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WELCOME TO HOME PAGE OF SRIRAM

D. Sriram

Associate Professor,

Department of Pharmacy,

Birla Institute of Technology & Science-Pilani, Hyderabad Campus,

Jawahar Nagar,

Hyderabad- 500 078.

E-mail: dsriram@bits-hyderabad.ac.in; drdsriram@yahoo.com

Educational Qualifications:

Degree	University	Year	Subjects	Remarks
B.Pharm	The Tamilnadu Dr. M.G.R. Medical University, Chennai, India	1994	Pharmaceutical Sciences	*Gold medalist*
M.Pharm	Banaras Hindu University, Varanasi, India	1997	Medicinal Chemistry	-
Ph.D.	Banaras Hindu University, Varanasi, India	2000	Medicinal Chemistry	*In a record period of 2 Years*

Research Experience:

Drug Discovery, Design and Synthesis of

1. Anti-tubercular drugs (DNA gyrase, Cys M, Cys K₁, Protein kinases, isocitrate lyase etc. inhibitors & Prodrugs)

2. Anti-HIV agents (NNRTIs, & Anti-HIV Prodrugs)

3. C.N.S. Drugs (Neuropathic pain, Epilepsy)

Collaborative Research Scientist at:

1. Karolinska Institute, Sweden.

2. Indian Institute of Science, India.

3. N.I.I. New Delhi, India.

4. Indian Institute of Chemical Technology, India.

5. Madurai Kamaraj University, India.

6. GlaxoSmithKline, Spain.

7. AstraZeneca, India.

Research funding Received: As Principal Investigator

Grant agency	Title of the project	Duration	Amount
UNIVERSITY GRANTS COMMISSION (UGC), NEW DELHI, INDIA	INVESTIGATION ON STRUCTURE-ACTIVITY RELATIONSHIP OF THE QUINOLONE ANTIBACTERIALS AGAINST MYCOBACTERIA	2005-2008	Rs. 5,32,100
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR), NEW DELHI, INDIA	DEVELOPMENT OF NEW GENERATION QUINOLONE MOLECULES AGAINST MYCOBACTERIUM TUBERCULOSIS	2005-2008	Rs. 7,96,000
INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR), NEW DELHI, INDIA	DESIGN AND SYNTHESIS OF NOVEL NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF AIDS AND OPPORTUNISTIC INFECTIONS ASSOCIATED WITH AIDS INCLUDING TUBERCULOSIS	2006-2009	Rs. 11,00,000
DEPARTMENT OF BIOTECHNOLOGY (DBT), NEW DELHI, INDIA	DESIGN AND SYNTHESIS OF INHIBITORS OF VARIOUS ENZYMES OF MYCOBACTERIUM TUBERCULOSIS LIKE DNA GYRASE AND TOPOISOMERASE-I[*DBT CENTRE OF EXCELLENCE PROJECT IN COLLABORATION WITH IISc., BANGALORE*]	2007-2011	Rs. 10.01 Crores
UNIVERSITY GRANTS COMMISSION (UGC), NEW DELHI, INDIA	ISOCITRATE LYASE ENZYME AS TARGET IN PERSISTENT MYCOBACTERIUM TUBERCULOSIS INFECTION	2009-2011	Rs.10,21,800
DEPARTMENT OF BIOTECHNOLOGY (DBT), NEW DELHI, INDIA & VINNOVA, SWEDEN.	STRUCTURE-GUIDED DESIGN OF NEW ANTIBACTERIAL AGENTS AGAINST DORMANT MYCOBACTERIUM TUBERCULOSIS[Indo-Swedish Cooperative Program]	2009-2011	Rs. 64,64,000
OSDD-CSIR,NEW DELHI, INDIA	DESIGN AND SYNTHESIS OF NEW INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLMU BY MODELING & HIGH-THROUGHPUT DOCKING [BITS-NII Collaborative project]	2010-2011	Rs. 43,57,200
ASTRAZENECA	ANTI-TB DRUG DISCOVERY	2010-2012	Rs. 11,11,111
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR), NEW DELHI, INDIA	DEVELOPMENT OF NOVEL DNA GYRASE INHIBITORS AGAINST MYCOBACTERIUM TUBERCULOSIS AND OTHER NON-TUBERCULAR MYCOBACTERIAL INFECTIONS	2010-2013	Rs. 16,98,000
DEPARTMENT OF SCIENCE & TECHNOLOGY [DST],NEW DELHI, INDIA	ANTI-TB DRUG DISCOVERY	2011-2013	Rs. 23,80,000

Ph.D Students Guided / Guiding: Completed: 5 Guiding: 6

1. Dr. R. Thirumurugan (CSIR Senior Research Fellow) : “DESIGN AND SYNTHESIS OF DISUBSTITUTED ARYL SEMICARBAZONES AND ITS ANALOGUES AS ANTICONVULSANTS”-Completed

2. Dr. Tanushree R. Bal (CSIR Senior Research Fellow) : “DESIGN AND SYNTHESIS OF AMINOPYRIMIDINIMINO ISATIN ANALOGUES AS NOVEL NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF AIDS” -Completed

3. Dr. M. Dinakar (UGC Project Fellow): "DEVELOPMENT OF NEWER FUSED QUINOLONE MOLECULES AGAINST MYCOBACTERIUM TUBERCULOSIS"-Completed

4. Dr. P. Senthil Kumar (CSIR Senior Research Fellow): "INVESTIGATION ON STRUCTURE-ACTIVITY RELATIONSHIP OF QUINOLONE DERIVATIVES AGAINST MYCOBACTERIA"- Completed

5. Dr. Debjani Banerjee (ICMR Senior Research Fellow "ISATIN-β-THIOSEMICARBAZONES AS NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF AIDS AND OPPORTUNISTIC INFECTIONS ASSOCIATED WITH AIDS" –Completed

6. Mr. M. Thimmappa (DBT Junior Research Fellow) DEVELOPMENT OF NEWER ISONIAZID DERIVATIVES FOR THE TREATMENT TUBERCULOSIS AND MULTI-DRUG RESISTANT TUBERCULOSIS –Guiding

