Description Ovaries are small almond shaped female reproductive organs. Females have two ovaries which are located deep in the pelvis, one on each side of the uterus. Ovaries make female hormones and they store egg cells, which are released once a month during ovulation.
This picture shows where in the body the ovaries are. [1] Though there are many different types of ovarian cancer, I will only talk about the most common type, epithelial ovarian cancer. This type of cancer is responsible for nearly 9 out of 10 cases. When someone says that they have ovarian cancer, they are usually referring to this type. Epithelial ovarian cancer cells have certain features when seen under a microscope which allow doctors to classify them. Epithelial tumors start from the epithelial cells which are outside the ovaries and spread from there. Epithelial tumors are graded on a scale from one to three based on how healthy the cell looks compared to non-cancerous cells. With a grade of one, the tumor looks less cancerous; grade three looks more cancerous, and grade two is in between. Usually, when a cell gets a higher grade, the chances the person will live is lower. [1]
Ovarian cancer starts when epithelial cell begin to grow out of control. Normal cells divide and die in a very controlled way, but cancer cells do not. They continue to grow out of control and crowd out normal cells. Sometimes cancer cells break away from a tumor and spread to other parts of the body through the lymph system. The new places where they settle form tumors. This is called metastasis and cancer that has spread in this way is called metastatic cancer. [2]
The best predictor of a woman getting ovarina cancer is if a family member got breast or ovarian cancer at a relatively young age (before 50 years old). Another risk factor if if a woman has never had children, never breastfed. [6] Other believe that older women are more likely to get ovarian cancer because they've had more exposure to environmental factors such as: the body's hormones, asbestos exposure, or smoking. Though any female can developed ovarian cancer, over half the women are over 60 years old. [3] There are about 30,000 new cases of ovarian cancer each year, and 15,000 deaths. The risk of developing ovarian cancer for women born in the United States is almost 2%. A 5-year survival rate is the percentage of surveyed people, who after five years without ovarian cancer symptoms, have survived. The overall 5-year ovarian cancer survival rate from 1996-2002 was 44.7%. For that same time frame, the survival rate for white women was 44.2 percent and the survival rate for black women was 39.5 percent. [4] What is Cancer? [1]
This is an image of a cancerous ovary. [2]
This is a person undergoing chemotherapy, one of the treatments for ovarian cancer (more information about treatments is below). The physical effects chemotherepy has on the human body are: hair loss, hand and foot rashes and mouth sores. [3]
This is an image of a radiation therapy patient with the sun burn effect. This means the skin is red, itchy and sore requiring cream. For ovarian cancer the sunburn effect will be in the abdominal area where the treatment is focused. [4]
Treatment
The three main treatments for ovarian cancer are: surgery, radiation therapy and chemotherapy.
Surgery The type of surgery recommended for ovarian cancer depends on how far the cancer has spread, the general health of the patient, and whether or not the patient still has hope to have children. The two main goals for surgery are: staging the cancer and removing as much of the tumor as possible. When staging the cancer, doctors different types of tissue to see how far from the ovary the cancer has spread. Staging is important because at different stages of ovarian cancers it is treated differently. Staging must be done right or the doctor may not give the right treatment. During staging the uterus, both ovaries, and both fallopian tubes are removed. The omentum is also removed. The omentum is a fatty layer of tissue that covers the stomach. Ovarian cancer sometimes spreads to this tissue. Some lymph nodes in the pelvis and abdomen are taken out to see if they contain cancer. Any fluid in the abdominal area will also be removed. The other goal of surgery is to debulk or remove as much of the tumor as possible. The goal of this surgery is to have no tumors larger than 1 cm left behind. A successful debulking surgery means the patient has a better outlook than those left with larger tumors after surgery. Most women will stay in the hospital for 3 to 7 days after the operation and can resume their usual activities within 4 to 6 weeks.
This image shows the procedures done in a staging surgery for ovarian cancer. [12]
Chemotherapy Chemotherapy (often called "chemo") refers to killing cancer cells using drugs. When drugs aren taken as pills, they spread throughout the body and are helpful when cancer has spread beyond the ovaries. When the drugs are injected directly into the abdomen, they go right to the cancer cells. This limits the amount reaching the rest of the body and therefore reduces side effects. Chemo is usually given in cycles of treatment followed by a rest period. Chemo drugs kill cancer cells, but they also damage normal cells, causing side effects.
