I moved to my current position in January 2010 after being eight moths with Prof. Lluis M. Mir at the UMR 8121 (Villejuif, France) of the Centre National de la Recherche Scientifique (CNRS) - Institut Gustave Roussy. That stay was preceded by a 4-year postdoctoral position at the University of California at Berkeley under the supervision of Prof. Boris Rubinsky. Prior to that, I did my PhD at the Biomedical Applications Group of the Centre Nacional de Microelectronica (Bellaterra, Spain).
My main areas of research are electroporation () and electrical bioimpedance (Ω). As an enginner, I have designed and built a number of devices.
[e-mail: antoni.ivorra@gmail.com // phone: +34 93 542 1578 // Carrer Roc Boronat 138 (room 51.008), Universitat Pompeu Fabra, E-08018 Barcelona, Spain.]
Publications in peer-reviewed
journals:
0. () A. Ivorra, B. Rubinsky, L.M. Mir, “Electric field
redistribution during tissue electroporation: its potential impact on treatment
planning”, Comptes Rendus Physique, 2010, Accepted.
1. () A. José, L. Sobrevals, A. Ivorra, C. Fillat, “Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models”, Cancer Letters, 2011, Available Online.
2. () A. Ivorra, “Remote electrical stimulation by means of implanted rectifiers”, PLoS ONE, 2011, 6(8): e23456.
3. () A. Ivorra, “Electrochemical prevention of needle-tract seeding”, Annals of Biomedical Engineering, 2011, 39(7): 2080-9.
4. () E. Maor, A. Ivorra, J.J. Mitchell, B. Rubinsky, “Vascular smooth muscle cells ablation with endovascular non thermal irreversible electroporation”, Journal of Vascular and Interventional Radiology, 2010, 21(11), 1708-1715.
5. (Ω) A. Guimera, A. Ivorra, G. Gabriel, R. Villa, “Non-invasive assessment of corneal endothelial permeability by means of electrical impedance measurements”, Medical Engineering & Physics, 2010, 32(10), 1107-1115 (DOI: 10.1016/j.medengphy.2010.07.016) © 2010 IPEM. Published by Elsevier Ltd.
6. () A. Ivorra, J. Villemejane, L.M. Mir, “Electrical Modeling of the Influence of Medium Conductivity on Electroporation”, Physical Chemistry Chemical Physics, 2010, 12(34): 10055-64.
7. (Ω) S. Laufer, A. Ivorra, V.E. Reuter, B. Rubinsky, S.B. Solomon, “Electrical impedance characterization of normal and cancerous human hepatic tissue”, Physiological Measurement, 2010, 31(7): 995-1009. © 2010 Institute of Physics and IOP Publishing Limited.
8. (,Ω) A. Ivorra, B.
Al-Sakere, B. Rubinsky, L.M. Mir, “In vivo electrical conductivity measurements
during and after tumor electroporation: conductivity changes reflect the
treatment outcome”, Physics in Medicine and Biology, 2009, 54(19): 5949-5963. © 2009 Institute of Physics and IOP Publishing Limited.
9. (Ω) A. Ivorra, M. Shini, B. Rubinsky, “Linear superposition electrical impedance tomography imaging with multiple electrical/biopsy probes”, IEEE Transactions on Biomedical Engineering, 2009, 56(5):1465-1472. © 2009 Institute of Electrical and Electronics Engineers, Inc.
10. (,Ω) Y. Granot, A. Ivorra, E. Maor, B. Rubinsky, “In vivo imaging of
irreversible electroporation by means of electrical impedance tomography”,
Physics in Medicine and Biology, 2009, 54(16): 4927-4943.© 2009 Institute of Physics and IOP Publishing Limited.
11. () E. Maor, A. Ivorra, B. Rubinsky, “Non thermal irreversible
electroporation: novel technology for vascular smooth muscle cells ablation”,
PLoS ONE, 2009, 4(3):e4757.
12. () A. Ivorra, B. Al-Sakere, B. Rubinsky, L.M. Mir, “Use of conductive gels
for electric field homogenization increases the antitumor efficacy of
electroporation therapies”, Physics in Medicine and Biology, 2008, 53(22):
6605-6618.© 2008 Institute of Physics and IOP Publishing Limited.
13. () A. Ivorra, C.
Daniels, B. Rubinsky, “Minimally obtrusive wearable device for continuous interactive
cognitive and neurological assessment”, Physiological Measurement, 2008 , 29(5):543-554.© 2008 Institute of Physics and IOP Publishing Limited.
14. (Ω) Y. Granot, A. Ivorra, B. Rubinsky, “A new concept for medical imaging centered on the cellular phone”, PLoS ONE, 2008, 3(4):e2075.
