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List of Publications

(most recent first)
  1. Radhakrishnan, A., Brown, M.S., McDonald, J.G., and Goldstein, J.L. 2008.  Cooperative control of SREBP-2 activation creates switch-like regulatory response to changes in ER cholesterol.  Cell Metabolism 8: 512-521.
  2. Infante, R.E., Wang, M.L., Radhakrishnan, A., Kwon, H.J., Brown, M.S., and Goldstein, J.L.  2008.  NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. PNAS 105: 15287-15292.
  3. McConnell, H. and A. Radhakrishnan. 2008.  Molecular motion at the critical point in lipid membranes.  Biophys. J. 95: L22-L24. 
  4. Infante, R.E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L.N., Wang, M.L., Grishin, N.V., Goldstein, J.L., and Brown, M.S. 2008.  Purified NPC1 protein: II.  Localization of sterol binding to a 240-amino acid soluble luminal loop. J. Biol. Chem. 283: 1064-1075.
  5. Infante, R.E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J., Brown, M.S., and Goldstein, J.L. 2008.  Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.  J. Biol. Chem. 283: 1052-1063.
  6. Radhakrishnan, A., Ikeda, Y., Kwon, H.J., Brown, M.S., and Goldstein, J.L. 2007. Sterol-regulated transport from endoplasmic reticulum to Golgi:  I.  Oxysterols block transport by binding to Insigs.  PNAS 104:  6511-6518.
  7. Radhakrishnan, A. and McConnell, H., 2007.  Composition fluctuations, chemical exchange and nuclear relaxation in membranes containing cholesterol.  J. Chem. Phys. 126: 185101.
  8. McConnell H. and Radhakrishnan, A. 2006.  Theory of the deuterium NMR of sterol-phospholipid membranes.  PNAS 103: 1184-1189.
  9. Feramisco, J.D., Radhakrishnan, A., Ikeda, Y., Reitz, J., Brown, M.S. and Goldstein, J.L., 2005.  Intramembrane aspartic acid in Scap governs cholesterol-mediated conformational change.  PNAS 102: 3242-3247.
  10. Radhakrishnan, A. and McConnell H.  2005.  Condensed complexes in vesicles containing cholesterol and phospholipids.  PNAS 102: 12662-12666.
  11. Radhakrishnan, A., Sun, L., Kwon, H.J., Brown, M.S., and Goldstein, J.L., 2004. Direct binding of cholesterol to the purified membrane region of SCAP:  Mechanism for a sterol-sensing domain.  Mol. Cell 15: 259-268.
  12. McConnell, H.M., and Radhakrishnan, A., 2003.  Condensed complexes of cholesterol and phospholipid.  BBA Reviews 1610: 159-173.
  13. Radhakrishnan, A. and McConnell, H.M., 2002.  Critical points in charged membranes containing cholesterol.  PNAS 99: 13391-13396.
  14. Okonogi, T.M., Radhakrishnan, A., and McConnell, H.M., 2002.  Two fatty acids can replace one phospholipid in condensed complexes with cholesterol.  Biochim. Biophys. Acta 1564: 1-4.
  15. Radhakrishnan, A. and McConnell, H.M., 2002.  Thermal dissociation of condensed complexes of cholesterol and phospholipid.  J. Phys. Chem. B 106: 4755-4762.
  16. Radhakrishnan, A., Li, X., Brown, R.E., and McConnell, H.M., 2001.  Stoichiometry of cholesterol-sphingomyelin condensed complexes in monolayers.  Biochim. Biophys. Acta 1511: 1-6.
  17. Radhakrishnan, A., Anderson, T.G., and McConnell, H.M., 2000.  Condensed complexes, rafts and the chemical activity of cholesterol.  PNAS 97: 12422-12427.
  18. Keller, S.L., Radhakrishnan, A., and McConnell, H.M., 2000.  Saturated phospholipids with high melting temperatures form complexes with cholesterol in monolayers.  J. Phys. Chem. B 104: 7522-7527.
  19. Radhakrishnan, A., and McConnell, H.M., 2000.  Chemical activity of cholesterol in membranes.  Biochemistry 39: 8119-8124.
  20. Radhakrishnan, A., and McConnell, H.M., 2000.  Electric field effect on cholesterol-phospholipid complexes.  PNAS 97: 1073-1078.
  21. Radhakrishnan, A., and McConnell, H.M., 1999.  Condensed complexes of cholesterol and phospholipids.  Biophys. J. 77: 1507-1517.
  22. Radhakrishnan, A., and McConnell, H.M., 1999.  Cholesterol-phospholipid complexes in membranes.  J. Am. Chem. Soc. 121: 486-487.
  23. Scherer, J.R., Kheterpal, I. Radhakrishnan, A., Ja, W.W., and Mathies, R.A., 1999. Ultra-high throughput rotary capillary array electrophoresis scanner for fluorescent DNA sequencing and analysis.  Electrophoresis 20: 1508-1517.
  24. Kheterpal, I., Scherer, J.R., Clark, S.M., Radhakrishnan, A., Ju, J., Ginther, C.L., Sensabaugh, G.F., and Mathies, R.A., 1996.  DNA sequencing using a four-color confocal fluorescence capillary array scanner.  Electrophoresis 17: 1852-1859.
  25. Kheterpal, I., Ju, J., Radhakrishnan, A., Brandt, G.S., Ginther, C.L., Clark, S.M., Scherer, J.R., Sensabaugh, G.F., and Mathies, R.A., 1996.  DNA sequencing using four-color capillary array electrophoresis and energy transfer primers.  Ultrasensitive Biochemical Diagnostics – Proceedings of the International Society for Optical Engineering-SPIE 2680: 204-213.