7. Ms. M. Srividya (UGC Project Fellow): STRUCTURE GUIDED DRUG DESIGN OF ANTI-TB DRUGS–Guiding

8. Mr. Jean Kumar V.U. (DBT Senior Research Fellow): Anti-Tb drug synthesis-Guiding

9. Ms. A. Ramani (Lecturer, BITS-Pilani): Thiazine Derivatives: Synthesis, anti-tubercular activity, pharmacokinetic evaluation and metabolism studies-Guiding

10. Mr Shahul Hammed P (AstraZeneca Research Fellow) Synthesis of varoius heterocyclic compounds for ant-TB activity-Guiding

11. Ms. Mallika A (CSIR Research Associate) Design, synthesis anti-TB drugs-Guiding

M.Pharm/B.Pharm projects guided: ~ 60 projects

Expert Reviewer for the following journals

1. Bioorganic Medicinal Chemistry (Elsevier)

2. Bioorganic Medicinal Chemistry Letters (Elsevier)

3. Letters in Drug Design & Discovery (Bentham)

4. Combinatorial Chemistry & High Throughput Screening (Bentham)

5. Current Enzyme Inhibition (Bentham)

6. Archives der Pharm. Pharm. Med. Chem.

7. Indian Journal of Chemistry, Section B (CSIR)

8. Recent Patents on Anti-infective drug discovery (Bentham)

9. Current Bioactive Agents (Bentham)

10. European Journal of Medicinal chemistry (Elsevier)

11. Journal of Medicinal Chemistry (ACS)

12. Medicinal Chemistry Research

13. Journal of Enzyme Inhibition & Medicinal Chemistry

Professional Recognition, Awards, Fellowships Received:

1.      Recipient of "YOUNG PHARMACY TEACHER OF THE YEAR 2006" awarded by the Association of Pharmacy Teachers of India.

2.      Chief Editor for the new journal International Journal of Drug Design and Discovery.

3.      Editorial Advisory Board Member of the journal, "Recent Patents on Anti-infective Drug Discovery" published by Bentham Science Publishers (USA & The Netherlands).

4.      Life Member of Association of Pharmacy Teachers of India.

5.      Biographical profile included in the prestigious registry of the 6^th edition of “Marquis Who’s Who in Science and Engineering”, 2002-2003 and regularly updated.

6.      Member, Canadian Society of Pharmaceutical Sciences.

7.      Life member, Association of Microbiologist of India.

8.      Recipient of “Sevaratna” Dr. R.Venkatesalu Gold Medal for securing First rank in B.Pharm of The Tamilnadu Dr. M.G.R. Medical University.

9.      Recipient of First Prize award in Tamilnadu State for B.Pharmacy awarded by The Tamilnadu Pharmacy Council, Chennai.

10. Awarded Junior Fellowship by the UGC during the period 1995-1997.

11. Awarded Senior Research Fellowship by the UGC during the period 1998-1999.

Book Published:        1
[“Medicinal Chemistry” 1^st Edition Published in Jan 2007 by PEARSON EDUCATION and 2^nd edition in January 2010]

http://www.pearsoned.co.in/web/books/9788131731444_Medicinal-Chemistry_D--Sriram.aspx

Iam the Chief Editor for the new journal International Journal of Drug Design and Discovery

http://www.ijdddonline.com/

Total Number of Patents filed: 1

Title of the invention: NOVEL N-SPIRO SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF EPILEPSY AND NEUROPATHIC PAIN, Application No.1138/CHE/2009 A

List of published papers

Total Number of Papers Published: 142

Papers in Indian Journals: 6

Papers in International Journals: 136

Scopus citation as on 12th December 2010: 1025

Scopus h index as on 12th December 2010: 23

142. Novel isatinyl derivatives as potential molecule in the crusade against HIV-TB co-infection.

D. Sriram, D. Banerjee, P. Yogeeswari, P. Bhat, A. Thomas.

Eur. J. Med. Chem. 46, 106-121, 2011.

141. Synthesis and antitubercular evaluation of novel substituted aryl and thiophenyl tethered dihydro-6H-quinolin-5-ones.

S. Kantevari, S.R. Patpi, B. Sridhar, P. Yogeeswari, D. Sriram

Bioorg. Med. Chem. Lett. 21, 1214-1217, 2011

140. A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation.

S. U. Maheswari, K. Balamurugan, S. Perumal, P. Yogeeswari, D. Sriram

Bioorg. Med. Chem. Lett. 20, 7278-7282, 2010

139. Facile three-component domino reactions in the regio-selective synthesis and antimycobacterial evaluation of novel indolizines and pyrrolo[2,1-a]isoquinolines"

S. Muthusaravanan, S. Perumal,P. Yogeeswari, D. Sriram

Tetrahedron Letters 51, 6439-6443, 2010.

138. A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiropyrrolothiazolyloxindoles and their antitubercular evaluation.

P. Prasanna, K. Balamurugan, S. Perumal, P. Yogeeswari, D. Sriram

Eur. J. Med. Chem. 45, 5653-5661, 2010.

137. 5-Nitro-2,6-dioxohexahydro-4-pyrimidinecarboxamides: Synthesis and antimycobacterial activities.

D. Sriram, P. Yogeeswari, P. Senthilkumar, G. Naidu

J. Enz. Inhib. Med. Chem., 25, 765-772, 2010.

136. Synthesis and antitubercular activities of substituted benzoic acid N'-(substituted benzylidene/furan-2-ylmethylene)-N- (pyridine-3-carbonyl)-hydrazides.

P. Kumar, B. Narasimhan, D. Sharma, P. Yogeeswari, D. Sriram

Eur. J. Med. Chem. 45, 6085-6089, 2010.

135. Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity.

R. Manikannan, S. Muthusubramanian, P. Yogeeswari, and D. Sriram

Bioorg. Med. Chem. Lett. 20, 6920-6924, 2010.

134. 1,3-Dipolar cycloaddition of nitrile oxides to (R)-1-(1-phenylethyl)-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: Synthesis and antimycobacterial evaluation of novel enantiomerically pure di- and trispiroheterocycles.