15. (Ω) J. F. Edd, A. Ivorra, L. Horowitz, B. Rubinsky, “Imaging cryosurgery with EIT: tracking the ice front and post-thaw tissue viability”, Physiological Measurement, 2008, 29(8):899-912. © 2008 Institute of Physics and IOP Publishing Limited.
16. () E. Maor, A. Ivorra,
J. Leor, B. Rubinsky, “Irreversible Electroporation Attenuates Neointimal
Formation after Angioplasty”, IEEE Transactions on Biomedical Engineering,
2008, 55(9): 2268-2274.© 2008 Institute of Electrical and Electronics Engineers, Inc.
17. () A. Ivorra, B.
Rubinsky, “Electric field modulation in tissue electroporation with electrolytic
and non-electrolytic additives”, Bioelectrochemistry, 2007, 70(2):551-560. © 2007 Elsevier B.V.
18. (,Ω) A. Ivorra, B.
Rubinsky, “In vivo electrical impedance measurements during and after electroporation
of rat liver”, Bioelectrochemistry, 2007, 70(2):287-295.© 2007 Elsevier B.V.
19. () E. Maor, A. Ivorra,
J. Leor, B. Rubinsky,” The Effect of Irreversible Electroporation on Blood
Vessels”, Technology in Cancer Research and Treatment, 2007, 4(6), 307-312. © 2007 Adenine Press.
20. (Ω) Y. Granot, A. Ivorra, B. Rubinsky,” Frequency-division multiplexing for electrical impedance tomography in biomedical applications”, Int J Biomed Imaging., 2007, 2007: 54798.
21. (Ω) D. Parramon, I. Erill, A. Guimerà, A. Ivorra, A. Muñoz, A. Sola, C. Fondevila, J.C. García-Valdecasas, R. Villa. “In vivo detection of liver steatosis in rats based on impedance spectroscopy”, Physiological Measurement, 2007, 28(8):813-828. © 2007 Institute of Physics and IOP Publishing Limited.
22. (Ω) R. Gómez, A. Ivorra, R. Villa, P. Godignon, J. Millán, I. Erill, A. Sola, G. Hotter, L. Palacios, “A SiC microdevice for the minimally invasive monitoring of ischemia in living tissues”, Biomedical Microdevices, 2006, 8(1), 43-49. © 2006 Springer Science + Business Media, Inc.
23. (Ω) A. Ivorra, M. Genescà, A. Sola, L. Palacios, R. Villa, G. Hotter, J Aguiló, “Bioimpedance dispersion width as a parameter to monitor living tissues”, Physiological Measurement, 2005, 26 (2), S165-173. © 2005 Institute of Physics and IOP Publishing Limited.
24. (Ω) M. Genescà, A. Ivorra, A. Sola, L. Palacios, J.M. Goujon, T. Hauet, R. Villa, J. Aguiló, and G. Hotter, Electrical bioimpedance measurement during hypothermic rat kidney preservation for assessing ischemic injury”, Biosensors & Biolectronics, 2005, 20(9), 1866- 1871. © 2004 Elsevier B.V.
25. I. Erill, S. Campoy, J. Rus, L. Fonseca, A. Ivorra, Z. Navarro, J.A. Plaza, J. Aguiló, and J. Barbé, “Development of a CMOS-compatible PCR chip: comparison of design and system strategies”, Journal of Micromechanics and Microengineering, 2004, 14, 1558-1568.
26. (Ω) A. Ivorra, R. Gómez, N. Noguera, R. Villa, A. Sola, L. Palacios, G. Hotter, and J. Aguiló, “Minimally invasive silicon probe for electrical impedance measurements in small animals”, Biosensors & Biolectronics, 2003, 19(4), 391-399. © 2003 Elsevier B.V.
27. (Ω) A. Sola, L. Palacios, J. López-Martí, A. Ivorra, N. Noguera, R. Gómez, R. Villa, J. Aguiló, and G. Hotter, “Multiparametric monitoring of ischemia-reperfusion in rat kidney: effect of ischemic preconditioning”, Transplantation, 2003, 75(6), 744-774. © 2003 Lippincott Williams & Wilkins.
28. N. Zine, J. Bausells, A. Ivorra, J. Aguiló, M. Zabala, F. Teixidor, C. Masalles, C. Viñas, A. Errachid, “Hydrogen-selective microelectrodes based on silicon needles”, Sensors and Actuators B: Chemical, 2003, 91:1-3, 76-82
29. A. Errachid, A. Ivorra, J. Aguiló, R. Villa, N. Zine, J. Bausells, “New technology for multi-sensor silicon needles for biomedical applications”, Sensors and Actuators B: Chemical, 2001, vol. 78:1-3, 279-284. © 2001 Elsevier B.V.
Book chapters:
1. (,Ω) A.
