Industry Networking Session Betting on the Biology of Risk Taking
12 noon, Saturday, March 6 Luncheon from 12 to 1 pm at Sun
Asia Bistro, NUS Staff Staff Club (near Sport Complex/tennis courts
and Yusoff Ishak House) Map
Talk from 1.30 to 2.30 pm at adjoining function room,
Aquarius Room
Risk taking and its close cousin - gambling - often takes centre stage in societal debates, e.g., Singapore government's decision to license casinos as part of the integrated resorts. This talk will touch on how advances in neurobiology, including brain imaging and molecular genetics, and experimental economics have enabled a deeper understanding of people's attitude towards economic risk taking. Speaker's Profile Trade Talk
Gradient Optimization of a High Resolution Melt (HRM) Assay
for targeted cancer therapy screening
Dr Jimmie D. Lowery (Bio-Rad
Laboratories, USA)
2 - 3 pm, 2 March 2010 (Tuesday)
Dept of Paediatrics Conference/Library Room, Level 4
National University Hospital
High Resolution Melt (HRM) analysis can discriminate nucleotide
sequence differences among samples by comparing the differing DNA
melting behavior of different sample compositions. It is one of the
latest mutation screening method. HRM offers a cost-effective, rapid and
yet accurate alternative to probe-based genotyping assays or DNA
sequencing (White and Potts 2006). To develop a rapid screening tool to
identify KRAS mutations in clinical cancer samples, primers to detect
these mutations via HRM were developed (Krypuy M., et al. 2006). KRAS
mutations are found in a group of patients that do not respond to EGFR
targeted therapies for adenocarcinomas (Pao W. et al. 2005) and have an
associated poorer prognosis than those without the mutations (Keohavong
P. et al 1996). Scientific Seminar Cell cycle regulation of epigenetic gene silencing – implications and mechanisms
Dr Chen Ee Sin (Dept of Biochemistry, NUS)
28 Jan 2010 (Thursday), 6 – 7 pm
Department of Paediatrics Seminar Room 4D, Level 4, National University Hospital
Synopsis
Epigenetic mechanisms
impart functional states to regions of the eukaryotic genomes through
molecular mechanisms that are independent of DNA sequences. Once
established, these chromosomal characteristics can be
faithfully transmitted through multiple cell generations. This form of
“cell memory” is critical for the development and maintenance of
differentiated cell types and is implicated in a wide range of
processes including stem cell development, parental imprinting
and disease predisposition. How epigenetic states are established and
propagated across cell generation is still elusive, and hence we
employed a powerful model system, the fission yeast, to elucidate the
underlying molecular mechanisms. Our findings revealed
surprisingly that active transcription by RNA polymerase II is
paradoxically required for silencing of extended heterochromatic
domains, leading to a renewed understanding of how epigenetic silencing
is regulated during cell divisions. The biomedical implications
of these discoveries will be discussed.
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