R.S. Kumar, S.M. Rajesh, S. Perumal, P. Yogeeswari, D. Sriram.

Terahedron Asymmtry, 21, 1315-1327, 2010.

133. Antiallodynic and antihyperalgesic activities of anticonvulsant gaba derivatives in both sciatic nerve and spinal nerve ligation models of neuropathic pain

P. Yogeeswaria, A. Semwal, D. Sriram, J.V. Ragavendran, N. Sreevatsan, S. Monika

Pharmacologyonline, 2, 634-647, 2010.

132. 5-Nitro-2-furoic acid hydrazones: Design, synthesis and in-vitro antimycobacterial evaluation against log and starved phase cultures.

D. Sriram, P. Yogeeswari, D. R.i K. Vyas, P. Senthilkumar, P. Bhat, M. Srividya.

Bioorg. Med. Chem. Lett. 20, 4313-4316, 2010.

131. A facile synthesis and discovery of highly functionalized tetrahydropyridines and pyridines as antimycobacterial agents.

R. S. Kumar, S. M. Rajesh, S. Perumal, D. Banerjee, P. Yogeeswari and D. Sriram.

Chem. Pharm. Bull. 58, 602-610, 2010.

130. Aromatic Amino Analogues of Artemisinin: Synthesis and In-vivo Antimalarial Activity.

D. Sriram, R. V. Devakaram, M. Dinakaran, P. Yogeeswari.

Med. Chem. Res. 19, 524-532, 2010.

129. Discovery of Isatinimino Derivatives as New Leads for Neuropathic Pain Treatment: An Isomeric Modification Approach

Semwal, P. Yogeeswari, J. V. Ragavendran, D. Sriram, J. Stables

Int. J. Drug Des. & Discov., 1, 65-80, 2010.

128. Synthesis and antimycobacterial evaluation of novel phthalazin-4-ylacetamides against log- and starved phase cultures.

D. Sriram, P.Yogeeswari, P. Senthilkumar, D. Sangaraju, R. Nelli, D. Banerjee, P. Bhat, T.H Manjashetty.

Chem. Biol. & Drug Design, 75, 381-391, 2010.

127. Effectiveness of antiepileptic GABA analogues for the treatment of neuropathic pain

P. Yogeeswari, J. V. Ragavendran, D. Sriram, A. Priyanka, S. Ganguly, A. Sunil Kumar Reddy, Arvind Semwal

Pharmacologyonline 1, 575-590, 2010.

126. Selective one-pot multicomponent synthesis and antitubercular evaluation of 5-(aryl/cyclohexylsulfanyl)-2-alkoxy-4,6-diarylnicotinonitriles.

R. Manikannan, S. Muthusubramanian, P. Yogeeswari and D. Sriram.

Bioorg. Med. Chem. Lett., 20, 3352-3355, 2010.

125. A microwave-assisted, facile, regioselective Friedländer synthesis and antitubercular evaluation of 2,9-diaryl-2,3-dihydrothieno-[3,2-b]quinolines.

K. Balamurugan, V. Jeyachandran, S. Perumal, T. H. Manjashetty, P. Yogeeswari, D. Sriram

Eur. J. Med. Chem. 45, 682-688, 2010.

124. Synthesis, in-vitro evaluation and computational studies of novel isatinyl derivatives for their activity against HIV-TB co-infection.

D. Banerjee, P. Yogeeswari, P. Bhat, D. Sriram.

Int. J. Drug Des. & Discov., 1, 65-80, 2010.

123. A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazolesas antitubercular agents.

S. V. Karthikeyan, B. D. Bala, V. P. A. Raja, S. Perumal, P. Yogeeswari, D. Sriram.

Bioorg. Med. Chem. Lett., 20, 350-353, 2010.

122. Discovery of Newer Antitubercular 2,10-Dihydro-4aH-chromeno[3,2-c]pyridin-3-yl Derivatives.

D. Sriram, P. Yogeeswari, M. Dinakaran, D. Banerjee, P. Bhat, S. Gadhwal

Eur. J. Med. Chem. 45, 120-123, 2010.

121. 1,3-Dipolar cycloaddition of C-aryl-N-phenylnitrones to (R)-1-(1-phenylethyl)-3-[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: Synthesis and antimycobacterial evaluation of enantiomerically pure spiroisoxazolidines.

R. S. Kumar, S. Perumal, K. A. Shetty, P. Yogeeswari, D. Sriram.

Eur. J. Med. Chem. 45, 124-133, 2010.

120. Novel three-component domino reactions of ketones, isatin and amino acids: Synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines.

R. S. Kumar, S. Perumal, D. Banerjee, P. Yogeeswari, D. Sriram.

Eur. J. Med. Chem. 45, 411-422, 2010.

119. 5-Nitrothiazolylthiosemicarbazones: Synthesis and antimycobacterial evaluation against tubercular and non-tubercular mycobacterial species.

D. Sriram, P. Yogeeswari, P. Senthilkumar, S. Dewakar.

J. Enzyme Inhib. Med. Chem., 25, 105-110, 2010.

118. l-Proline-catalysed facile green protocol for the synthesis and antimycobacterial evaluation of [1,4]-thiazines.

S. Indumathi, S. Perumal, D. Banerjee, P, Yogeeswari, D. Sriram.

Eur. J. Med. Chem., 44, 4978-4984, 2009.

117. A facile domino protocol for the regioselective synthesis and discovery of novel 2-amino-5-arylthieno-[2,3-b]thiophenes as antimycobacterial agents.

K. Balamurugan, S. Perumal, A. S. K. Reddy, P. Yogeeswari, D. Sriram.

Tetrahedron Letters, 50, 6191-6195, 2009.

116. The anti-HIV-1 and antibacterial activities of two novel AZT-fuoroquinolones conjugates.

J. Long, D. Sriram, G.H. Zhang, Y.T. Zheng.

Chinese Pharmacological Bulletin 25, 30-34, 2009.

