Scientist

Institute of Genomics and Integrative Biology

Research Interest: Functional Genomics

Contact: s.sivasubbu@igib.res.in

                sridhar@igib.in

 Education

Ph.D - Manonmaniam Sundaranar University, India (2001)

M.Sc -St. Xavier's College, Palayamkottai, India (1996)

Research

Genome sequencing projects in a variety of organisms have led to the unprecedented accumulation of sequence information. While biological information for many of these genes has been documented, functional annotation of the tens of thousands of protein-encoding, non-coding RNA including micro-RNA genes of unknown in vivo function still remains a major challenge to biology. Zebrafish provides a near ideal vertebrate genetic system to identify and annotate the biological role(s) of these novel genes because of their optical transparency, rapid embryonic development, short generation time and rapidly advancing genomic manipulation tools.  This vertebrate model organism provides opportunities for conducting studies in areas such as functional genomics, organogenesis and drug discovery.

The mission of the laboratory is to exploit the advantages of zebrafish to dissect molecular mechanisms of gene function, regulation and genome organization in vertebrates.

Another area keen interest in the laboratory has been application of High-throughput Next Generation Sequencing technologies for whole genome re-sequencing initiatives and genome scale activities to understanding the transcriptome and variome.

Zebrafish Genome Resources

FishMap is a unified and centralized resource for storage, retrieval, and display of genomic information of zebrafish. (in collaboration with Dr. Vinod Scaria, IGIB)

Laboratory Address

IGIB Extension  Center at Naraina,

A93-94 Naraina Inds Area, Phase 1,

Naraina, New Delhi -110 028, India.

Ph- +91-11-25895615, 45073677/88/99

Fax no: +91-11-2766 7471

News and Events

Researchers Find Their Nemo - Leading Edge Analysis Article in the Journal Cell reviews the whole genome zebrafish re-sequencing initiatives at IGIB. For more information see http://www.cell.com/abstract/S0092-8674%2809%2901431-7 (Cell, Volume 139, Issue 5, 843-846, 25 November 2009).

Human Genome Sequencing - CSIR scientist at IGIB declared success in decoding the human genome in India. For more information see reports.
(in collaboration with Dr. Vinod Scaria and other staff & students of IGIB)

Zebrafish wildtype strain genome sequencing - IGIB completes the whole genome sequencing of a Wildtype strain of zebrafish (Danio rerio).  For more information see http://genome.igib.res.in
(in collaboration with Dr. Vinod Scaria, IGIB & Dr. Stephen Ekker, Mayo Clinic, USA) See press coverage of the genome release.

Selected Publications

Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, Moulder GL, Thomas MJ, Ekker SC.
Nicotine response genetics in the zebrafish.
Proc Natl Acad Sci U S A. 2009 Oct 26

Kumar N, Patowary A, Sivasubbu S, Petersen M, Maiti S.
Silencing c-MYC expression by targeting quadruplex in P1 promoter using locked nucleic acid trap.
Biochemistry. 2008 Dec 16;47(50):13179-88.

Meli R, Prasad A, Patowary A, Lalwani MK, Maini MK, Sharma M,
Singh AR, Kumar G, Jadhav V, Scaria V*, Sivasubbu S*.
FishMap: A community resource for Zebrafish genomics.
Zebrafish June 1, 2008, 5(2): 125-130 Cover Article

Indian Genome Variation Consortium*
Genetic Landscape of the People of India: a Canvas for Disease Gene Exploration
J Genetics 2008 (*as co-author of the consortia) Cover Article

Sivasubbu S, Balciunas D, Amsterdam A, Ekker SC.
Insertional mutagenesis strategies in zebrafish.
Genome Biol. 2007;8 Suppl 1:S9.

For more publications click here.