Many current methods for the manufacture of chemical products rely primarily on non-renewable resources, consume large amounts of energy, and can often result in damage to human and ecological health. Our goal is to consider these challenges from a chemical perspective. What makes a chemical safe and sustainable? How do we improve our chemical methods to address issues of waste, energy consumption, and safety? And what roles do those from academia, industry, and public policy take in achieving these initiatives? We believe solving these problems represents a tremendous opportunity to develop new chemistries through both focused research and interdisciplinary collaboration.