115. Novlel pthalazinyl derivatives: Synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis isocitrate lyase enzyme.

D. Sriram, P.Yogeeswari, P. Senthilkumar, D. Sangaraju, R. Nelli, D. Banerjee, P. Bhat, B. Veugopal, V.V. S. Pavan, T.H Manjashetty.

Med. Chem., 5, 422-433, 2009.

114. Current Approaches with the Glutamatergic System as Targets in the Treatment of Neuropathic Pain.

P. Yogeeswari, Arvind Semwal, Ram Kumar Mishra, D. Sriram.

Expert Opinion on Therapeutic Targets, 13, 925-943, 2009.

113. A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines.

R. R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram.

Eur. J. Med. Chem. 44, 3821-3829, 2009.

112. An atom economic synthesis and antitubercular evaluation of novel spiro-cyclohexanones R. R. Kumar, S. Perumal, S. C. Manju, P. Bhat, P. Yogeeswari, D. Sriram.

Bioorg. Med. Chem. Lett. 19, 3461-3465, 2009.

111. A microwave assisted facile regioselective Fischer Indole synthesis and antitubercular evaluation of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles.

S. V. Karthikeyan,S. Perumal,Krithika A. S.,P. Yogeeswari, D. Sriramand K. K. Balasubramanian.

Bioorg. Med. Chem. Lett. 19, 3006-3009, 2009.

110. Synthesis of zidovudine derivatives with anti-HIV-1 and antibacterial activities.

P. Senthilkumar, J. Long, R. Swetha, V. Shruthi, R.Wang, S. Preethi, P. Yogeeswari, Y.T. Zheng,D. Sriram.

Nucleosides, Nucleotides, & Nucleic Acids, 28, 89-102, 2009.

109. Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids.

P. Senthilkumar, M. Dinakaran, P. Yogeeswari, D. Sriram, A. China, V. Nagaraja.

Eur J Med Chem. 44, 345-358, 2009.

108. 5-Nitrofuran-2-yl derivatives: Synthesis and inhibitory activities against growing and dormant mycobacterium species.

D. Sriram, P. Yogeeswari, P. Dhakla, P. Senthilkumar, D. Banerjee, T.H. Manjashetty.

Bioorg. Med. Chem. Lett. 19, 1152-1154, 2009.

107. Antimycobacterial activity of novel N-(substituted)-2-isonicotinoylhydrazinocarbothioamide endowed with high activity towards isoniazid resistant tuberculosis.

D. Sriram, P. Yogeeswari, Y. Priya.

Biomed. Pharmacother. 63, 36-39, 2009.

106. Efavirenz Mannich bases: Synthesis, anti-HIV and anitubercular activities.

D. Sriram, D. Banerjee, P. Yogeeswari.

J. Enzyme Inhib. Med. Chem. 24, 1-5, 2009.

105. Antitubercular activities of novel benzothiazolo naphthyridone carboxylic acid derivatives endowed with high activity toward multi-drug resistant tuberculosis.

M. Dinakaran, P. Senthilkumar, P. Yogeeswari, D. Sriram.

Biomed. Pharmacother. 63, 11-18, 2009.

104. Synthesis and In-vitro Antimycobacterial Evaluation of Newer 1-(cyclopropyl/2,4-difluorophenyl/t-butyl)-1,4-dihydro-8-methyl-6-nitro-4-oxo-7-(substituted secondary amino)-quinoline-3-carboxylic acids.

P. Senthilkumar, M. Dinakaran, Y. Chandraseakaran, P. Yogeeswari, D. Sriram.

Arch. Pharm. 342, 100-112, 2009.

103. Antimycobacterial activities of novel fluoroquinolones.

P. Senthilkumar, M. Dinakaran, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram.

Biomed. Pharmacother. 63, 27-35, 2009.

102. Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one.

M. Shalini, P. Yogeeswari, D. Sriram, J.P. Stables.

Biomed. Pharmacother. 63, 187-193, 2009.

101. A highly atom economic, chemo-, regio- and stereoselective synthesis, and discovery of spiro-pyrido-pyrrolizines and pyrrolidines as antimycobacterial agents.

R.R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram.

Tetrahedron, 64, 2962-2971, 2008.

100. Discovery of antimycobacterial spiro-piperidin-4-ones: an atom economic, stereoselective synthesis, and biological intervention.

R.R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram.

J. Med. Chem. 51, 5731-5735, 2008.

99. Synthesis, antimycobacterial activities and phototoxic evaluation of 5H-thiazolo[3,2-a]quinoline-4-carboxylic acid derivatives.

M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram.

Med. Chem. 4, 482-491, 2008.

98. Newer N-phthaloyl GABA derivatives with antiallodynic and antihyperalgesic activities in both sciatic nerve and spinal nerve ligation models of neuropathic pain.

P. Yogeeswari, J.V. Ragavendran, D. Sriram, R. Kavya, K. Vanitha, H. Neelakantan.

Pharmacology., 81, 21-31, 2008.

97. Synthesis, anti-HIV and antitubercular activities of nelfinavir diester derivatives.

D. Sriram, P. Yogeeswari, M. Dinakaran, M. Sowmya.

Biomed. Pharmacother., 62, 1-5, 2008.

96. Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids.

P. Senthilkumar, M. Dinakaran, D. Banerjee, R.V. Devakaram, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram.

Bioorg. Med. Chem., 16, 2558-2569, 2008.

95. Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a] quinoline-6-carboxylic acid.

M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram.

Bioorg Med Chem., 16, 3408-3418, 2008.

94. Antimycobacterial and phototoxic evaluation of novel 6-fluoro/nitro-4-oxo-7-(sub)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid.

M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram.

Int. J. Antimicrob. Agents., 31, 337-344, 2008.

93. N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo.

L. Sebastian, A. Desai, M.N. Shampur, P. Yogeeswari, D. Sriram, Vasanthapuram R.

Virol. J., 5:64, 2008.

92. Newer GABA derivatives for the treatment of epilepsy including febrile seizures: A bioisosteric approach.

Ragavendran J.V., Sriram D, Kotapati S, Stables J, Yogeeswari P.

