.P. Hart, R. Erion, Z. Diaz, T. Nakaya, F. Ibrahim, H.J. Kim, J. Mojsilovic-Petrovic, D. Clay-Falcone, L. Elman, L. McCluskey, R. Greene, R.G. Kalb, V.M. Lee, J.Q. Trojanowski, G.A. Nicholson, I.P. Blair, O.D. King, N.M. Bonini, V.M. Van Deerlin, Z. Mourelatos, J. Shorter, A.D. Gitler, Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Mol Genet, 2012, Mar 27. pdf 44. Chesi, A., A. Kilaru, X. Fang, A.A. Cooper, A.D. Gitler, The Role of the Parkinson's Disease Gene PARK9 in Essential Cellular Pathways and the Manganese Homeostasis Network in Yeast. PLoS One, 2012. 7(3): e34178. pdf 43. King O.D.*, A.D. Gitler*, J. Shorter*, The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Res, 2012. Jan 20. *Co-corresponding authors. pdf 42. Gispert S., A. Kurz, S. Waibel, P. Bauer, I. Liepelt, C. Geisen, A.D. Gitler, T. Becker, M. Weber, D. Berg, P.M. Andersen, R. Krüger, O. Riess, A.C. Ludolph, G. Auburger, The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect. Neurobiol Dis, 2012. 45(1):356-361. pdf 2011 41. Couthouis, J.*, M.P. Hart*, J. Shorter*, M. DeJesus-Hernandez, R. Erion, R.E. Oristano, X.A. Liu, D. Ramos, N. Jethava, D. Hosangadi, J. Epstein, A. Chiang, Z. Diaz, T. Nakaya, F. Ibrahim , H.J. Kim, J.A. Solski, K.L. Williams, J. Mojsilovic-Petrovic, C. Ingre, K. Boylan, N. Graff-Radford, D. Dickson , D. Clay-Falcone, L. Elman, L. McCluskey, R. Greene, R.G. Kalb, V.M.Y. Lee, J.Q. Trojanowski, A.C. Ludolph, W. Robberecht, P.M. Andersen, G.A. Nicholson , I.P. Blair , O.D. King , N.M. Bonini, V. Van Deerlin, R. Rademakers , Z. Mourelatos, A.D. Gitler, A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci USA, 2011. 108 (52) 20881-20890. *These authors contributed equally. (Feature Article; Featured on the Cover) pdf 40. Gitler A.D., Another reason to exercise. Science, 2011. 334(6056):606-607. pdf 39. Liu-Yesucevitz
L., G. Bassell, A.D. Gitler, A.
Hart, E. Klann, J. Richter, S. Warren, B. Wolozin, Local RNA Translation at the Synapses and in Disease. J Neurosci, 2011. 31(45):16086-16093. pdf 38. Gitler, A.D.# and J. Shorter#, RNA-binding proteins with prion-like domains in ALS and FTLD-U. Prion, 2011. 5(3):179-187. #Co-corresponding authors. (Featured on the cover) pdf 37. Fleming, M. and A.D. Gitler, High-throughput yeast plasmid overexpression screen. J Vis Exp, 2011. 53. doi:
10.3791/2836. link to video 36. Bonini, N.M.#, A.D. Gitler#, Model organisms reveal insight into human neurodegenerative disease: Ataxin-2 intermediate length polyglutamine expansions are a risk factor for ALS. J Mol Neurosci, June 2011. #Co-corresponding authors. pdf 35. Sun, Z.*, Z. Diaz*, X. Fang, M.P. Hart, M. Armakola, A. Chesi, J. Shorter#, A.D. Gitler#, Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. PLoS Biol, 2011. 9(4): e1000614. *These authors contributed equally, #Co-corresponding authors. pdf
34. Yu, Z., Y. Zhu, A.S. Chen-Plotkin, D. Clay-Falcone , L. McCluskey, L. Elman, R.G. Kalb, J.Q. Trojanowski, V. M.-Y. Lee , V.M. Van Deerlin, A.D. Gitler#, N.M. Bonini#, PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. PLoS One, 2011. 6(3): e17951. #Co-corresponding authors. pdf 33. Konopka C.A., M.N. Locke, P.S. Gallagher, N. Pham, M.P. Hart, C.J. Walker, A.D. Gitler, R.G. Gardner. A yeast model for polyalanine-expansion aggregation and toxicity. Mol Biol Cell, 2011. 22(12):1971-1984. 32. Lee, T., Y.R. Li, A. Chesi, M.P. Hart, D. Ramos, N. Jethava, D. Hosangadi, J. Epstein, B. Hodges, N.M. Bonini#, A.D. Gitler#, Evaluating trinucleotide repeat expansions in ALS. Neurology, 200. 