Computational work is felt to be more of an art than a science.  Personal: I was born in July 1981, Nanjing, P. R. China. I was educated in the same city, initially at Nanjing University of Science and Technology, and then at Nanjing University, where I read chemistry and conducted doctoral research with Prof. Shuhua Li. I had postdoctoral training in Prof. Huan-Xiang Zhou's group at Florida State University for 3 years, where I mainly worked on membrane proteins. I am now a postdoctoral fellow in Prof. Michael L. Klein's group at Temple University. I maintain a steady interest in understanding general questions in both chemical and biological systems by using multi-scale computational methods. Email: donghaonj@gmail.com Office: Bio-Life 106F, 1900 N 12th Street, Philadelphia, PA 19122 Phone: (215) 204-4221 (office) Experience:  2012.1 ~ present Postdoctoral Fellow Institute for Computational Molecular Science (ICMS), Temple University, Philadelphia, PA Supervisor: Prof. Michael L. Klein  2009.1 ~ 2011.12 Postdoctoral Research Associate Institute of Molecular Biophysics (IMB) & Department of Physics, Florida State University, Tallahassee, FL Supervisor: Prof. Huan-Xiang Zhou Education:  Institute of Theoretical and Computational Chemistry (ITCC), Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University Supervisor: Prof. Shuhua Li Dissertation title: Non-Covalent Interactions in Supra- and Bio-Molecules: from Structure to Reaction Mechanism  1999.9 ~ 2003.6 B. E. School of Biochemical Engineering, Nanjing University of Science and Technology Research Interests: Publications: (13) "Gating Mechanism of a P2X4 Receptor Developed from Normal Mode Analysis and Molecular Dynamics Simulations" Juan Du, Hao Dong, & Huan-Xiang Zhou* Proc. Natl. Acad. Sci. USA. 2012, 109, 4140. (12) "M2 Protein from Influenza A: from Multiple Structures to Biophysical and Functional Insights" Timothy A. Cross*, Hao Dong, Mukesh Sharma, David D. Busath, & Huan-Xiang Zhou Curr. Opin. Virol. 2012, 2, 128. (11) "Atomistic Mechanism for the Activation and Desensitization of an AMPA-Subtype Glutamate Receptor" Hao Dong, & Huan-Xiang Zhou* Nature Commun. 2011, 2, 354. (10) "Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer" Mukesh Sharma, Myunggi Yi, Hao Dong, Huajun Qin, Emily Peterson, David D. Busath, Huan-Xiang Zhou*, & Timothy A. Cross* Science 2010, 330, 509. (9) "Effects of Macromolecular Crowding on Protein Conformational Changes" Hao Dong, Sanbo Qin, & Huan-Xiang Zhou* PLoS Comput. Biol. 2010, 6, e1000833. Cover Story on C&E News, 11/29/2010 (8) "A Computational Study towards Understanding the Mechanism of Phosphodiester Cleavage by Two Mononuclear Zn(II) Complexes" Hao Dong Phys. Chem. Chem. Phys. 2010, 12, 10434. (7) "Understanding the Role of Intra- and Intermolecular Interactions in the Formation of Single- and Double-Helical Structures of Aromatic Oligoamides: A Computational Study" Hao Dong, Shugui Hua, & Shuhua Li* J. Phys. Chem. A 2009, 113, 1335. (6) "Unprecedented Immunosuppressive Polyketides from Daldinia eschscholzii, a Mantis-Associated Fungus" Yinglao Zhang, Huiming Ge, Wei Zhao, Hao Dong, Qiang Xu, Shuhua Li, Jing Li, Jie Zhang, Yongchun Song, & Renxiang Tan* Angew. Chem. Int. Ed. 2008, 47, 1. (5) "Temperature Controlled Reversible Change of the Coordination Modes of the Highly Symmetrical Multitopic Ligand To Construct Coordination Assemblies: Experimental and Theoretical Studies" Bo Zheng, Hao Dong, Junfeng Bai*, Yizhi Li, Shuhua Li*, & Manfred Scheer* J. Am. Chem. Soc. 2008, 130, 7778. (4) "Relative Energies of Proteins and Water Clusters Predicted with the Generalized Energy-Based Fragmentation Approach" Wei Li, Hao Dong, & Shuhua Li* in Progress in Theoretical Chemistry and Physics. Springer-Verlag, Berlin Heidelberg, 2008, 18, 289. (3) "A Smart Supramolecular Hydrogel: pH-Modulated Reversibly Viscoelastic Properties" Naien Shi, Hao Dong, Gui Yin, Zheng Xu*, & Shuhua Li* Adv. Funct. Mater. 2007, 17, 1837. (2) "Estimation on the Individual Hydrogen-Bond Strength in Molecules with Multiple Hydrogen Bonds" Hao Dong, Weijie Hua, & Shuhua Li* J. Phys. Chem. A 2007, 111, 2941. One of the Most-Accessed Articles, April-June, 2007 (1) "Theoretical Study toward Understanding the Catalytic Mechanism of Pyruvate Decarboxylase." Jianyi Wang, Hao Dong, & Shuhua Li* J. Phys. Chem. B 2005, 109, 18664. Awards: (5) 2009 Excellent Graduate Student Award, Key Laboratory of Mesoscopic Chemistry, Ministry of Education (4) 2008 Excellent Graduate Student Award, Nanjing University (3) 2007 Corning Award, US Corning Co. (2) 2007 Excellent Graduate Student Award, Key Laboratory of Mesoscopic Chemistry, Ministry of Education (1) 2003 Excellent Undergraduate Thesis Dissertation, Nanjing University of Science and Technology Conferences & Presentations: (8) 2011.3 Biophysical Society 55th Annual Meeting, Baltimore, Maryland (7) 2010.2 Biophysical Society 54th Annual Meeting, San Francisco, California (6) 2008.9 Theory and Applications of Computational Chemistry Conference, Shanghai (5) 2008.5 The 10th National Quantum Chemistry Conference, Nanjing (4) 2007.9 The 3rd Asian Pacific Conference on Theoretical & Computational Chemistry, Beijing (3) 2006.11 The 3rd Asian Biological Inorganic Chemistry Conference, Nanjing (2) 2004.9 EMBO-Course: "Methods for protein simulations and drug design", Shanghai (1) 2004.5 The 2nd Theoretical & Computational Chemistry Symposium, Nanjing Useful links: update: 05/05/2012 |