Eur. J..Med. Chem., 43, 2650-2655, 2008.

91. Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation.

M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram.

Bioorg. Med. Chem. Lett. 18, 1229-1236, 2008.

90. Antimycobacterial activities of novel 1-(cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro- 6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic acid.

D. Sriram, P. Senthilkumar, M. Dinakaran, P. Yogeeswari, A. China, V. Nagaraja.

J. Med. Chem., 50, 6232-6239, 2007.

89. Heteroaryl-substituted semicarbazones: Synthesis and anticonvulsant activity of N-(3-Methylpyridin-2-yl)-substituted semicarbazones.

S. Mehta, P. Yogeeswari, Roheeth Kumar, D. Sriram.

J. Het. Chem., 43, 1287-1293, 2007.

88. Antimycobacterial activity of novel 1-(5-cyclobutyl-1,3-oxazol-2-yl)-3-(sub)phenyl/pyridylthiourea endowed with high activity toward multi-drug resistant tuberculosis.

D. Sriram, P. Yogeeswari, M. Dinakaran, R. Thirumurugan.

J. Antimicrob. Chemother. 59, 1194-1196, 2007.

87. Discovery of 4-Aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: A Hybrid pharmacophore approach.

P. Yogeeswari, J. Vaigunda Ragavendran, D. Sriram, Y. Nageswari, R. Kavya, N. Sreevatsan, K. Vanitha, J. Stables.

J. Med. Chem., 50, 2459-2467, 2007.

86. Synthesis and Antimicrobial Activities of Some Novel Substituted 2-Imidazolyl-N-(4-oxo-quinazolin-3(4H)-yl)-acetamides.

N.M. Raghavendra, P. Thampi, P.M. Gurubasavarajaswamy, D. Sriram

Chem. Pharm. Bull. 55, 1615-1619, 2007.

85. An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles.

R.R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram

Bioorg. Med. Chem. Lett. 17, 6459-6462, 2007.

84. Synthesis, antitubercular and anticancer activities of substituted furyl-quinazolin-3(4H)-ones.

N.M. Raghavendra, P. Thampi, P.M. Gurubasavarajaswamy, D. Sriram.

Arch. Pharm. 340, 635-641, 2007.

83. Synthesis and antitubercular activities of 1-(cyclopropyl/t-butyl/4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxo-7-(substituted secondary amines)-1,8-naphthyridine-3-carboxylic acid.

P. Senthil Kumar, M. Dinakaran, P. Yogeeswari, D. Sriram.

Med. Chem. Res., 15, 281-282, 2007.

82. N-Hydroxythiosemicarbazones: Synthesis and in-vitro antitubercular activity.

D. Sriram, P. Yogeeswari, Prathiba Dakhla, P. Senthil Kumar, Debjani Banerjee.

Bioorg. Med. Chem. Lett., 17, 1888-1893, 2007.

81. Isatin derivatives inhibit Japanese encephalitis virus entry and replication in-vitro.

D. Banerjee, T.R. Bal, P. Yogeeswari, D. Sriram, L. Sebastin, A. Desai, S.N. Madhusudhana, V. Ravi.

Med. Chem. Res., 15, 133-135, 2007.

80. Microwave-assisted Synthesis, Anticonvulsant activity and Quantum Mechanical modeling of N-(4-Bromo-3-methylphenyl)semicarbazones.

Shalini, P. Yogeeswari, D. Sriram, S. Induja.

J. Zhejiang Univ. Section B (Springer), 8, 45-55, 2007.

79. Synthesis of 4-{[(3Z)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]amino}-N-substituted phenyl) butanamides possessing antiallodynic and antihyperalgersic activities in two rat models of neuropathic pain.

J.V. Ragavendran, I. Vikram Reddy, P. Yogeeswari, D. Sriram.

Med. Chem. Res., 15, 225-226, 2007.

78. Design and Synthesis of Anticonvulsants from a Combined Phthalimide-GABA –Anilide and Hydrazone Pharmacophore.

J. V. Ragavendran, D. Sriram, S.K. Patel, I. Vikram Reddy, N. Bharathwajan, J. Stables, P. Yogeeswari.

Eur. J. Med. Chem., 42, 146-151, 2007.

77. Neuropathic pain: Strategies in drug discovery and treatment.

P. Yogeeswari, J.V. Ragavendran, D. Sriram.

Expert Opinion on Drug Discovery, 2, 169-184, 2007.

76. 5-Nitro-2-furaldehyde thiosemicarbazones: Synthesis and in-vitro antimycobacterial activities.

K.N. Purna, P. Dhakla, P. Senthil Kumar, P. Yogeeswari, D. Sriram.

Med. Chem. Res., 15, 223-224, 2007.

75. Synthesis of various 7-substituted-1-t-butyl-1,4-dihydro-8-methyl-6-nitro-4-oxo quiniline-3-carboxylic acid.

M. Dinakaran, C. Yogesh, P. Yogeeswari, D. Sriram.

Med. Chem. Res., 15, 328, 2007.

74. Newer Tetracycline derivatives: Synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase.

D. Sriram, P. Yogeeswari, G. Senchani, D. Banerjee.

Bioorg. Med. Chem. Lett.,17, 2372-2375, 2007.

73. Synthesis and in-vitro anti-HIV activities of Didanosine prodrugs.

D. Sriram, P. Yogeeswari, N. Raveendra Babu, K.N. Purna.

J. Enzyme Inhib.Med. Chem.,22, 51-55, 2007.

72. Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: A Pharmacophoric hybrid approach.

P. Yogeeswari, D. Sriram, P. Sahitya, J.V. Ragavendran, V. Ranganadh.

Bioorg. Med. Chem. Lett., 17, 3712-3715, 2007.

71. Pharmacological screening of candidate anticonvulsants in the animal model of febrile seizures.

A.S.K. Reddy, J.V. Ragavendran, P. Yogeeswari, D. Sriram.

Med. Chem. Res., 15, 285-286, 2007.

