I. Develop magnetic resonance imaging methods to map neural plasticity in learning, memory, degeneration and regeneration Project 1: Manganese enhanced MRI of mossy fiber plasticity Project 2: Functional MRI of learning induced plasticity Project 3: MRI tracking of endogenous neural precursor in learning and degeneration II. Establish translational imaging biomarkers for diagnosis and prognosis of neurodegenerative diseases and tumor Project 1: Develop robust perfusion MRI method for the mouse brain Project 2: Longitudinal multi-contrast MRI of ApoE transgenic mice Project 3: Manganese enhanced MRI of DMT1 transgenic mice Project 4: Automated whole-brain analysis methods for rodent brain III. Pharmacological MRI for drug discovery Project 1: Pharmacological MRI of rodent brain Project 2: MRI of tumor angiogenesis  |