Cells are [still] black boxes

Most of the details of how their fundamental components – proteins – interact, co-localize and traffick together to manifest complex functional responses remain hidden from view. Our mission is to generate the first complete cellular proteome maps with unprecedented detail to reveal disease mechanisms and find new drug targets.

Until now

Prisma is building the new era of high definition spatial proteomics

Our Technology

Unveiling the Cellular Proteome: A New Era of Biomedical Research

Imagine a world where we can map every protein within a cell, revealing its location and function in stunning detail. This is the future Prisma is building with in situ proteomics, a revolutionary approach that analyzes proteins directly in their native environment.

This video dives into the core concepts behind Prisma's groundbreaking technology. Our innovative platform leverages the power of our OMNI Probe, a novel reagent that binds directly to the n-terminal amino acid of proteins and generates unique fluorescent signatures based on the amino acid side chain and post-translational modifications. Combined with our cutting-edge, light-based sequencing technique, Prisma's platform enables proteome-scale analysis of proteins, whether they reside on a surface or within the intricate world of a cell.