Welcome to the laboratory of Brian M. Baker in the Department of Chemistry and Biochemistry at the University of Notre Dame.
Our laboratory studies the principles of molecular recognition in the
immune system using a variety of structural, biophysical, and molecular
techniques. We aim to understand the mechanisms by which the immune
system recognizes, distinguishes between, and cross-reacts with
antigens. We are also studying the design and optimization of
immunologically-based therapeutics for cancer and infectious disease.
Our
work in the immune system builds on fundamental studies relating
interaction thermodynamics and kinetics to macromolecular structures
and dynamics. As such, we are firmly grounded in protein biophysics and
structural biology. At the same time, we are guided by work in
molecular and cellular immunology, performed both in our lab and by
collaborators throughout the world.
Our work is funded by the National Institutes of Health (NIGMS), the National Science Foundation, the American Cancer Society, the Walther Cancer Institute, and the Indiana CTSI.
Laboratory rooms and phone numbers: Main lab: 453 Stepan Group room: 450 Stepan -2601 Instrument room: 501 Stepan -5320 BMB office: 451 Stepan -9810 Fax: -6652 Mailing address: Baker Lab |