76(24):2062-2065. #Co-corresponding authors. pdf 31. Lee, T.*, Y.R. Li*, C. Ingre, M. Weber, T. Grehl, O. Gredal, M. de Carvalho, T. Meyer, O. Tysnes, G. Auburger, S. Gispert, N.M. Bonini, P.M. Andersen, A.D. Gitler, Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients. Hum Mol Genet, 2011. 20(9):1697-1700. *These authors contributed equally. (Featured on the cover) pdf 30. Armakola, M.*, M.P. Hart*, A.D. Gitler, TDP-43 toxicity in yeast. Methods, 2011. 53(3): 238-245. * These authors contributed equally pdf 2010 29. Elden*, A.C., H.J. Kim*, M.P. Hart*, A.S. Chen-Plotkin*, B.S. Johnson, X. Fang, M. Armakola, F. Geser, R. Greene, M. Lu, A. Padmanabhan, D. Clay, L. McCluskey, L. Elman, D. Juhr, P.J. Gruber, U. Rüb, G. Auburger, J.Q. Trojanowski, V. M.-Y. Lee, V.M. Van Deerlin, N.M. Bonini#, A.D. Gitler#, Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature, 2010. 466(7310):1069-1075. * These authors contributed equally, #Co-corresponding authors pdf 28. Xiong, Y., C.E. Coombes, A. Kilaru, A.D. Gitler, W.J. Bowers, V.L. Dawson, T.M. Dawson, D.J. Moore, GTPase Activity Plays a Key Role in the Pathobiology of LRRK2. PLoS Genet, 2010. 6(4): p. e1000902. pdf 27. Cushman*, M., B.S. Johnson*, O.D. King, A.D. Gitler#, J. Shorter#, Prion-like disorders: blurring the divide between transmissibility and infectivity. J Cell Sci, 2010. 123(8):1191-1201. * These authors contributed equally, #Co-corresponding authors pdf 2009 26. Johnson, B.S., D. Snead, J.J. Lee, J.M. McCaffery, J. Shorter#, A.D. Gitler#, TDP-43 is intrinsically aggregation-prone and ALS-linked mutations accelerate aggregation and increase toxicity. J Biol Chem, 2009. 284(30): p. 20329-20339. #Co-corresponding authors pdf 25. Gitler, A.D., Disease models and mechanisms in the classroom. Dis Model Mech, 2009. 2(3-4):103-106. (Featured in a Podcast) pdf 24. Yeger-Lotem E., L. Riva, L.J. Su, A.D. Gitler, A.G. Cashikar, O.D. King, P.K. Auluck, M.L. Geddie, J.S. Valastyan, D.R. Karger, S. Lindquist, E. Fraenkel, Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet, 2009 41(3):316-323. pdf 23. Gitler A.D.*, A. Chesi*, M.L. Geddie*, K.E. Strathearn, S. Hamamichi, K.J. Hill, K.A. Caldwell, G.A. Caldwell, A.A. Cooper, J.C-R. Rochet, S. Lindquist, α−Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet, 2009 41(3):308-315. * These authors contributed equally pdf 22. Rappley, I., A.D. Gitler, P.E. Selvy, M.J. Lavoie, B.D. Levy, H.A. Brown, S. Lindquist, D.J. Selkoe, Evidence that alpha-Synuclein Does Not Inhibit Phospholipase D. Biochemistry, 2009 48(5):1077-1083. pdf 21. Sun, Z. and A.D. Gitler, Discovery and characterization of three novel synuclein genes in zebrafish. Dev Dyn, 2008 237(9):2490-2495. (Featured on the cover) pdf 20. Johnson B.S., J.M. McCaffery, S. Lindquist, A.D. Gitler, A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci USA, 2008, 17:6439-44. pdf 19. Gitler, A.D.*, Bevis, B.J.*, J. Shorter, K. Strathearn, S. Hamamichi, J. Su, K.A. Caldwell, G.A. Caldwell, J.C. Rochet, J.M. McCaffery, C. Barlowe, S. Lindquist, The Parkinson’s disease protein α−synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci USA, 2008, 1:145-50. * These authors contributed equally pdf 18. Gitler, A.D., Beer and bread to brains and beyond: Can yeast cells teach us about neurodegenerative disease? NeuroSignals, 2008, 16:52–62. (Featured on the cover) pdf 2007 17. Alberti, S.*, A.D. Gitler*, S. Lindquist, A suite of yeast Gateway vectors for high-throughput genetic analysis. Yeast, 2007, 24(10):913-9. * These authors contributed equally pdf 16. Gitler, A.D.