Some side effects are:
What is Chemotherapy? [2]
Radiation therapy
Radiation therapy is when high energy x-rays are used to kill or shrink cancer cells. The radiation may come from radioactive materials placed directly into or near the tumor or from outside the body. Radiation treatment may cause side effects. These side effects include:
§ tiredness § nausea § diarrhea
The skin might look red and sunburned. It might also be itchy and dry. The skin returns to normal within 6 to 12 months. [5] This is an image demonstrating how radiation therapy works. [6]
Because early stage ovarian cancer has few symptoms, most women discover the cancers later on when they have spread beyond the ovaries. As a result, most of the treatments are not very effective unless the cancer is caught early. The survival rate for ovarian cancer is only 50% overall.
This table shows the percentage of cases that are discovered in each stage and the survival rate for each. [13]
Research
Research for a new and more effective cure is being done because chemothereapy and radiation therapy kill not only cancerous cell, but healthy ones as well. They are trying to make a "smart" treatment that would only kill cancerous cells. Molecularly targeted treatments take advantage of how the cancer process can be set in motion by genetic mutations. When one step is shutt off, the whole process is shut down. Many are designed to target proteins from when the gene was mutated. [7]
This is a scientest named Anthony Martinez who is working on a molecularly targeted treatment which unlike origianal chemotherapy drugs is molecularly targeted to create fewer side effects. [7]
Another promising topic being researched is Monoclonal antibodies. Antibodies protect our bodies against any threats. Monoclonal antibodies are engineered to attach to cancer cells. Research is being done to not only make them destroy cancer cells but to also deliver anticancer drugs, radioactive substances, and other toxins directly to them. When the antibodies attach to the cancer cells they can give poisons only and directly to the tumor. [7]
Yet another research topic is T- cell therapy. Scientists take CD4+ T cells from the patient and enlarge and clone them. T- cells are killer cells that fight off foreign intruders so they kill the cancer cells. A man with advanced melanoma cancer had his tumor disappear two months after T-cell infusion. [10,11]
Antibody Immune Response [3]
Current Events
One of the promising new breakthroughs is a vaccine that can cure cancer even in its later stages. Ovarian cancer is called the silent killer because there are few symptoms until later stages, so it is significantly important that the vaccine can treat cancer in all stages. Each tumor is different, so this vaccine is made specifically for each patient by taking tissue from the tumor to create the vaccine. The vaccine is put into the abdominal cavity combined with chemotherapy. This treatment is low toxicity and works with the patient's immune system. [8]
This is the picture of the vaccine for Ovarian Cacer explained above. [8] Breakthrough Vaccine [4]
Another discovery helping cure cancer patients is the delivery of chemotherapy directly into the abdominal cavity through a catheter. This makes it possible to give a higher dosage without killing as many normal cells so more cancer cells are harmed. There aren't side effects such as abdominal discomfort and infections from the catheter. Doctor Zanotti says "doctors are working to improve catheters and improve the delivery."[9]
This is an image of the chemotherapy drugs going into the abdomine. [5]
The Callaway Golf Foundation and the Entertainment Industry Foundation partnered up to inform people and raise money for finding a cure for ovarian cancer. They are discovering breakthrough treatments that can greatly improve the outcome for cancer patients. This is a periodical article about this:
The lead cause of cancer of the female reproductive system, Ovarian cancer, is proven to be genetic. In this article you will learn about how scientists will try to pinpoint families with a cancerous lineage and check all members to try to catch cancer at an earlier stage.
Genetics It is thought that if one relative had either ovarian or another type of cancer, like breast cancer, the woman has a higher chance of getting ovarian cancer. Five to ten percent of individuals who have developed ovarian cancer have a strong cancer history.