Ivorra, “Tissue Electroporation as a Bioelectric Phenomenon: Basic Concepts" pp. 23-61 in "Irreversible Electroporation" Ed. B. Rubinsky, 2010, Springer-Verlag Berlin Heidelberg, ISBN: 978-3-642-05419-9. The original publication is available at www.springerlink.com
2. () A.
Ivorra, B. Rubinsky “Historical Review of Irreversible Electroporation in Medicine" pp. 1-21 in "Irreversible Electroporation" Ed. B. Rubinsky, 2010, Springer-Verlag Berlin Heidelberg, ISBN: 978-3-642-05419-9. The original publication is available at www.springerlink.com
3. () A.
Silve, J. Villemejane, V. Joubert, A. Ivorra, L.M. Mir “Nanosecond pulsed electric field delivery to biological samples: difficulties and potential solutions" chapter 18 in "Advanced Electroporation Techniques in Biology and Medicine" Ed. A.G. Pakhomov, D. Miklavcic, M.S. Markiv, 2010, CRC Press, ISBN: 978-1-439-81906-7. The original publication is available at www.crcpress.com
1. (,Ω) A. Silve, A. Ivorra, L.M. Mir, "Detection of permeabilisation obtained by micropulses and nanopulses by means of bioimpedance of biological tissues", Proceedings of the 5th European Conference on Antennas and Propagation (EUCAP), 3164-3167, April 11-15, 2011, Rome, Italy. © 2011 Institute of Electrical and Electronics Engineers, Inc.
2. () A. Ivorra, "Irreversible Electroporation for Tissue Ablation", Invited Lecturer, 5th Course ("Medical Applications of Electromagnetic Fields: Research and Therapy") of the School of Bioelectromagnetism Alessadro Chiabreara, November 21-28, 2010, Ettore Majorana Foudation, Erice, Sicily, Italy.
3. (,Ω) A. Ivorra, "Introduction to tissue Irreversible Electroporation and effects of electroporation on tissue passive electrical properties", Invited Speaker, Bioelectrochemistry Gordon Research Conference, July 11-16, 2010, University of New England, Biddeford, Maine, USA.
4. () A. Ivorra, L.M. Mir, B. Rubinsky, "Electric
Field Redistribution due to Conductivity Changes during Tissue Electroporation:
Experiments with a Simple Vegetal Model ", Oral presentation, World Congress 2009 on Medical Physics and
Biomedical Engineering, publication: IFMBE Proceedings 25(13): 59-62, September
7-12, 2009, Munich, Germany.
5. () E. Maor, A.
Ivorra, J. Mitchell, B. Rubinsky, "Endovascular non-thermal irreversible electroporation, a novel electric
ablation method, efficiently ablates vascular smooth muscle cells in rabbit
iliac arteries evaluated at 7 and 35 days", European Society of Cardiology
Congress 2009, August 29 - September 2, Barcelona, Spain.
6. () A. Ivorra, "Irreversible Electroporation", Oral Presentation, International Bioelectrics Symposium, June 25-26, 2009, University of Missouri, Columbia, Missouri, USA.
7. () A. Ivorra, B. Al-Sakere, B. Rubinsky, L. M. Mir, "Use of conductive gels for
electric field modulation in tissue electroporation therapies", Poster,
Bioelectrochemistry Gordon Research Conference, July 20-25, 2008, Biddeford,
Maine, USA.
8. () E. Maor, A. Ivorra, B. Rubinsky, "Intravascular irreversible electroporation: Theoretical and experimental
feasibility study", Oral presentation, 30th Annual International Conference
of the IEEE Engineering in medicine and biology society, publication: IEEE
Engineering in medicine and biology society conference proceedings (2008), v.1,
pp. 2051-2054, 2008, Vancouver, British Columbia, Canada. © 2008 Institute of Electrical and Electronics Engineers, Inc.
9. (,Ω) A. Ivorra, L. Miller, B. Rubinsky, "Electrical impedance measurements during
electroporation of rat liver and muscle", Oral presentation, XIII
International Conference on Electrical Bioimpedance (ICEBI), 29-8-2007.
publication: Proceedings of XIII International Conference on Electrical Bioimpedance
(ICEBI), IFMBE Proceedings 17(5):130-133, 2007, Graz, Austria.
10. () A. Ivorra, B. Rubinsky, "Optimum Conductivity of Gels for Electric Field
Homogenization in Tissue Electroporation Therapies", Oral presentation, IV
Latin American Congress on Biomedical Engineering (CLAIB), September 24th-28th,
2007, publication: Proceedings of the IV Latin American Congress on Biomedical
Engineering (CLAIB). 2007, IFMBE Proceedings 18(5): 619-622, Margarita Island,
Venezuela.© 2007 Springer-Verlag Berlin HeidelbergElsevier B.V.