70. Synthesis and anti-HIV activity of N'-nicotinoyl--3-(4'-hydroxy-3'-methylphenyl)-5-[substituted phenyl]-2-pyrazolines.

M.A. Ali, M.S. Yar, A.A. Siddiqui, D. Sriram, P. Yogeeswari, E. De Clercq.

Acta. Pol. Pharm., 64, 423-428, 2007.

69. Discovery of lesser neurotoxic and effective anticonvulsant agents active in four animal models of seizure.

D. Sriram, M. Shalini.

Neurol. Asia, 12, 111-112, 2007.

68. Synthesis and anti-HIV activity of nevirapine prodrugs.

D. Sriram, P. Yogeeswari, M.R. Kishore

Pharmazie., 61, 895-897, 2006.

67. Synthesis and antimicrobial activity of 3-(4'-hydroxy-3'-methylphenyl)-5-[(substuted) phenyl]-4,5-dihydro-1H-1-pyrazolyl-4-pyridylmethanone derivatives.

M.S. Yar, M.A. Ali, D. Sriram, P. Yogeeswari.

Acta. Pol. Pharm., 63, 491-496, 2006.

66. Quantum mechanical modeling of N4-(2, 5-disubstituted phenyl) semicarbazones: synthesis and anticonvulsant activity of N4-(2, 5-dimethylphenyl/ -2-fluoro-5-methyl phenyl) semicarbazones.

M. Shalini, P. Yogeeswari, D. Sriram, P. Kudyar, P.R. Kumar, S. Induja, J.P. Stables

Med. Chem., 2, 617-625, 2006.

65. Discovery of Newer Antitubercular Oxazolyl thiosemicarbazones.

D. Sriram, P. Yogeeswari, R. Thirumurugan, P. Roheeth Kumar.

J. Med. Chem. 49, 3448-3450, 2006.

64. Synthesis and in-vitro antitubercular activity of some 1-[(4-sub)phenyl]- 3-(4-{1- [(pyridine-4-carbonyl)hydrazono]ethyl phenyl) thiourea.

D. Sriram, P. Yogeeswari, K. Madhu.

Bioorg. Med. Chem. Lett. 16, 876-878, 2006.

63. Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides.

D. Sriram, P. Yogeeswari, R.V. Devakaram.

Bioorg. Med. Chem., 14, 3113-3118, 2006.

62. Synthesis of Pyrazinamide Mannich bases and its antitubercular properties.

D. Sriram, P. Yogeeswari, S.P. Reddy

Bioorg. Med. Chem. Lett., 16, 2113-2116, 2006.

61. Gatifloxacin derivatives: Synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase.

D. Sriram, A. Aubry, P. Yogeeswari, L.M. Fischer.

Bioorg. Med. Chem. Lett., 16, 2982-2985, 2006.

60. Design, synthesis, anti-HIV and antitubercular activities of isatin derivatives.

D. Sriram, P. Yogeeswari, K. Meena.

Pharmazie, 61, 271-274, 2006.

59. An Update on GABA Analogs for CNS Drug Discovery.

P. Yogeeswari, J.V. Ragavendran, D. Sriram.

Recent Patent on CNS Drug Discov., Vol 1 (First issue) 113-118, 2006.

58. Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones.

P. Yogeeswari, D. Sriram, J. Vaigunda Raghavendran, R. Thirumurugan, S. Induja, J.P. Stables.

Med. Chem., 2, 55-62, 2006.

57. 2,4-Dimethoxyphenyl semicarbazones with anticonvulsant activity against three animal models of seizure: Synthesis and Pharmacological evaluation

P. Yogeeswari, D. Sriram, R. Thirumurugan, J.P. Stables

Bioorg. Med. Chem., 14, 3106-3112, 2006.

56. Epibatidine and its analogues as nicotinic acetylcholine receptor agonist. An update.

P. Yogeeswari, D. Sriram, R.Thirumurugan, T. R. Bal

Nat. Prod. Res., 20, 497-505, 2006.

55. Synthesis of some new semicarbazone derivatives as anticonvulsants with GABA- mediated mechanism.

P. Yogeeswari, R.Thirumurugan, D. Sriram, L.R.J. Suniljit, J. Vaigunda Ragavendran, R. Kavya, K. Rakhra, J.P. Stables.

Acta. Pharm., 56, 259-272, 2006.

54. Synthesis and in-vitro antimycobacterial activity of N¹-Nicotinoyl-3-(4’-hydroxy-3’-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines.

M. Shaharyar, A.A. Siddiqui, M. Asharaf Ali, D. Sriram, P. Yogeeswari.

Bioorg. Med. Chem. Lett., 16, 3947-3949, 2006.

53. Abacavir prodrugs: Microwave-assisted synthesis and their evaluation of anti-HIV activities.

D. Sriram, P. Yogeeswari, N.S. Myneedu, V. Saraswat.

Bioorg. Med. Chem. Lett., 16, 2127-2129, 2006.

52. Evaluation of antimycobacterial and DNA gyrase inhibition of fluoroquinolone derivatives.

D. Sriram, T. R. Bal, P. Yogeeswari, D.R. Radha, V. Nagaraja.

J. Gen. App. Microbiol., 52, 195-200, 2006.

51. Discovery of N-(2,6-Dimethylphenyl) substituted Semicarbazones as Anticonvulsants : Hybrid Pharmacophore-based design

P. Yogeeswari, D. Sriram, R. Thirumurugan, J.V. Raghavendran, K. Sudhan, Roheeth Kumar, J. Stables.

J. Med. Chem., 48, 6202-6211, 2005.

50. Aminopyrimidinimino isatin analogues: Design and synthesis of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum anti-microbial properties

D. Sriram, T. R. Bal, P. Yogeeswari.

Med. Chem., 1, 277-285, 2005.

49. Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: Design, synthesis and biological evaluation.

D. Sriram, T. R. Bal, P. Yogeeswari.

Farmaco, 60, 377-384, 2005.

