Genetic Disorders: 7th Grade

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Amyotrophic Lateral Sclerosis - Kyra

 Kyra's page.
Hello, and welcome to the Amyotrophic Lateral Scelrosis(it's so hard to pronounce!), or Lou Gehrigs disease(that's better) info page. Nevermind, I'll just call it ALS. Well anyways, ALS is a disease that affects your nerve cells in the brain and the spinal chord. As a result of that, it causes muscle weakness and atrophy.
 
 What is ALS?
Overview
ALS is a genetic disorder that, like I said before, causes weakness and cramping in the muscles
  • would have twitching mostly in the hands and feet 
  • shortness of breath
  • and a hard time swallowing
There are no environmental factors contributing to ALS, so it is completely genetic.
(1)
Unfortunately, there is no cure for ALS, but some scientists believe that stem cells can help grow back the damaged muscle tissue.

Treatment
Like I said before, there is no cure for ALS, but some scientists belive that stem cell therapy can reduce symptoms. Also, for the first time, the FDA(federal drug administration), has approved a drug for the disease called RILUZOLE. RILUZOLE is proven to reduce the damage of motor nueron and prolong survival for several months, and it especially helps patients that have a hard time breathing and swallowing.
After some of the treatments, the results were, (out of 53 people)(2)
(3)

Some symptoms of riluzole are:
  • nausea
  • vomiting
  • dizzinis
  • drowsiness
  • weakness
Some symptoms of Stem Cell treatment are like chemotherapy symptoms:
  • anemia
  • hairloss
  • neutropinia, a condition that causes a person to have an unsually low number of a type of white blood cell called, neutrophil.




Research
Scientist's are trying to find a cure by a treatment. The biggest research being done is with the National Institute of Neurological Disorders and Stroke. They are are trying to find the causes, or cause, of the disease, and are trying to understand the diseases mechanisms, and why it attacks.



 

Current Events
There have been many stories on ALS, and one of them says that in Kansas City, 2,000 people showed up for the Walk to d'feet ALS. The walk raised about $250,000 for ALS research.
Another story is about a Pheonix leiutenant officer who traveled to Isreal to get ALS treatment when he was so far through ALS that he couldn't speak, and so far that the disease was about to take his life.null

It is hard to have ALS because after you are diagnosed with ALS,  you have about three years to live. The disease starts attacking your muscle nerves, until you have to use a breathing device.
Picture from: philloseth.ca

A  Day in The Life

A typical day ALS is hard because you get weaker and weaker every day. One woman with ALS has to have people help her get in the shower and do every day to day things like going to the bathroom. She must take Rilutek, 4 Vitamin C's  and 6 Vitamin E's. She has a physical therapist come every week to help her with her twitching.  It is frustrating for her, and everyone, because you need someone to help you do daily activities.4)

Picture from:
www.prweb.com/.../prweb513940.htm



Genetics

ALS is a mutation. Some scientists believe that the mutation impairs enzymes. The mutation doesn’t occur in family ALS often, but if a parent does have ALS, then the child has a 50% chance of inheriting it from the mother or the father. 
 
Picture from: www.dsf.health.state.pa.us/.../genetics.jpg
 

Picasa Slideshow
Go to:
 
 
 
 
Bonus

1
2   3         4
5      
  6                  
     
    7              
8              
     
  9              
 
10
 
 
 
 
 
 
Across
2. A result of a medication.
6. A type of treatment for ALS.
7. Lack of strength.
8. Passed through genes.
9. disruption
Down
1. A famous baseball player with ALS.
3. A diruption in chromosomes.
4. A disease that attacks your motor neurons.
5. A tendon affected by s
10. Tired or effected from lack of use.