11. (,Ω) A. Ivorra, B. Rubinsky "Impedance analyzer for in vivo electroporation
studies", Poster, 28th Annual International Conference of the IEEE
Engineering in Medicine and Biology Society, August 30 – September 3, 2006, publication: Proceedings of the 28th Annual International Conference of the
IEEE Engineering in Medicine and Biology Society, 5056-5060. 2006, New York, USA. © 2009 Institute of Electrical and Electronics Engineers, Inc.
12. (Ω) A. Ivorra, M. Genescà, G. Hotter, J. Aguiló, "Bio-impedance dispersion widht as a parameter to monitor living tissues", Oral presentation, XII International Conference on Electrical BioImpedance (ICEBI) , June 20-24, 2004, publication: Proceedings of the XII International Conference on Electrical BioImpedance , 87-89, 2004, Gdansk, Poland.
13. (Ω) M. Dalmases, A. Ivorra, R. Villa, L. Blanch, A. Villagrá, J. López, E. Piacentini, J. Desola "Electrical impedance monitoring in risk detection of pulmonary barotrauma in divers, preliminary results", Oral presentation, XII International Conference on Electrical BioImpedance (ICEBI) , June 20-24, 2004, publication: Proceedings of the XII International Conference on Electrical BioImpedance , 103-106, 2004, Gdansk, Poland.
14. (Ω) A. Ivorra,
R. Gómez, J. Aguiló, "A SPICE netlist generator to simulate living tissue electrical impedance", Poster presentation, XII
International Conference on Electrical BioImpedance (ICEBI) , June
20-24, 2004, publication: Proceedings of the XII International Conference on Electrical BioImpedance , 317-320, 2004, Gdansk, Poland.
15. (Ω) N. Noguera,
A. Ivorra, R. Gómez, R. Villa, J. Aguiló, "Platinization of micro-electrodes for living tissue impedance measurements", Poster presentation, XII
International Conference on Electrical BioImpedance (ICEBI) , June
20-24, 2004, publication: Proceedings of the XII International Conference on Electrical BioImpedance , 359-362, 2004, Gdansk, Poland.
16. (Ω) M. Genescà, A. Ivorra, A. Sola, L. Palacios, R. Villa, G. Hotter, "Electrical bio-impedance monitoring of rat kidneys during cold preservation by employing a silicon probe", Poster presentation, XII
International Conference on Electrical BioImpedance (ICEBI) , June
20-24, 2004, publication: Proceedings of the XII International Conference on Electrical BioImpedance , 127-130, 2004, Gdansk, Poland.
17. (Ω) R. Villa, L. Sánchez, A. Guimerà, A. Ivorra, R. Gómez, J. Aguiló, "A new system for the bioimpedance monitoring of organs for transplantation", Poster presentation, XII International Conference on Electrical BioImpedance (ICEBI) , June 20-24, 2004, publication: Proceedings of the XII International Conference on Electrical BioImpedance , 119-122, 2004, Gdansk, Poland.
PhD thesis dissertation: (Ω) "Contributions to the measurement of electrical impedance of living tissue for ischemia injury monitoring", Dept. Electronic Engineering, Universitat Politècnica de Catalunya (Barcelona, Spain), 2005.
Patents:
1. B. Rubinsky, E. Maor, A. Ivorra, J. Mitchell, W. Hamilton, "Ballonn catheter for reducing restenosis via irreversible electroporation", PCT/US2009/03866, priority date: March 27, 2008.
2. B. Rubinsky, E. Maor, A. Ivorra, "Method of modulating restenosis and catheter used for same", 61/040,110, USA, priority date: March 27, 2008.
3. B. Rubinsky, Y. Granot, A. Ivorra, "Cellular Phone Enabled Medical Imaging System", 60/936,063, USA, PCT/US2008/007605, priority date: June 18, 2007.
4. A. Ivorra, B. Rubinsky, "Neuro-cognitive stimulation and analysis", 60/852746, USA, PCT/US2007/022304, priority date: October 19, 2006.
5. A. Ivorra, B. Rubinsky, "Liquids and gels with predetermined conductivity used in electroporation of tissue", 60829587, USA, PCT/US2007/022110, priority date: October 16, 2006.
6. A. Ivorra, J. L. Abadia, J. Ureña, "Dispositivo electrónico de medición para aparatos gimnástico", U 200301237, Utility model, Spain, priority date: May 7, 2003.
7. A. Ivorra, "Electronic physical exercise system", P200200674, Spain, PCT/ES 03/00101, priority date: March 11, 2002.
8. A. Ivorra, I. Erill, A. Errachid, J. Aguiló, "Electromagnetic system for manipulating fluids", ES2158808, Spain, WO0128682, priority date: September 1, 2001.
9. Villa R., Guimerà A., Parramon D., Erill I., Ivorra A, Aguiló J, "Apparatus for diagnosis and monitoring of hepatic steatosis based on electrical impedance measurement", P200602518, Spain, PCT/IB2007/003753, priority date: October 3,2006.