48. The GABA shunt: An attractive and potential therapeutic target in the treatment of epileptic disorders.

P. Yogeeswari, D. Sriram, J.V. Raghavendran, R. Thirumurugan.

Curr. Drug Metabolism, 6, 127-140, 2005.

47. Combinatorial Synthesis of anti-HIV-1 agents.

D. Sriram, P.Yogeeswari, A.N. Nagappa.

Comb. Chem. High Throughput Screen., 8(6), 377-385, 2005.

46. Camptothecin and its analogues: A review on their chemotherapeutic potential.

D. Sriram, P. Yogeeswari, R.Thirumurugan, T. R. Bal.

Nat. Prod. Res., 19, 393-412, 2005.

45. Synthesis of Novel Aryl semicarbazones as Potential Anticonvulsant Agents.

P.Yogeeswari, D. Sriram, V.Veena, R.Kavya, K.Rakhra, S.Mehta, J.VaigundaRagavendran, R.Thirumurugan, J.P.Stables.

Biomed. Pharmacother., 59, 51-55, 2005.

44. Anticonvulsant and neurotoxicity evaluation of some 6-substituted benzothiazolyl-2-thiosemicarbazones.

P. Yogeeswari, D. Sriram, S. Mehta, D. Nigam, M. Mohan Kumar, S. Murugesan, J.P. Stables.

Farmaco, 60 (1), 1-5, 2005.

43. Betulinic acid and its derivatives: A review on their biological properties.

P. Yogeeswari and D. Sriram

Curr. Med. Chem., 12 (3), 763-771, 2005.

42. Synthesis and Antimycobacterial evaluation of various 7- Substituted Ciprofloxacin Derivatives

D. Sriram, P. Yogeeswari, J.S. Basha, D. R. Radha, V. Nagaraja.

Bioorg. Med. Chem., 13, 5774-5778, 2005.

41. Synthesis and in-vitro antimycobacterial activity of some isonicotinyl hydrazones.

D. Sriram, P. Yogeewari and K. Madhu.

Bioorg. Med. Chem. Lett., 15, 4502-4505, 2005.

40. Synthesis and evaluation of anti-HIV activity of isatin b-thiosemicarbazone derivatives.

T.R. Bal, B. Anand, P. Yogeeswari, D. Sriram.

Bioorg. Med. Chem. Lett., 15, 4451-4455, 2005.

39. Microwave-assisted synthesis, and anti-YFV activity of 2, 3-diaryl-1, 3-thiazolidin-4-ones

D. Sriram, P. Yogeeswari, T.G. Ashok Kumar

J. Pharm. Pharm. Sci., 8, 429-466, 2005.

38. Synthesis of zidovudine prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS.

D. Sriram, P. Yogeeswari, N. Srichakravarthy, T. R. Bal.

Biomed. Pharmacother. 59, 452-455, 2005.

37. Nevirapine derivatives with broad spectrum chemotherapeutic properties for the effective treatment of HIV / AIDS.

D. Sriram, P. Yogeeswari, N. Srichakravarthy, T. R. Bal.

Biomed. Pharmacother., 59, 456-459, 2005.

36. Microwave-assisted synthesis, anti-HIV activity of 2, 3-diaryl-1, 3-thiazolidin-4-ones.

D. Sriram, P. Yogeeswari, T.G. Ashok Kumar.

Ind. J. Pharm. Sci., 67, 496-499, 2005.

35. Microwave Assisted Synthesis, Anti-HIV, and Anti-YFV Activities of Schiff Bases of N-Hydroxy-N¹-Aminoguanidine tosylate.

D. Sriram, P. Yogeeswari, T.G. Ashok Kumar.

Ind. J. Pharm. Sci., 67, 493-496, 2005.

34. Aminopyrimidinimino isatin analogues: Design of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties.

D. Sriram, T. R. Bal, P. Yogeeswari.

J. Pharm. Pharm. Sci., 8, 565-577, 2005.

33. Synthesis and in-vitro cytotoxicity evaluation of gatifloxacin Mannich bases.

P. Yogeeswari, D. Sriram, R. Kavya, S. Tiwari.

Biomed. Pharmacother., 59, 501-510, 2005.

32. Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs.

D. Sriram, P. Yogeeswari, Gayatri Gopal.

Eur. J. Med. Chem., 40, 1373-1376, 2005.

31. Design, synthesis and biological evaluation of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum antimicrobial properties: Aminopyrimidinimino isatin analogues.

D. Sriram, T. R. Bal, P. Yogeeswari.

Med. Chem. Res., 14, 211-228, 2005.

30. Progress in the research of artemisinin and its analogues as anti-malarials: an update

D. Sriram, V. S. Rao, K. V. G. Chandrasekhar and P. Yogeeswari.

Nat. Prod. Res., 18(6), 503-527, 2004.

29. Design, synthesis and biological evaluation of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties.

D. Sriram, T. R. Bal, P. Yogeeswari.

Bioorg. Med. Chem., 12, 5865-5873, 2004.

28. Ion channels as important targets for antiepileptic drug design.

P.Yogeeswari, J. Vaigunda Raghavendran, R. Thirumurugan, A. Saxena. , D. Sriram.

Curr. Drug Targets, 5, 589-602, 2004.

27. Antituberculous activity of some aryl semicarbazones derivatives.

D. Sriram, P. Yogeeswari, R. Thirumurugan.

Bioorg. Med. Chem. Lett., 15, 3923-3924, 2004.

26. 4-Sulphamoylphenyl semicarbazones with anticonvulsant activity.

P. Yogeeswari, D. Sriram, S.N. Pandeya, J.P. Stables.

Farmaco, 59, 609-613, 2004.

25. 2-Methyl, 3-chlorophenyl-substituted semicarbazones: Synthesis and anticonvulsant activity.

P. Yogeeswari, R. Thirumurugan, R. Kavya, J. Selwyn Samuel, J.P. Stables, D. Sriram.

Eur. J. Med. Chem., 39, 729-734, 2004.

24. Synthesis of Tetrahydro-2H-[1, 3, 5] thiadiazine-5-(4-pyridylcarboxamido)-2-thione with antitubercular activity.

D. Sriram, K. Jyothi Mallika and P. Yogeeswari.

Sci. Pharm., 75, 35-41, 2004.