Another way of genetically getting ovarian cancer is through genetic alteration. In 1994, an ovarian cancer susceptibility gene called BRCA1 located at 17q21 and in 1995 BRCA2 located at 13q12 were identified and discovered. Women with this alternation are more likely to get ovarian cancer. A woman with BRCA1 and BRCA2 alternations has a 50% chance of passing it to her children. In this case it is a germline mutation. [3,6]
This is a punnett square showing the chances of the offspring of these parents getting ovarian cancer. Genetic Mutation [5]
A Day in a Life
My day-to-day routine is very similar to before I got Ovarian Cancer, fortunately at an early stage. I get up, get ready, eat breakfast, go to work, come home, eat dinner, go to bed, and sometime during the day, go to radiation therapy. It’s just as simple as it used to be except I am occasionally in pain and have to spend about half an hour in radiation therapy every day. I'm one of the lucky people because I don't get any of the occasional tiredness, nausea and diarrhea I've heard radiation therapy can cause.
Though my schedule and routines are the same as for a healthy person, my view on life is not. I am thankful for every day I live because I know that they may be few since my chances of surviving are is only 50%. I'm stressed because I want to live but my body just wont cooperate; it's not fighting the cancer fast enough.
This is what today’s schedule looks like. You might want to compare it to your own. I bet you won’t find much of a difference if you’re a working adult.
This shows the different things a person with ovarian can do. [10]
A Day at Radiation Therapy [6]
Vocabulary
Ovaries- a reproductive organ in women and female animals in which eggs are produced. Epithelial cells- cells that cover the ovary. Most ovarian cancers start in this covering. Epithelial tumors- tumors that start from the cells that cover the outer surface of the ovaries. Most ovarian tumors are epithelial cell tumors. Metastasis- the transfer of disease or malignant cells from one part of the body to another through the blood, lymph, or membranes, or the resulting condition, as in tuberculosis or cancerous tumors. Omentum- a layer of fatty tissue that covers the stomach. Debulk- to remove all or most of the substance of a tumor. Germline mutation- a mutation present in the reproductive cells, and thus is transmissible to offspring. BRCA1- a human gene that belongs to a class of genes known as tumor suppressors. BRCA2- a human gene that is involved in the repair of chromosomal damage.
This is a picture of a dictionary. [11] Bibliography
"Breakthrough Vaccine to Treat Chemo-Resistant Ovarian Cancer." Bio-Medicine. March 9, 2007. Bio-Medicine. 5 Jan 2009 <http://www.bio-medicine.org/biology-news/Breakthrough-vaccine-to-treat-chemo-resistant-ovarian-cancer-5051-1/.>
"Can Ovarian Cancer Be Prevented?" Cancer Reference Information . 02/06/2008. American Cancer Society. 10 Dec 2008 <http://www.cancer.org/docroot/CRI/content/CRI_2_2_2x_Can_Ovarian_Cancer_Be_Prevented.asp?sitearea=>.
Conner, Kristine, and Lauren Langford. Ovarian cancer- Your Guide to Taking Control. 1st. Sebastopol, CA: O'Reilly & Associates, Inc, 2003.
"Frequently asked questions- Ovarian Cancer." Womenshealth.gov. December 5, 2008. Office on Women's Health. 04 December 2009. <http://www.4woman.gov/faq/ovarian-cancer.cfm.>
Gale, Thomson. "Ovarian Cancer."The Gale Encyclopedia of Genetic Disorders. 2nd. 2005.
"How Is Ovarian Cancer Found?" Cancer Reference Information. 02/06/2008. American Cancer Society. 12 Dec 2008 <http://www.cancer.org/docroot/CRI/content/CRI_2_2_3X_How_is_ovarian_cancer_found_33.asp?rnav=cri>.
"How Many Women Get Ovarian Cancer?" Cancer Reference Information. 02/06/2008. American Cancer Society. 08 Dec 2009 <http://www.cancer.org/docroot/CRI/content/CRI_2_2_1X_How_many_women_get_ovarian_cancer_33.asp?sitearea>. "Incidence and Prevalence ." oncologychannel. 15 Aug 1999. Healthcommunities.com. 23 Jan 2009 <http://www.oncologychannel.com/ovariancancer/index.shtml>.
National Cancer Institute, "Ovarian Cancer Symptoms and Treatments." Heart Spring. National Cancer Institute. 08 Dec 2008. <http://heartspring.net/ovarian_cancer_symptoms.html>.