Vocabulary
  • Riluzole
  • Amyotropihc Lateral Sclerosis
  • Neutropinia


 
Bibliography
1) Ben-Joseph, Elena Pearl. "Lou Gehrig's disease(ALS)." Kids Health For Kids. September 2006. 16 Jan 2009 <http://kidshealth.org/kid/grownup/conditions/als.html>.
2)"What is ALS." ALS Association. 10/2008. 16 Jan 2009 <http://www.alsa.org/als/what.cfm?CFID=2508664&CFTOKEN=1b22cb868a75b316-E19B0C9A-188B-2E62-802C2F16C1CF547E>.
3)"PR Web." 22 Jan 2009 < www.prweb.com/.../prweb513940.htm>.
4)<http://philloseth.ca/>.
5)"Walk To d'feet ALS." 22 Jan 2009 <http://www.kctv5.com/calendar/13832503/detail.html>.
6)"Research Overview." Research at BTI. 22 Jan 2009 <bti.cornell.edu/researchOverview.php>.
7)"Amyotrophic Lateral Sclerosis (ALS)- Top Overview." Yahoo Health. 22 Jan 2009 <http://health.yahoo.com/nervous-overview/amyotrophic-lateral-sclerosis-als-topic-overview/healthwise--hw179632.html>.
8)http://dictionary.reference.com/browse/riluzole
9)"Very Important Books & Resources for ALS." Even Better Now. 22 Jan 2009 <http://www.evenbetternow.com/als.asp?s=yahoo2&OVRAW=ALS%20research&OVKEY=als%20research&OVMTC=standard&OVADID=4441503512&OVKWID=76839295012>.
10)"ALS Symptoms." EMed TV. 22 Jan 2009 <http://als.emedtv.com/als/als-symptoms.html>.




Resources
1) <http://www.alsa.org/als/what.cfm?CFID=2540404&CFTOKEN=540da29e531f2e1a-01867AF8-188B-2E62-808BEDE888C0D265>
2) and 3) http://www.xcell-center.com/treatments/diseases-treated/als.aspx
4) http://www.alstalk.org/archives/Messages/ATypicalDayforsomeonewith.html
 

Comments (15)

Annette Dolby - Dec 10, 2008 8:26 PM

whos doing this deises
oh and good

Maya L.I. - Dec 12, 2008 2:54 PM

I love how conversational your page is!!!!!!!
It has lots of character

Annette Dolby - Dec 13, 2008 10:56 AM

this is really goood
i like the diagrams

Carina Salaiz - Dec 17, 2008 4:30 PM

Keeda Heeda
YOUR PAGE IS AWESOME!!!!!!!!!!!!!!
you have so much information!

Tommy Bliss - Dec 28, 2008 6:54 PM

This is really good Kyra!

sarah Rubenstein - Jan 12, 2009 6:23 PM

Good work. I like the pictures and I can tell you wrote in your own words. Don't forget to cite where the pictures are from.

Sophie V - Jan 17, 2009 3:33 PM

it looks nice. good pictures.

Carinn C - Jan 20, 2009 5:18 PM

i like how u made the headings nice and visible, but don't forget to indent on your paragraphs. Other than that, i can TOTALLY tell it wasn't written when u were in kindergarden, teehe. keep up the great work kyra!

anastasia fry - Jan 20, 2009 6:13 PM

this is great kyra u nose horn!!!

Annette Dolby - Jan 21, 2009 10:39 AM

i like the colors and the pictures

Eliza B. - Jan 21, 2009 6:27 PM

i heart your page! good pictures, but i would cite a couple more sources

Annette Dolby - Jan 22, 2009 7:26 PM

good but do a different section for citations, but otherise good

Carinn C - Jan 22, 2009 7:38 PM

i really like how u put the pictures right under the caption, very clever

Lauren Clark - Jan 22, 2009 7:44 PM

The graph is excellent! Totally original.

Maya L.I. - Jan 23, 2009 10:12 PM

If you put a paragraph in a day in a life in the point of view of a person with ALS, you could show the persons feelings about having the disorder better. Besides that it is REALLY good! Nice work!