23. Synthesis of Stavudine Amino acid Ester Prodrugs with Broad-Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV/AIDS.

D. Sriram, P. Yogeeeswari, N. Srichakravarthy, Tanushree Ratan Bal.

Bioorg. Med. Chem. Lett., 14, 1085-1087, 2004.

22. Synthesis of novel aryl semicarbazones as anticonvulsants with GABA-mediated mechanism.

P.Yogeeswari, D. Sriram, A.Brahmandam,I.Sridharan, R.Thirumurugan and J.P. Stables.

Med. Chem. Res., 12(2), 57-68, 2003.

21. Synthesis and Anticonvulsant and Neurotoxicity Evaluation of N⁴ –Phthalimido Phenyl (Thio) Semicarbazides.

P.Yogeeswari, D. Sriram, V.Saraswat, J.Vaigunda Ragavendran, M.Mohan Kumar, S.Murugesan, R.Thirumurugan, J.P.Stables.

Eur. J. Pharm. Sci., 20, 341-346, 2003.

20. Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS.

D. Sriram, P.Yogeeswari.

Curr. Med. Chem., 10, 1909-1915, 2003.

19. Antibacterial and antifungal activities of N-Mannich bases of 3-[N²-pyrimethaminylimino] isatin.

S.N.Pandeya, P.Yogeeswari, D. Sriram, G.Nath.

Ind. J. Pharm. Sci., 64, 209-212, 2002.

18. Antituberculous activity of isatin derivatives.

D. Sriram, P.Yogeeswari, S.N.Pandeya, S. Ananthan.

Sci. Pharm., 70, 73-79, 2002.

17. Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones.

P.Yogeeswari, D. Sriram, L.R.J. Suniljit, S.S.Kumar, J.P.Stables.

Eur. J. Med. Chem., 37, 231-236, 2002.

16. Antituberculous activity of Norfloxacin Mannich bases with Isatin derivatives.

S.N. Pandeya, D. Sriram, P.Yogeeswari, S. Ananthan.

Chemotherapy, 47, 266-269, 2001.

15. Anticonvulsant and Neurotoxicity evaluation of 5-(un)-substituted isatinimino derivatives.

S.N.Pandeya, D. Sriram, P.Yogeeswari, J.P. Stables.

Pharmazie, 56, 875-878, 2001.

14. Anti-HIV and antibacterial activities of some disubstituted quinazolones and their Bio-isostere Disubstituted thienopyrimidones.

V. Alagarsamy, U.S. Pathak, D. Sriram, S.N. Pandeya, E. De Clercq.

Ind. J.Pharm Sci. 62(6), 433-437, 2000.

13. Synthesis, antibacterial, antifungal and anti-HIV activity of Schiff and Mannich bases of Isatin with N- [6-chlorobenzothiazol-2-yl] thiosemicarbazide.

S.N. Pandeya, D. Sriram, G. Nath, E. De Clercq.

Ind. J. Pharm Sci. 61(6). 358-361, 2000.

12. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of Isatin and its derivatives with Triazole.

S.N. Pandeya, D. Sriram, G.Nath, E.De Clercq.

Arzneim-Forsch./Drug Res. 50(1), 55-59, 2000.

11. Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin Mannich bases.

S.N. Pandeya, D. Sriram, G. Nath, E.De Clercq.

Eur, J. Med. Chem. 35, 249-265, 2000.

10. Synthesis and antimicrobial activity of Schiff and Mannich bases of Isatin and its derivatives with pyrimidine.

S.N.Pandeya, D. Sriram, G.Nath, E.De Clercq.

Farmaco, 54, 624-628, 1999.

9. Synthesis and Screening for Anti-HIV activity of some N-Mannich bases of isatin derivatives.

S.N. Pandeya, P.Yogeeswari, D. Sriram, E. De Clercq, C. Pannecouque, M. Witvrouw.

Chemotherapy, 45, 192-196, 1999.

8. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methyl mercapto quinazolin –4(3H)- one.

S.N. Pandeya, D. Sriram, G.Nath, E.De Clercq.

Pharm. Act. Helv., 74, 11-17, 1999.

7. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Norfloxacin Mannich bases.

S.N. Pandeya, D. Sriram, G.Nath, E.De Clercq.

Sci. Pharm. 67, 103-111, 1999.

6. Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4’-Chlorophenyl) thiazol-2-yl] thiosemicarbazide.

S.N. Pandeya, D. Sriram, G. Nath, E.De Clercq.

Eur. J. Pharm. Sci. 9, 25-31, 1999.

5. Synthesis and evaluation of some novel Schiff’s and Mannich bases of Indole-2,3-diones as potential antibacterial, analgesic and anti-inflammatory agents.

S.N.Pandeya, D. Sriram, V.Alagarsamy.

Acta Pharm. Turc. XLI(4), 153-158, 1999.

4. Synthesis and antibacterial activity of Mannich bases of Ciprofloxacin and Lomefloxacin with Isatin and its derivative.

S.N.Pandeya, C.G.Sundari, N.Mariammal, P.Saravanan, S.S. Balaji, R.S.Kumar, D. Sriram.

Ind. J. Pharm. Sci. 60(5), 280-282, 1998.

3. Synthesis and screening for antibacterial activity of Schiff’s and Mannich bases of Isatin and its derivatives.

S.N.Pandeya, D. Sriram.

Acta Pharm. Turc. 40(10), 33-38, 1998.

2. Synthesis and antimicrobial activity of N-Mannich bases of 3-[N’-sulphadoximino] Isatin and its methyl derivative.

S.N.Pandeya, P.Yogeeswari, D. Sriram, G.Nath.

Boll. Chim. Farm. 137(8), 321-324, 1998.

1. Anti-HIV activity of some Mannich bases of isatin derivatives.

S.N. Pandeya, D. Sriram, E. De Clercq; C. Pannecouque, M. Witvrouw.

Ind. J. Pharm. Sci. 60(4), 207-212, 1998.

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