"Ovarian Cancer Breakthrough." Eyewitness news. 2008. Eyewitness news. 9 Jan 2009 <http://www.wchstv.com/newsroom/healthyforlife/2493.shtml#transcript>.
"Ovarian Cancer- Definition/Description/Cause & Symptoms." All About Ovarian Cancer. 02 December 2008. 06 Dec 2008. <http://myovary.wordpress.com/02/12/2008/ovarian-cancer-definitiondescriptioncause-symptoms/>.
"Ovarian Cancer." Centers for Disease Control and Prevention. June 23, 2008. Department of Health and Human Services. 2 Jan 2009. <http://www.cdc.gov/cancer/ovarian/.>
"Ovarian Cancer." U.S. National Institutes of Health. National Cancer Institute. 06 Dec 2008 <http://www.cancer.gov/cancertopics/types/ovarian>.
"Ovarian Cancer." UCSF Medical Care. June 20, 2007. UCSF. 3 Jan 2009 <http://www.ucsfhealth.org/adult/medical_services/cancer/pelvic/conditions/ovarian/signs.html?gclid=CPLN_M70n5cCFSAUagodJ380ow.>
Schoenstadt, Arthur . "Ovarian Cancer Survival Rate." MedTV. October 01, 2006. MedTV. 7 Jan 2009 <http://ovarian-cancer.emedtv.com/ovarian-cancer/ovarian-cancer-survival-rate.html.>
Sutton, Amy L. Cancer Sourcebook for women. 3rd. Detroit, MI: Omnigraphics, Inc, 2006.
"What's New in Ovarian Cancer Research and Treatment?" Cancer Reference Information. 02/06/2008. American Cancer Society. 15 Dec 2008 <http://www.cancer.org/docroot/CRI/content/CRI_2_2_7x_Whats_New_in_Ovarian_Cancer_Research_and_Treatment.asp?sitearea=.> "What Causes Ovarian Cancer?" Cancer Reference Information . 02/06/2008. American Cancer Society. 04 Dec 2008 <http://www.cancer.org/docroot/CRI/content/CRI_2_2_2X_What_causes_ovarian_cancer_33.asp?sitearea=>.
"What Is Ovarian Cancer?" Cancer Reference Information . 02/06/2008. American Cancer Society. 07 Dec 2009 <http://www.cancer.org/docroot/CRI/content/CRI_2_2_1X_What_is_ovarian_cancer_33.asp?rnav=cri.>
References 3. Gale, Thomson. "Ovarian Cancer."The Gale Encyclopedia of Genetic Disorders. 2nd. 2005. 4. Schoenstadt, Arthur . "Ovarian Cancer Survival Rate." MedTV. October 01, 2006. MedTV. 7 Jan 2009 <http://ovarian-cancer.emedtv.com/ovarian-cancer/ovarian-cancer-survival-rate.html.> 6. Sutton, Amy L. Ovarian Cancer Sourcebook for Women. 3rd. Detroit, MI: Omnigraphics, Inc, 2006. 7. Conner, Kristine, and Lauren Langford. Ovarian cancer- Your Guide to Taking Control. 1st. Sebastopol, CA: O'Reilly & Associates, Inc, 2003. 8. "Breakthroughz vaccine to treat chemo-resistant ovarian cancer." Bio-Medicine. March 9, 2007. Bio-Medicine. 5 Jan 2009 <http://www.bio-medicine.org/biology-news/Breakthrough-vaccine-to-treat-chemo-resistant-ovarian-cancer-5051-1/.> 9. "Ovarian Cancer Breakthrough." Eyewitness news. 2008. Eyewitness news. 9 Jan 2009 <http://www.wchstv.com/newsroom/healthyforlife/2493.shtml#transcript>.
10. "Case Report of Advanced Melanoma Disappearing After T Cell Therapy." Medscape Medical News. June 20, 2008. Medscape Today. 22 Jan 2009 <http://www.medscape.com/viewarticle/576378>.
11. "Adoptive Immunotherapy for the Prevention of Recurrence." Pacific Ovarian Cancer Research Consortium. POCRC. 22 Jan 2009 <http://www.pocrc.org/researchers/projects/immunotherapy-project.html>.