* and J. Shorter*, Prime Time for α−Synuclein. J. Neuroscience, 2007, 27:2433-2434. * Co-corresponding authors pdf 2006 15. Wu J, M. O'Donnell, A.D. Gitler, P.S. Klein, Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development, 2006, 133(18):3651-60. pdf 14. Cooper, A.A.*, A.D. Gitler*, A. Cashikar, C. Haynes, K. Hill, B. Bhullar, K. Liu, K. Xu, K.E. Strathearn, F. Liu, S. Cao, K.A. Caldwell, G.A. Caldwell, G. Marsischky, J. LaBaer, R.D. Kolodner, J.C. Rochet, N.M. Bonini, and S. Lindquist, α−Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science, 2006. 313:324-328. * These authors contributed equally pdf 2005 13. Engleka, K.A., A.D. Gitler, M. Zhang, D.D. Zhou, F.A. High, and J.A. Epstein, Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Dev Biol, 2005. 280(2): p. 396-406. pdf 2004 12. Torres-Vazquez, J.*, A.D. Gitler*, S.D. Fraser*, J.D. Berk, N.P. Van, M.C. Fishman, S. Childs, J.A. Epstein, and B.M. Weinstein, Semaphorin-plexin signaling guides patterning of the developing vasculature. Dev Cell, 2004. 7(1): p. 117-23. * These authors contributed equally pdf 11. Gitler, A.D., M.M. Lu, and J.A. Epstein, PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell, 2004. 7(1): p. 107-16. pdf 10. Gitler, A.D.*#, Y. Kong*#, J.K. Choi, Y. Zhu, W.S. Pear, and J.A. Epstein, Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatr Res, 2004. 55(4): p. 581-4. * These authors contributed equally, #These authors are married (Featured on the cover) pdf 9. Gitler, A.D. and J.A. Epstein, Regulating heart development: the role of Nf1. Cell Cycle, 2003. 2(2): p. 96-8. (Featured on the cover) pdf 8. Gitler, A.D., M.M. Lu, Y.Q. Jiang, J.A. Epstein, and P.J. Gruber, Molecular markers of cardiac endocardial cushion development. Dev Dyn, 2003. 228(4): p. 643-50. pdf 7. Gitler, A.D.*, Y. Zhu*, F.A. Ismat, M.M. Lu, Y. Yamauchi, L.F. Parada, and J.A. Epstein, Nf1 has an essential role in endothelial cells. Nat Genet, 2003. 33(1): p. 75-9. * These authors contributed equally pdf 6. Kochilas, L.K., V. Potluri, A. Gitler, K. Balasubramanian, and A.J. Chin, Cloning and characterization of zebrafish tbx1. Gene Expr Patterns, 2003. 3(5): p. 645-51. pdf 5. Kook, H., J.J. Lepore, A.D. Gitler, M.M. Lu, W. Wing-Man Yung, J. Mackay, R. Zhou, V. Ferrari, P. Gruber, and J.A. Epstein, Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest, 2003. 112(6): p. 863-71. pdf 4. Gitler, A.D., C.B. Brown, L. Kochilas, J. Li, and J.A. Epstein, Neural crest migration and mouse models of congenital heart disease. Cold Spring Harb Symp Quant Biol, 2002. 67: p. 57-62. pdf 3. Chen, F., H. Kook, R. Milewski, A.D. Gitler, M.M. Lu, J. Li, R. Nazarian, R. Schnepp, K. Jen, C. Biben, G. Runke, J.P. Mackay, J. Novotny, R.J. Schwartz, R.P. Harvey, M.C. Mullins, and J.A. Epstein, Hop is an unusual homeobox gene that modulates cardiac development. Cell, 2002. 110(6): p. 713-23. pdf 2. Lu, M.M., F. Chen, A. Gitler, J. Li, F. Jin, X.K. Ma, and J.A. Epstein, Cloning and expression analysis of murine lupin, a member of a novel gene family that is conserved through evolution and associated with Lupus inclusions. Dev Genes Evol, 2000. 210(10): p. 512-7. pdf 1. Gunatilaka, A.A., V.J. Paul, P.U. Park, M.P. Puglisi, A.D. Gitler, D.S. Eggleston, R.C. Haltiwanger, and D.G. Kingston, Apakaochtodenes A and B: two tetrahalogenated monoterpenes from the red marine alga Portieria hornemannii. J Nat Prod, 1999. 62(10): p. 1376-8. pdf |