Understanding the genetic and environmental underpinnings of substance use behaviors
Arpana Agrawal, Ph.D.
I am an Assistant Professor of Psychiatry at Washington University School of Medicine in St. Louis. I
have a Bachelor's in Science (majors in Microbiology, Zoology and
Chemistry) as well as concurrent diplomas in Creative English,
Psychological Sciences and certificates in Entomology and Environmental
Sciences. In 2004, I received my doctorate in Human Genetics
(Quantitative) from Virginia Commonwealth University (VCU), Richmond,
VA. Under the mentorship of Dr. Kenneth Kendler, my dissertation
research focused on applying twin methodology to disentangling the
extent to which genetic and environmental factors influenced
predisposition to cannabis (marijuana) and other illicit/illegal (e.g.
cocaine, hallucinogens, non-prescription opioids, sedatives) use, abuse
and dependence. I continued my research into the genetic epidemiology
of cannabis-related behaviors during my postdoctoral training at Wash
U. During my postdoc (2004-2006), I worked with Drs. Pam Madden and
Andrew Heath on several genomic projects that aimed to identify regions
along the human genome, and the role of specific genes (e.g. nicotinic
receptors), that influence risk for nicotine dependence and alcoholism.
Currently, I am supported by the National Institute on Drug Abuse
(NIDA) to conduct twin research on why cannabis and
tobacco are commonly co-used across the world and to examine
the role of common genetic influences on these drugs. I also serve as
Principal Investigator on a project, from the Alcoholic Beverages
Medical Research Foundation (ABMRF), that aims to identify genetic
variants influencing risk for heavy alcohol consumption and to study
their interactions with stressful life events, especially those
occurring during childhood and early adolescence. Recently, I was funded to examine changes (and their correlates) in cannabis involvement in a large, nationally representative sample of US adults (NESARC) - these funds are from NIDA (supported by the American Recovery and Reinvestment Act). I also participate
as a co-investigator/collaborator on several grants on the genetics of
substance-related behaviors and led a phenotypic harmonization for alcohol-related measures on the GENEVA projects. |