Picture Credits
1. "What Is Ovarian Cancer?" Cancer Reference Information . 02/06/2008. American Cancer Society. 07 Dec 2009 <http://www.cancer.org/docroot/CRI/content/CRI_2_2_1X_What_is_ovarian_cancer_33.asp?rnav=cri.> 2. “Ovarian cancer." AARP.org. 6/10/2008. Ovarian cancer. 1 Jan 2009 <http://assets.aarp.org/external_sites/adam/html/2/8655.html>. 3. "Desperate Housewives' Lynette battles against cancer." thisislondon.co.uk. 01/10/07. Showbiz News. 2 Jan 2009 <http://www.thisislondon.co.uk/showbiz/article-23414494-details/Desperate+Housewives'+Lynette+battles+against+cancer/article.do>. 4. "What to Expect." Queensland Health. 10 January 2008. Queensland Government. 7 Dec 2008 <http://www.health.qld.gov.au/pahospital/radonc/whattoexpect.asp>. 5. "Chemotherapy into your abdomen." What. 25 March 2008. Cancer Research UK. 16 Jan 2009 <http://www.cancerhelp.org.uk/help/default.asp?page=5450>. 6. "Radiation therapy ." Medical Encyclopedia. 9/30/2008. Medline Plus. 10 Jan 2009 <http://www.nlm.nih.gov/medlineplus/ency/imagepages/9805.htm>. 7. "Cautious optimism." Synthesis. Spring/Summer 2006. UC Davis Cancer Center. 11 Jan 2009 <http://www.ucdmc.ucdavis.edu/Synthesis/issues/spring_summer_06/features/in_translation.html>. 8. "Survey Unveils HPV Vaccine Confusion." TopNews.in. 09/05/2007. TopNews.in. 13 Jan 2009 <http://www.topnews.in/survey-unveils-hpv-vaccine-confusion-21340>. 9. "Genetics of Hereditary Breast & Ovarian Cancer." DNA Direct . DNA Direct . 18 Jan 2009 <http://www.dnadirect.com/web/article/testing-for-genetic-disorders/breast-and-ovarian-cancer-risk/20/genetics>. 10. "Welcome to the Work Life Program." Human Resources Department. Jun 30, 2008. UCSB. 18 Jan 2009 <http://hr.ucsb.edu/worklife/>. 11. "Clip Art Graphic of a Book Cartoon Character With Welcoming Open Arms." Image Envision. Image Envision. 15 Jan 2009 <http://www.imageenvision.com/stock_clipart/details/0025-0802-2010-0504/book_cartoon_character_with_welcoming_open_arms>. 12. "Diagnosis." Cancerfacts.com. 10/21/2008. 23 Jan 2009 <http://www.cancerfacts.com/GeneralContent/Ovarian/Gen_Diagnosis.asp?CB=9>. 13. "About Ovarian Cancer." NOCC. NOCC. 23 Jan 2009 <http://images.google.com/imgres?imgurl=http://www.dfwovarian.org/images/Slide30.jpg&imgrefurl=http://www.dfwovarian.org/gillette.html&usg=6pvqgOdPoke_fehZSTpC3U3VMsA=&h=744&w=1352&sz=124&hl=en&start=5&tbnid=_KKnfNwzOeO_DM:&tbnh=83&tbnw=150&prev=/images%3Fq%3DSurvival%2Brate%2Bof%2Bovarian%2Bcancer%26gbv%3D2%26hl%3Den>. Video Credits
Picasa Slideshow
I made this slideshow but on my mom's picasa account by accident and didn't have time to retype all the captions.
Bonus
Across
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he keep working
whos is this
hey
i like it so far
keep working
!!!!!!!!!!!!!!!!!!!!!!!!!
GREAT START!
This is Good!
This is Maya
Thanks for the comments!
This is a great start. I want to encourage you to put things even more in your own words. I appreciate how well you have cited different sources.
wow lots of sources do you have any tips for mine i think that in some parts it sounds just a tad stiff
WOW this is really really REALLY good caan u give me some tips to please?!?!?!!?1
Awesome job maya!
your bibliography is perfect
good job but the picture that has the citation 10 the description should be can do instead of still do, if you want cause the other way is a little choppy. other wise its amazing
I love all ur pictures.
Very impressive! You obviously put a HUGE amount of effort into this. A+