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This is a fun online demo showing how life could have arisen from non-living chemicals. The demo uses an imaginary chemistry with red, green and blue "molys" that can bond together and yellow "polys" that can form membranes. As generations pass, order arises from chaos and competition between bond combinations causes some molys to dominate. The demo includes a slide show with thought-provoking questions and references for further exploration. Be sure to scroll down to New Developments for new research in this area.
Contact CraigHyatt@live.com for more info.
MOLYPOLY LINKSClick here to open the demo in your browser (requires Adobe Flash).
Click here to download a stand-alone application (zipped) for Windows XP or Vista.
Click here to download the source code (zipped):
GENETIC ALGORITHMSRobby the RobotI read an excellent book by Melanie Mitchell, Complexity: A Guided Tour. I simply cannot recommend this book highly enough. Dr. Mitchell gathers in one place some of my favorite topics such as chaos, cellular automata, genetic algorithms, artificial intelligence (analogies), networks, and scalability. I like these topics because they live on the boundary between computer science and biology. What makes this book special is how clearly Dr. Mitchell explains things using fun and interesting examples. One that caught my eye her Robby the Robot demo, in which a robot evolves progressively better solutions to picking up cans in a 10x10 grid. I am still working on the software and will post updates as they come.
Robby starts with population of random genes with each gene containing a stragegy for picking up the cans. Robby is a pretty dumb robot: he can't see beyond the square he's sitting on, he can't count squares, he has no memory, and he doesn't even know there's a can in his square until he tries to pick it up. Robby gets 10 points for every can he picks up, but he loses points for crashing into a wall (-5) or trying to pick up a can when there isn't one (-1). Since there's a 50/50 random chance that a square has a can and there are 10x10=100 squares, then there should be about 50 cans to pick up. At 10 points apiece and with no penalty points, the best Robby can score is 500.
In one generation, Robby collects the cans and the simulator keeps track of his score (fitness) for each strategy (gene) in the population. When all of the genes have been scored, the collection of genes in the population becomes the basis for a new generation. Here's how they are combined: a pair of genes is randomly selected, but the chance of selection is better for genes with higher fitness scores. Each member of the pair of selected genes is split at some random location and rejoined, taking a piece from each parent gene to produce a new combined gene to be added to the next generation's population. Just to make things interesting, a random mutation is introduced at this time. Once a new generation is created, Robby picks up cans using the evolved strategy, scores each gene, and the whole process repeats. As each generation is built from the previous genetic population, genes with the best scores have the greatest chance of remaining in the gene pool. Robby starts with completely random genes initially, and he usually does so badly that he has a negative score! But as Robby's strategy evolves, his score gradually improves and approaches the theoretical best score of 500. Dr. Mitchell reports that her Robby got as high as 483 which is pretty close to optimal... so far, I'm only getting 300, but I probably still have bugs in my code. :)
ORIGIN OF LIFE PRESENTATIONNEW DEVELOPMENTSScientific American Article
Self-ReplicationPerhaps it's a case of life imitating art, but Gerald Joyce and Tracey Lincoln have made a completely artificial molecule that self-replicates and evolves. In this case the "secret sauce" for the evolving forms isn't bond longevity as in my model, but replication speed.
Alternative Life FormsI just discovered the book Life As We Do Not Know It by Peter Ward. This book gives more detail about some of the things I was wondering about when I wrote MolyPoly. What I tried to do in MolyPoly was come up with some--any--kind of rational story that might explain how life arose from non-living matter. It didn't have to make sense chemically (other than bonds forming and breaking), but I wanted to convince myself that there was a plausible way that organic molecules formed themselves into replicating units that eventually took up residence inside a membrane. I asked myself things like: Why is a membrane important? If it weren't an important part of the story, then modern cells would not have cell walls. Another one: What's the absolute simplest way molecules could replicate? What factors could cause them to compete and evolve?
One little tidbit I got from Ward's book was the idea that proteins, by themselves, can form a replicating system. As it turns out, there are many, many replicating systems on earth aside from the familiar cellular forms. For starters, consider the controversial nanobacteria that might turn out to be some sort of replicating crystal. Wow!
Life on earth arose from simple molecules that assembled themselves into more and more complex building blocks. And I literally mean "blocks". Watch this amazing movie of replication at the molecular scale to see the machinery of life. You have to make little "machines" out of proteins that fold into specific shapes, and get those machines to mechanically manage the replication process. What you see is a tape consisting of codons (triplet codes) for amino acids. The reader (ribosome) reads the tape and produces a chain of amino acids (protein) that folds itself into a component of a larger machine or an enzyme to enable some reaction. Think about it: the oddly shaped folded pieces are parts, just like those you mill from an aluminum block . The hinges are little crevices and hooks on the parts. The whole thing is driven by an ATP motor. Simply amazing! The ProtocellWhat I want to explore is how a replicating system like this can be created manually and deliberately. I don't mean trying to recreate RNA/DNA/proteins. I mean build a simpler and more elegant thing from scratch. We don't walk around taking movies with squishy eyeballs running on ATP. We build cameras out of plastic, metal, and silicon, and they run on batteries. See what I mean? I want to see a little aluminum/silicon/polymer/light-powered squiggly crawling around under a microscope, having sex, and multiplying.
The FLinT center is doing ground-up development of a "protocell". Here's a quote from their research introduction page:
"The design principle behind our protocell is simple (Rasmussen et al., 2003): Minimize the number and complexity of the physicochemical structures for the required cooperative functionalities. The minimal protocell we seek to implement consists of a particular coupling between the three central components: the genetic material (information), a metabolic system, and a container. Because simplicity is our main goal, we are not restricted to contemporary cellular structures or building blocks." Self-Organizationhttp://mti.msd.anl.gov/highlights/snakes/
In the basement of a nondescript building here at Argonne National Laboratory, nickel particles in a beaker are building themselves into magnetic snakes that may one day give clues about how life originally organized itself.
These chains of metal particles look so much like real, living animals, it is hard not to think of them as alive. (See exclusive video below.) But they are actually bits of metal that came together under the influence of a specially tuned magnetic field.
"It behaves like some live object," says physicist Alex Snezhko. "It moves. It crashes onto free-floating particles and absorbs them."
See my personal attempt to do this experiment using ferrite powder instead of nickel spheres here:
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