Fission yeast polarized cell growth

Investigate the dynamics of the regulatory network that controls the spatio-temporal organization of cytoskeleton in fission yeast cells.
The project is sponsored by the HFSP. More details on this here.

Collaborators: Federico Vaggi (CoSBi), Archana Bajpai (CoSBi), Rafael Carazo-Salas (Cambridge, UK), Masamitsu Sato (Tokyo)
Related papers:

Csikász-Nagy A, Gyorffy B, Alt W, Tyson JJ, Novák B.Spatial controls for growth zone formation during the fission yeast cell cycle.Yeast. 2008 25(1):59-69.PDF

Transcriptional regulation of cell cycle transitions
Collaborators: Alessandro Romanel (INRIA), Lars Juhl Jensen (Novo Nordisk Center for Protein Research)
Related papers:
Romanel A, Cardelli L, Jensen LJ, Csikász-Nagy A: Transcriptional regulation is a major controller of cell cycle transition dynamics. PLoS One 2012 7(1): e29716 PDF

 

Circadian clock – cell cycle coupling
Collaborators: Judit Zamborszky (CoSBi), Christian I. Hong (U. Cincinnati)
Related papers:
Hong CI, Zámborszky J, Csikász-Nagy A.Minimum criteria for DNA damage-induced phase advances in circadian rhythms. PLoS Comput Biol. 2009 5(5):e1000384.PDF
Zámborszky J, Hong CI, Csikász Nagy A.Computational analysis of mammalian cell division gated by a circadian clock: quantized cell cycles and cell size control. J Biol Rhythms. 2007 22(6):542-53.PDF

Sensitivity analysis of cell cycle models
Collaborators: Tamas Turanyi (ELTE)
Related papers:
Lovrics A, Csikász-Nagy A, Zsély IG, Zádor J, Turányi T, Novák B.Analysis of a budding yeast cell cycle model using the shapes of local sensitivity functions. Int J Chem Kinet. 2008 40(11):710-20.PDF
Lovrics A, Csikász-Nagy A, Zsély IG, Zádor J, Turányi T, Novák B. Time scale and dimension analysis of a budding yeast cell cycle model.BMC Bioinformatics. 2006 7:494.PDF

Robustness in fission yeast cell cycle regulation
Collaborators: Hisao Moriya (Yokohama), Bela Novak (Oxford)
Related papers:
Moriya H, Chino A, Kapuy O, Csikasz-Nagy A, Novak B: Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico, Molecular Systems Biology 2011, 7:556 PDF

Regulation of cell division in fission yeast cells
Collaborators: Archana Bajpai (CoSBi), Dannel McCollum (UMass), Kathy Gould (Vanderbilt), Mohan Balasubramanian (Temasek) 

Budding yeast cell size control
Collaborators: Alida Palmisiano (CoSBi), Marti Aldea (IBMB)